ATE374775T1 - Inhibitoren des hiv-integrase-enzyms - Google Patents

Inhibitoren des hiv-integrase-enzyms

Info

Publication number
ATE374775T1
ATE374775T1 AT05718436T AT05718436T ATE374775T1 AT E374775 T1 ATE374775 T1 AT E374775T1 AT 05718436 T AT05718436 T AT 05718436T AT 05718436 T AT05718436 T AT 05718436T AT E374775 T1 ATE374775 T1 AT E374775T1
Authority
AT
Austria
Prior art keywords
enzyme inhibitors
integrase enzyme
hiv integrase
hiv
inhibitors
Prior art date
Application number
AT05718436T
Other languages
English (en)
Inventor
Klaus Dress
Qiyue Hu
Ted Johnson
Michael Plewe
Steven Tanis
Huichun Zhu
Junhu Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE374775T1 publication Critical patent/ATE374775T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05718436T 2004-04-26 2005-04-13 Inhibitoren des hiv-integrase-enzyms ATE374775T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56572804P 2004-04-26 2004-04-26
US64331605P 2005-01-11 2005-01-11
US65759405P 2005-02-28 2005-02-28
US66043005P 2005-03-09 2005-03-09

Publications (1)

Publication Number Publication Date
ATE374775T1 true ATE374775T1 (de) 2007-10-15

Family

ID=34964479

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05718436T ATE374775T1 (de) 2004-04-26 2005-04-13 Inhibitoren des hiv-integrase-enzyms

Country Status (10)

Country Link
US (2) US7692014B2 (de)
EP (1) EP1751157B1 (de)
JP (1) JP2007534738A (de)
AT (1) ATE374775T1 (de)
BR (1) BRPI0510306A (de)
CA (1) CA2563761C (de)
DE (1) DE602005002746T2 (de)
ES (1) ES2292123T3 (de)
MX (1) MXPA06012342A (de)
WO (1) WO2005103051A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
GB8720125D0 (en) 1987-08-26 1987-09-30 Roussel Lab Ltd Chemical compounds
HU212435B (en) * 1990-06-07 1996-06-28 Sandoz Ag Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients.
US5616609A (en) 1991-08-08 1997-04-01 Ikekawa; Tetsuro Carcinostatic compound and production thereof
ATE175873T1 (de) * 1992-03-20 1999-02-15 Wellcome Found Weitere indolderivate mit antiviraler wirkung
GB2271566A (en) 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
EP0713877A1 (de) 1993-07-19 1996-05-29 LUO, Xuande Qinghaosuderivate zur bekämpfung von aids
GB2306476A (en) 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
AU4917397A (en) 1996-10-31 1998-05-22 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
GB2327674A (en) 1997-07-29 1999-02-03 Merck & Co Inc HIV integrase inhibitors
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
EP1086101B1 (de) 1998-06-12 2002-12-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Betacarbolinverbindungen
AU777036B2 (en) * 1999-05-12 2004-09-30 Antonio Garofalo Thiazepine inhibitors of HIV-1 integrase
US6245806B1 (en) * 1999-08-03 2001-06-12 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
EP1209158A1 (de) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
JP2004517802A (ja) * 2000-06-16 2004-06-17 ブリストルーマイヤーズ スクイブ カンパニー Ｈｉｖインテグラーゼ阻害剤
WO2002002516A2 (en) 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
JP4176477B2 (ja) 2001-03-01 2008-11-05 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環誘導体
CN1659143A (zh) 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
JP2003171381A (ja) 2001-09-25 2003-06-20 Takeda Chem Ind Ltd エントリー阻害剤
JP2003119137A (ja) 2001-10-10 2003-04-23 Japan Tobacco Inc Ｈｉｖ阻害剤
EP1438310B1 (de) 2001-10-19 2006-12-20 TransTech Pharma Inc. Beta-carbolin-derivate als ptp-inhibitoren
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
AU2002349675A1 (en) 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
CA2469592C (en) 2001-12-12 2005-08-23 Bristol-Myers Squibb Company Hiv integrase inhibitors
EP1467970B1 (de) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
WO2003077857A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003082881A2 (en) * 2002-03-28 2003-10-09 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
EP1499391A2 (de) 2002-04-10 2005-01-26 Merck & Co., Inc. Pharmazeutische zusammensetzungen mit einem hiv-integrase-hemmer und einem nichtionischen tensid
AU2002335027A1 (en) 2002-10-15 2004-05-04 Chiron Corporation Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) * 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
BRPI0510319A (pt) * 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
JP2008512442A (ja) 2004-09-07 2008-04-24 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
JP2009510157A (ja) 2005-10-03 2009-03-12 ファイザー・プロダクツ・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase

Also Published As

Publication number Publication date
EP1751157B1 (de) 2007-10-03
MXPA06012342A (es) 2007-01-17
DE602005002746D1 (de) 2007-11-15
JP2007534738A (ja) 2007-11-29
WO2005103051A1 (en) 2005-11-03
BRPI0510306A (pt) 2007-09-04
US20100137283A1 (en) 2010-06-03
ES2292123T3 (es) 2008-03-01
EP1751157A1 (de) 2007-02-14
US20050277661A1 (en) 2005-12-15
CA2563761A1 (en) 2005-11-03
US7692014B2 (en) 2010-04-06
CA2563761C (en) 2009-12-29
DE602005002746T2 (de) 2008-02-07

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