BR0313101A - Novos lipopeptìdeos imunogênicos que compreendem epitopos de linfócitos t-helper e linfócitos t citotóxicos (ctl), e métodos para sua produção e uso - Google Patents

Novos lipopeptìdeos imunogênicos que compreendem epitopos de linfócitos t-helper e linfócitos t citotóxicos (ctl), e métodos para sua produção e uso

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Publication number
BR0313101A
BR0313101A BR0313101-7A BR0313101A BR0313101A BR 0313101 A BR0313101 A BR 0313101A BR 0313101 A BR0313101 A BR 0313101A BR 0313101 A BR0313101 A BR 0313101A
Authority
BR
Brazil
Prior art keywords
ctl
production
methods
lipopeptides
cytotoxic
Prior art date
Application number
BR0313101-7A
Other languages
English (en)
Inventor
David Jackson
Weiguang Zeng
Original Assignee
Queensland Inst Med Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queensland Inst Med Res filed Critical Queensland Inst Med Res
Publication of BR0313101A publication Critical patent/BR0313101A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
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    • A61K2039/55511—Organic adjuvants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
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    • A61K2039/6031—Proteins
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    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"NOVOS LIPOPEPTìDEOS IMUNOGêNICOS QUE COMPREENDEM EPITOPOS DE LINFóCITOS T-HELPER E LINFóCITOS T CITOTóXICOS (CTL), E MéTODOS PARA SUA PRODUçãO E USO". A presente invenção fornece moléculas sintéticas de lipopeptídeo imunogênica que compreendem epitopos de Thelper e de CTL co-lineares, e métodos para sua produção e uso na geração de respostas imunes primárias e secundárias, e para a vacinação de animais contra epitopos de CTL particulares. Mais particularmente, a presente invenção fornece lipopeptídeos altamente solúveis onde a porção de lipídeo é ligada ao grupo de cadeia lateral terminal de uma lisina interna ou análogo de lisina, preferivelmente ao grupo de cadeia lateral terminal de um resíduo de diaminoácido interno. Preferivelmente a lisina interna ou análogo de lisina está posicionada entre o epitopo T-helper e o epitopo de CTL.
BR0313101-7A 2002-08-12 2003-08-12 Novos lipopeptìdeos imunogênicos que compreendem epitopos de linfócitos t-helper e linfócitos t citotóxicos (ctl), e métodos para sua produção e uso BR0313101A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40332802P 2002-08-12 2002-08-12
PCT/AU2003/001019 WO2004014957A1 (en) 2002-08-12 2003-08-12 Novel immunogenic lipopeptides comprising t-helper and cytotoxic t lymphocyte (ctl) epitopes

Publications (1)

Publication Number Publication Date
BR0313101A true BR0313101A (pt) 2005-06-28

Family

ID=31715974

Family Applications (1)

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BR0313101-7A BR0313101A (pt) 2002-08-12 2003-08-12 Novos lipopeptìdeos imunogênicos que compreendem epitopos de linfócitos t-helper e linfócitos t citotóxicos (ctl), e métodos para sua produção e uso

Country Status (10)

Country Link
US (2) US7833532B2 (pt)
EP (2) EP2314630A1 (pt)
JP (2) JP4619121B2 (pt)
KR (1) KR101151368B1 (pt)
CN (2) CN101113178A (pt)
AU (1) AU2003249778B2 (pt)
BR (1) BR0313101A (pt)
CA (1) CA2494193A1 (pt)
ES (1) ES2535451T3 (pt)
WO (1) WO2004014957A1 (pt)

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CN101113178A (zh) 2008-01-30
JP2006513979A (ja) 2006-04-27
CA2494193A1 (en) 2004-02-19
EP1546206A4 (en) 2007-10-10
EP1546206B1 (en) 2014-12-17
JP5265512B2 (ja) 2013-08-14
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US20110280899A1 (en) 2011-11-17
US7833532B2 (en) 2010-11-16
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CN1688605B (zh) 2011-01-12
KR101151368B1 (ko) 2012-06-08
WO2004014957A1 (en) 2004-02-19
US20070160631A1 (en) 2007-07-12
JP4619121B2 (ja) 2011-01-26
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