BR0314860A - Derivados de pirazol - Google Patents
Derivados de pirazolInfo
- Publication number
- BR0314860A BR0314860A BR0314860-2A BR0314860A BR0314860A BR 0314860 A BR0314860 A BR 0314860A BR 0314860 A BR0314860 A BR 0314860A BR 0314860 A BR0314860 A BR 0314860A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- preparation
- reverse transcriptase
- present
- pyrazole derivatives
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 2
- 102100034343 Integrase Human genes 0.000 abstract 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
"DERIVADOS DE PIRAZOL". A presente invenção refere-se a derivados de pirazol de fórmula ou seus sais, solvatos ou derivados farmaceuticamente aceitáveis, em que R^ 1^ até R^ 4^, n W, X e Y estão definidos na descrição, e com processos para a sua preparação, utilização de intermediários nas suas preparações, composições contendo-os e a utilização desses derivados. Os compostos da presente invenção ligam-se à enzima transcriptase reversa e são moduladores, especialmente seus inibidores. Desta forma, os compostos da presente invenção são úteis no tratamento de uma variedade de distúrbios incluindo aqueles em que está implicada a inibição da transcriptase reversa. Os distúrbios de interesse incluem aqueles causados pelo Vírus da Imunodificiência Humana (HIV) e retrovírus geneticamente relacionados, tais como Síndrome de Imunodeficiência Adquirida (AIDS).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223232.0A GB0223232D0 (en) | 2002-10-07 | 2002-10-07 | Chemical compounds |
| PCT/IB2003/004205 WO2004031178A1 (en) | 2002-10-07 | 2003-09-24 | Pyrazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0314860A true BR0314860A (pt) | 2005-08-02 |
Family
ID=9945428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0314860-2A BR0314860A (pt) | 2002-10-07 | 2003-09-24 | Derivados de pirazol |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1551828B1 (pt) |
| JP (1) | JP2006512299A (pt) |
| AT (1) | ATE384714T1 (pt) |
| AU (1) | AU2003263498A1 (pt) |
| BR (1) | BR0314860A (pt) |
| CA (1) | CA2501502A1 (pt) |
| DE (1) | DE60318874T2 (pt) |
| ES (1) | ES2298616T3 (pt) |
| GB (1) | GB0223232D0 (pt) |
| MX (1) | MXPA05002735A (pt) |
| WO (1) | WO2004031178A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| US7868008B2 (en) | 2005-08-12 | 2011-01-11 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| CN101309905A (zh) * | 2005-08-12 | 2008-11-19 | 阿斯利康(瑞典)有限公司 | 取代的异吲哚酮及其作为代谢型谷氨酸受体增效剂的用途 |
| CA2658984C (en) | 2006-08-16 | 2014-12-02 | Joshua Kennedy-Smith | Non-nucleoside reverse transcriptase inhibitors |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| EP2170836A1 (en) | 2007-06-22 | 2010-04-07 | F. Hoffmann-Roche AG | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
| RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| DE102008015033A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| SA109300358B1 (ar) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) * | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
| RS51166B (sr) * | 2001-04-10 | 2010-10-31 | Pfizer Inc. | Derivati pirazola za tretiranje hiv |
-
2002
- 2002-10-07 GB GBGB0223232.0A patent/GB0223232D0/en not_active Ceased
-
2003
- 2003-09-24 ES ES03799022T patent/ES2298616T3/es not_active Expired - Lifetime
- 2003-09-24 AT AT03799022T patent/ATE384714T1/de not_active IP Right Cessation
- 2003-09-24 EP EP03799022A patent/EP1551828B1/en not_active Expired - Lifetime
- 2003-09-24 AU AU2003263498A patent/AU2003263498A1/en not_active Abandoned
- 2003-09-24 WO PCT/IB2003/004205 patent/WO2004031178A1/en not_active Ceased
- 2003-09-24 DE DE60318874T patent/DE60318874T2/de not_active Expired - Fee Related
- 2003-09-24 CA CA002501502A patent/CA2501502A1/en not_active Abandoned
- 2003-09-24 MX MXPA05002735A patent/MXPA05002735A/es unknown
- 2003-09-24 JP JP2004541068A patent/JP2006512299A/ja not_active Withdrawn
- 2003-09-24 BR BR0314860-2A patent/BR0314860A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60318874T2 (de) | 2009-01-22 |
| ATE384714T1 (de) | 2008-02-15 |
| AU2003263498A1 (en) | 2004-04-23 |
| CA2501502A1 (en) | 2004-04-15 |
| EP1551828A1 (en) | 2005-07-13 |
| DE60318874D1 (en) | 2008-03-13 |
| WO2004031178A1 (en) | 2004-04-15 |
| EP1551828B1 (en) | 2008-01-23 |
| JP2006512299A (ja) | 2006-04-13 |
| ES2298616T3 (es) | 2008-05-16 |
| MXPA05002735A (es) | 2005-05-23 |
| GB0223232D0 (en) | 2002-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 403/06, C07D 471/04, A61K 31/415, A61P 25/00 Ipc: C07D 403/06 (2011.01), C07D 471/04 (2011.01), A61K |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |