BR0310061A - Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições - Google Patents
Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composiçõesInfo
- Publication number
- BR0310061A BR0310061A BR0310061-8A BR0310061A BR0310061A BR 0310061 A BR0310061 A BR 0310061A BR 0310061 A BR0310061 A BR 0310061A BR 0310061 A BR0310061 A BR 0310061A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitor
- methods
- conditions
- respiratory diseases
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000023504 respiratory system disease Diseases 0.000 title abstract 3
- 229940124639 Selective inhibitor Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 101100396994 Drosophila melanogaster Inos gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 101000998969 Homo sapiens Inositol-3-phosphate synthase 1 Proteins 0.000 abstract 1
- 229940119568 Inducible nitric oxide synthase inhibitor Drugs 0.000 abstract 1
- 102100036881 Inositol-3-phosphate synthase 1 Human genes 0.000 abstract 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"METODOS PARA O TRATAMENTO DE DOENçAS E CONDIçõES RESPIRATóRIAS COM UM INIBIDOR SELETIVO DA INOS E UM INIBIDOR DA PDE E SUAS COMPOSIçõES". São descritos métodos terapêuticos para a prevenção e o tratamento de doenças ou condições respiratórias, os métodos incluindo a administração a um indivíduo necessitado destes uma quantidade eficaz para a doença ou condição respiratória de um inibidor seletivo da óxido nítrico sintase indutível.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38105602P | 2002-05-16 | 2002-05-16 | |
| PCT/US2003/015464 WO2003097050A2 (en) | 2002-05-16 | 2003-05-16 | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0310061A true BR0310061A (pt) | 2005-03-01 |
Family
ID=29550061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0310061-8A BR0310061A (pt) | 2002-05-16 | 2003-05-16 | Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040087653A1 (pt) |
| EP (1) | EP1505972A2 (pt) |
| JP (1) | JP2005532321A (pt) |
| AU (1) | AU2003232148A1 (pt) |
| BR (1) | BR0310061A (pt) |
| CA (1) | CA2484654A1 (pt) |
| MX (1) | MXPA04011335A (pt) |
| WO (1) | WO2003097050A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| US20070049599A1 (en) * | 2003-10-31 | 2007-03-01 | Altana Pharma Ag | Use of bh4 for the treatment of respiratory diseases |
| EP1755595A1 (en) * | 2004-05-10 | 2007-02-28 | Altana Pharma AG | Use of roflumilast for the prophylaxis or treatment of emphysema |
| NZ561746A (en) * | 2005-04-19 | 2011-09-30 | Nycomed Gmbh | Roflumilast for the treatment of pulmonary hypertension |
| WO2007100525A2 (en) * | 2006-02-27 | 2007-09-07 | Fil-Am Tech., Inc. | Methods for the treatment of viral diseases |
| US20090186854A1 (en) * | 2006-03-23 | 2009-07-23 | Meditor Pharmaceuticals Ltd. | S-alkylisothiouronium derivatives for the treatment of inflammatory diseases |
| WO2007134077A2 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2009039069A1 (en) | 2007-09-20 | 2009-03-26 | University Of Rochester | Method and compositions for treatment or prevention of inflammatory conditions |
| JP5372943B2 (ja) | 2007-10-11 | 2013-12-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規sEH阻害剤およびそれらの使用 |
| WO2009112874A1 (en) * | 2008-03-10 | 2009-09-17 | Eurodrug Laboratories B.V. | Modified release composition comprising doxofylline |
| JP2010018562A (ja) * | 2008-07-11 | 2010-01-28 | Kitasato Institute | トリパノソーマ原虫類の感染予防・治療剤 |
| WO2016022825A1 (en) * | 2014-08-07 | 2016-02-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2016022836A1 (en) * | 2014-08-07 | 2016-02-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN111060623A (zh) * | 2019-12-26 | 2020-04-24 | 北京鑫开元医药科技有限公司 | 一种多索茶碱杂质的检测方法 |
| CN115448833B (zh) * | 2022-08-25 | 2024-07-05 | 湖北泰盛化工有限公司 | 一种多官能团脂肪族伯醇衍生物的羟基直接氯代方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| EP0957087B1 (en) * | 1994-06-15 | 2002-12-04 | The Wellcome Foundation Limited | Intermediates useful in the preparation of enzyme inhibitors |
| US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| AU6823098A (en) * | 1997-02-28 | 1998-09-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists |
| WO1999046240A2 (en) * | 1998-03-11 | 1999-09-16 | G.D. Searle & Co. | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
| GB9810299D0 (en) * | 1998-05-15 | 1998-07-15 | Glaxo Group Ltd | Use of nitric oxide synthase inhibitors |
| GB9811599D0 (en) * | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| WO2000026195A1 (en) * | 1998-10-30 | 2000-05-11 | G.D. Searle & Co. | Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors |
| AU2847200A (en) * | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
| WO2001005748A1 (en) * | 1999-07-15 | 2001-01-25 | Monsanto Company | Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors |
| DK1265859T3 (da) * | 2000-03-24 | 2006-05-01 | Pharmacia Corp | Amidinoforbindelser der er nyttige som nitrogenoxidsyntaseinhibitorer |
| US6545170B2 (en) * | 2000-04-13 | 2003-04-08 | Pharmacia Corporation | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
| US6787668B2 (en) * | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
| AR032318A1 (es) * | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
| AR034120A1 (es) * | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
| US6953774B2 (en) * | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| AR035585A1 (es) * | 2000-09-15 | 2004-06-16 | Pharmacia Corp | Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos |
| AR031129A1 (es) * | 2000-09-15 | 2003-09-10 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
| MY131964A (en) * | 2000-09-15 | 2007-09-28 | Pharmacia Corp | 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors |
-
2003
- 2003-05-16 EP EP03753056A patent/EP1505972A2/en not_active Withdrawn
- 2003-05-16 US US10/439,679 patent/US20040087653A1/en not_active Abandoned
- 2003-05-16 MX MXPA04011335A patent/MXPA04011335A/es unknown
- 2003-05-16 JP JP2004505049A patent/JP2005532321A/ja not_active Withdrawn
- 2003-05-16 CA CA002484654A patent/CA2484654A1/en not_active Abandoned
- 2003-05-16 AU AU2003232148A patent/AU2003232148A1/en not_active Abandoned
- 2003-05-16 WO PCT/US2003/015464 patent/WO2003097050A2/en not_active Ceased
- 2003-05-16 BR BR0310061-8A patent/BR0310061A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003097050A3 (en) | 2004-06-17 |
| MXPA04011335A (es) | 2005-07-01 |
| CA2484654A1 (en) | 2003-11-27 |
| AU2003232148A1 (en) | 2003-12-02 |
| JP2005532321A (ja) | 2005-10-27 |
| EP1505972A2 (en) | 2005-02-16 |
| US20040087653A1 (en) | 2004-05-06 |
| AU2003232148A8 (en) | 2003-12-02 |
| WO2003097050A2 (en) | 2003-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A,5A,6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |