BR0311556A - Derivados de n-((3-oxo-2,3-diidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina pectoris - Google Patents

Derivados de n-((3-oxo-2,3-diidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina pectoris

Info

Publication number: BR0311556A
Authority: BR; Brazil
Prior art keywords: treatment; infarction; angina pectoris; nhe; oxo
Prior art date: 2002-06-03

Application number

BR0311556A

Other languages

English (en)

Portuguese (pt)

Inventor

Heinz Werner Kleemann

Armin Hofmeister

Jean-Christophe Carry

Serge Mignani

Antony Bigot

Baptiste Ronan

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-03

Filing date

2003-05-20

Publication date

2005-04-12

2003-05-20 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2005-04-12 Publication of BR0311556A publication Critical patent/BR0311556A/pt

Links

238000011282 treatment Methods 0.000 title abstract 4
206010002383 Angina Pectoris Diseases 0.000 title abstract 3
206010061216 Infarction Diseases 0.000 title abstract 3
230000007574 infarction Effects 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
MGRUNSIBUNAFKA-UHFFFAOYSA-N n-(diaminomethylidene)-2-(3-oxo-1,2-dihydroisoindol-1-yl)acetamide Chemical class C1=CC=C2C(CC(=O)NC(=N)N)NC(=O)C2=C1 MGRUNSIBUNAFKA-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
208000028867 ischemia Diseases 0.000 abstract 2
XTBAPWCYTNCZTO-UHFFFAOYSA-N isoindol-1-one Chemical class C1=CC=C2C(=O)N=CC2=C1 XTBAPWCYTNCZTO-UHFFFAOYSA-N 0.000 abstract 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 abstract 1
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000003293 cardioprotective effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000006378 damage Effects 0.000 abstract 1
108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 abstract 1
229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000035778 pathophysiological process Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

BR0311556A 2002-06-03 2003-05-20 Derivados de n-((3-oxo-2,3-diidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina pectoris BR0311556A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0206783A FR2840302B1 (fr)	2002-06-03	2002-06-03	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
PCT/EP2003/005279 WO2003101450A1 (fr)	2002-06-03	2003-05-20	Derives de guanidine n- ((3-oxo-2, 3-dihydro-1h-isoindole-1-yle) acetyle) comme inhibiteurs de nhe-1 pour traiter l'infarctus et l'angine pectorale

Publications (1)

Publication Number	Publication Date
BR0311556A true BR0311556A (pt)	2005-04-12

Family

ID=29558914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR0311556A BR0311556A (pt)	2002-06-03	2003-05-20	Derivados de n-((3-oxo-2,3-diidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina pectoris

Country Status (41)

Country	Link
US (2)	US7078428B2 (fr)
EP (1)	EP1528923B1 (fr)
JP (1)	JP4634793B2 (fr)
KR (1)	KR101149771B1 (fr)
CN (1)	CN1290833C (fr)
AR (1)	AR039927A1 (fr)
AT (1)	ATE324889T1 (fr)
AU (1)	AU2003240677B2 (fr)
BR (1)	BR0311556A (fr)
CA (1)	CA2488373C (fr)
CY (1)	CY1105115T1 (fr)
DE (1)	DE60305042T2 (fr)
DK (1)	DK1528923T3 (fr)
EC (1)	ECSP045472A (fr)
EG (1)	EG24784A (fr)
ES (1)	ES2261939T3 (fr)
FR (1)	FR2840302B1 (fr)
HN (1)	HN2003000162A (fr)
HR (1)	HRP20041151B1 (fr)
IL (1)	IL165520A (fr)
JO (1)	JO2357B1 (fr)
MA (1)	MA27308A1 (fr)
ME (1)	MEP27508A (fr)
MX (1)	MXPA04011931A (fr)
MY (1)	MY142502A (fr)
NO (1)	NO329224B1 (fr)
NZ (1)	NZ536953A (fr)
OA (1)	OA12864A (fr)
PA (1)	PA8574701A1 (fr)
PE (1)	PE20040531A1 (fr)
PL (1)	PL372188A1 (fr)
PT (1)	PT1528923E (fr)
RS (1)	RS51636B (fr)
RU (1)	RU2318809C2 (fr)
SI (1)	SI1528923T1 (fr)
TN (1)	TNSN04237A1 (fr)
TW (1)	TWI286545B (fr)
UA (1)	UA81118C2 (fr)
UY (1)	UY27835A1 (fr)
WO (1)	WO2003101450A1 (fr)
ZA (1)	ZA200409094B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7531569B2 (en)	2003-12-02	2009-05-12	Sanofi-Aventis Deutschland Gmbh	Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
DE10356717A1 (de) *	2003-12-02	2005-07-07	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
KR100518184B1 (ko) *	2003-12-27	2005-10-04	한국화학연구원	퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
TW200613272A (en)	2004-08-13	2006-05-01	Astrazeneca Ab	Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en)	2005-08-12	2010-10-05	Astrazeneca Ab	Metabotropic glutamate-receptor-potentiating isoindolones
WO2007047646A2 (fr) *	2005-10-14	2007-04-26	Janssen Pharmaceutica, N.V.	Dihydroisoindolones substituées pouvant être employées dans le traitement de troubles des kinases
TW200812962A (en) *	2006-07-12	2008-03-16	Astrazeneca Ab	New compounds I/418
TWI417100B (zh)	2007-06-07	2013-12-01	Astrazeneca Ab	二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
US7790760B2 (en)	2008-06-06	2010-09-07	Astrazeneca Ab	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
GB0811643D0 (en)	2008-06-25	2008-07-30	Cancer Rec Tech Ltd	New therapeutic agents
WO2012003147A1 (fr) *	2010-07-01	2012-01-05	Merck Sharp & Dohme Corp.	Modulateurs allostériques positifs du récepteur m1 de l'isoindolone
AR088320A1 (es)	2011-10-14	2014-05-28	Incyte Corp	Derivados de isoindolinona y pirrolopiridinona como inhibidores de akt
CN103193794B (zh) *	2013-04-12	2016-04-06	中国药科大学	一种异吲哚酮并异噁唑类稠环化合物及其合成方法
GB201517217D0 (en)	2015-09-29	2015-11-11	Astex Therapeutics Ltd And Cancer Res Technology Ltd	Pharmaceutical compounds
GB201517216D0 (en)	2015-09-29	2015-11-11	Cancer Res Technology Ltd And Astex Therapeutics Ltd	Pharmaceutical compounds
CN106316922B (zh) *	2016-08-17	2019-02-01	华东师范大学	一种含c-3全取代氧化吲哚衍生物及其合成方法和应用
US10344002B2 (en)	2016-09-26	2019-07-09	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders
GB201704966D0 (en)	2017-03-28	2017-05-10	Astex Therapeutics Ltd	Pharmaceutical compounds
GB201704965D0 (en)	2017-03-28	2017-05-10	Astex Therapeutics Ltd	Pharmaceutical compounds
CN110664803B (zh) *	2019-09-19	2023-08-29	中山大学	异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用

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FR2708605A1 (fr) *	1993-07-30	1995-02-10	Sanofi Sa	Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
ATE157351T1 (de) *	1993-02-20	1997-09-15	Hoechst Ag	Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
FR2735166B1 (fr) *	1995-06-08	1997-08-29	Aerospatiale	Procede de fabrication d'un panneau ou analogue a proprietes structurale et acoustique et panneau ainsi obtenu
DE19737224A1 (de) *	1997-08-27	1999-03-18	Hoechst Marion Roussel De Gmbh	Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
DE19737463A1 (de) *	1997-08-28	1999-03-04	Hoechst Marion Roussel De Gmbh	Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden
DE19738604A1 (de) *	1997-09-04	1999-03-11	Hoechst Marion Roussel De Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe
YU46200A (sh) *	1998-02-27	2003-02-28	Pfizer Products Inc.	N-(supstituisani peto-članog di-ili triaza dinezasićenog prstena)karbonil/guanidin derivati za tretiranje ishemije
DE19859727A1 (de) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
US6534651B2 (en) *	2000-04-06	2003-03-18	Inotek Pharmaceuticals Corp.	7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
BR0110268A (pt) *	2000-04-28	2003-12-30	Pfizer Prod Inc	Inibidores de permutadores sódio-hidrogênio do tipo 1(nhe-1)
DE10046993A1 (de) *	2000-09-22	2002-04-11	Aventis Pharma Gmbh	Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
EP1767525A1 (fr) *	2001-04-09	2007-03-28	Novartis Vaccines and Diagnostics, Inc.	Composés guanidino comme agonistes du récepteur 4 de la mélanocortine (MC4-R)

2002
- 2002-06-03 FR FR0206783A patent/FR2840302B1/fr not_active Expired - Fee Related
2003
- 2003-05-07 JO JO200351A patent/JO2357B1/en active
- 2003-05-20 PT PT03730076T patent/PT1528923E/pt unknown
- 2003-05-20 WO PCT/EP2003/005279 patent/WO2003101450A1/fr not_active Ceased
- 2003-05-20 NZ NZ536953A patent/NZ536953A/en not_active IP Right Cessation
- 2003-05-20 AU AU2003240677A patent/AU2003240677B2/en not_active Ceased
- 2003-05-20 CN CNB038128500A patent/CN1290833C/zh not_active Expired - Fee Related
- 2003-05-20 JP JP2004508808A patent/JP4634793B2/ja not_active Expired - Fee Related
- 2003-05-20 EP EP20030730076 patent/EP1528923B1/fr not_active Expired - Lifetime
- 2003-05-20 DK DK03730076T patent/DK1528923T3/da active
- 2003-05-20 MX MXPA04011931A patent/MXPA04011931A/es active IP Right Grant
- 2003-05-20 RU RU2004138789A patent/RU2318809C2/ru not_active IP Right Cessation
- 2003-05-20 ES ES03730076T patent/ES2261939T3/es not_active Expired - Lifetime
- 2003-05-20 DE DE2003605042 patent/DE60305042T2/de not_active Expired - Lifetime
- 2003-05-20 PL PL37218803A patent/PL372188A1/xx unknown
- 2003-05-20 BR BR0311556A patent/BR0311556A/pt not_active IP Right Cessation
- 2003-05-20 RS YUP104804 patent/RS51636B/sr unknown
- 2003-05-20 ME MEP27508 patent/MEP27508A/xx unknown
- 2003-05-20 KR KR1020047019619A patent/KR101149771B1/ko not_active Expired - Fee Related
- 2003-05-20 SI SI200330302T patent/SI1528923T1/sl unknown
- 2003-05-20 AT AT03730076T patent/ATE324889T1/de active
- 2003-05-20 UA UA20041211001A patent/UA81118C2/uk unknown
- 2003-05-20 OA OA1200400323A patent/OA12864A/en unknown
- 2003-05-20 CA CA 2488373 patent/CA2488373C/fr not_active Expired - Fee Related
- 2003-05-20 HR HRP20041151AA patent/HRP20041151B1/hr not_active IP Right Cessation
- 2003-05-27 US US10/445,618 patent/US7078428B2/en not_active Expired - Lifetime
- 2003-05-29 PE PE2003000523A patent/PE20040531A1/es not_active Application Discontinuation
- 2003-05-30 TW TW92114642A patent/TWI286545B/zh not_active IP Right Cessation
- 2003-05-30 HN HN2003000162A patent/HN2003000162A/es unknown
- 2003-05-30 AR ARP030101923 patent/AR039927A1/es active IP Right Grant
- 2003-06-01 EG EG2003060521A patent/EG24784A/xx active
- 2003-06-02 PA PA8574701A patent/PA8574701A1/es unknown
- 2003-06-02 MY MYPI20032036 patent/MY142502A/en unknown
- 2003-06-03 UY UY27835A patent/UY27835A1/es unknown
2004
- 2004-11-10 ZA ZA2004/09094A patent/ZA200409094B/en unknown
- 2004-11-16 MA MA27951A patent/MA27308A1/fr unknown
- 2004-11-30 TN TNP2004000237A patent/TNSN04237A1/en unknown
- 2004-12-02 IL IL165520A patent/IL165520A/en not_active IP Right Cessation
- 2004-12-02 EC ECSP045472 patent/ECSP045472A/es unknown
- 2004-12-27 NO NO20045660A patent/NO329224B1/no not_active IP Right Cessation
2006
- 2006-03-01 US US11/365,319 patent/US7589117B2/en not_active Expired - Fee Related
- 2006-07-28 CY CY20061101057T patent/CY1105115T1/el unknown

Also Published As

Publication number	Publication date
EG24784A (en)	2010-09-01
EP1528923A1 (fr)	2005-05-11
ES2261939T3 (es)	2006-11-16
CA2488373C (fr)	2012-07-17
HRP20041151A2 (en)	2005-06-30
US20040048916A1 (en)	2004-03-11
CN1658869A (zh)	2005-08-24
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BR0013041A (pt)	2002-07-16	Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método
CA2387134A1 (fr)	2001-05-10	Nouveaux cyclopropanes utilises comme antagonistes de cgrp, medicaments contenant lesdits composes et procedes permettant de les preparer
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MEP28908A (en)	2010-10-10	Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing same
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