BR0315537A - Pró-drogas ativadas por peptìdeo desformilase - Google Patents

Pró-drogas ativadas por peptìdeo desformilase

Info

Publication number
BR0315537A
BR0315537A BR0315537-4A BR0315537A BR0315537A BR 0315537 A BR0315537 A BR 0315537A BR 0315537 A BR0315537 A BR 0315537A BR 0315537 A BR0315537 A BR 0315537A
Authority
BR
Brazil
Prior art keywords
peptide deformylase
activated prodrugs
toxin
linker
activated
Prior art date
Application number
BR0315537-4A
Other languages
English (en)
Inventor
Carlo Ballatore
Venkata Ramana Doppalapudi
Maria V Sergeeva
Original Assignee
Celmed Oncology Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celmed Oncology Usa Inc filed Critical Celmed Oncology Usa Inc
Publication of BR0315537A publication Critical patent/BR0315537A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4084—Esters with hydroxyaryl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

"PRó-DROGAS ATIVADAS POR PEPTìDEO DESFORMILASE". Esta invenção fornece compostos e métodos para empregá-los para inibir o crescimento de microorganismo que expresse Peptídeo Desformilase, os compostos tendo a fórmula geral (I). Ligador-B~ 5-~Toxina~ 1~ Ligador-B~ 6-~Toxina~ 2~.
BR0315537-4A 2002-11-14 2003-11-14 Pró-drogas ativadas por peptìdeo desformilase BR0315537A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42677102P 2002-11-14 2002-11-14
PCT/US2003/036124 WO2004043400A2 (en) 2002-11-14 2003-11-14 Peptide deformylase activated prodrugs

Publications (1)

Publication Number Publication Date
BR0315537A true BR0315537A (pt) 2005-09-27

Family

ID=32313139

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315537-4A BR0315537A (pt) 2002-11-14 2003-11-14 Pró-drogas ativadas por peptìdeo desformilase

Country Status (8)

Country Link
US (2) US7001922B2 (pt)
EP (1) EP1585751A4 (pt)
JP (1) JP2006514009A (pt)
AU (1) AU2003290779A1 (pt)
BR (1) BR0315537A (pt)
CA (1) CA2505914A1 (pt)
TW (1) TW200418508A (pt)
WO (1) WO2004043400A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1399467A4 (en) 2001-05-09 2004-09-15 Newbiotics Inc PRODRUGS ACTIVATED BY PEPTIDDEFORMYLASE
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP2186811A1 (en) 2002-08-23 2010-05-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
EP1845087A1 (en) 2006-04-14 2007-10-17 Mutabilis SA Hydroxyphenyl derivatives and biological applications thereof
DK2473480T3 (en) 2009-09-01 2016-09-05 Fab Pharma Sas Novel antibacterial hydroxyphenylforbindelse
PL3176165T3 (pl) * 2014-07-30 2019-03-29 Teijin Pharma Limited Kryształ pochodnej azolobenzenowej jako inhibitor oksydazy ksantynowej

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053638A (en) 1970-05-06 1977-10-11 William Wrigley Jr. Company Anticaries confectioneries and oral health products
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
IT1081511B (it) * 1976-07-13 1985-05-21 Hoffmann La Roche Derivati di peptidi e loro preparazione
US4083974A (en) 1977-03-07 1978-04-11 The Upjohn Company Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
HU181013B (en) 1980-01-25 1983-05-30 Gyogyszerkutato Intezet Process for preparing new enkephalin analogues
US4427660A (en) * 1982-03-03 1984-01-24 Research Corporation Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
US4415590A (en) * 1982-04-26 1983-11-15 Betamed Pharmaceuticals, Inc. Herpes treatment
US5350681A (en) * 1986-08-18 1994-09-27 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
US5274113A (en) * 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
AU2115695A (en) 1994-03-10 1995-09-25 G.D. Searle & Co. L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
ZA962455B (en) 1995-03-31 1996-10-02 B Eugene Guthery Fast acting and persistent topical antiseptic
US5842441A (en) 1996-08-26 1998-12-01 Pharmalett Denmark A/S Medicated and individualized treatment shampoo for dermatological disturbances of companion animals
WO1998013059A1 (en) 1996-09-27 1998-04-02 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
WO1999008110A1 (en) 1997-08-08 1999-02-18 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
US6448058B1 (en) 1997-09-12 2002-09-10 Versicor, Inc. Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
US6159706A (en) 1997-12-23 2000-12-12 Newbiotics, Inc. Application of enzyme prodrugs as anti-infective agents
IL137164A0 (en) 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
US6613879B1 (en) 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
HK1053126A1 (zh) 1999-07-22 2003-10-10 新生物生物公司 酶催化的治疗活化
EP1399467A4 (en) 2001-05-09 2004-09-15 Newbiotics Inc PRODRUGS ACTIVATED BY PEPTIDDEFORMYLASE
AU2003225047A1 (en) 2002-04-18 2003-11-03 Celmed Oncology (Usa), Inc. Peptide deformylase activated prodrugs

Also Published As

Publication number Publication date
US7001922B2 (en) 2006-02-21
AU2003290779A1 (en) 2004-06-03
US20060063743A1 (en) 2006-03-23
CA2505914A1 (en) 2004-05-27
EP1585751A4 (en) 2008-08-13
WO2004043400A3 (en) 2004-09-30
TW200418508A (en) 2004-10-01
WO2004043400A2 (en) 2004-05-27
EP1585751A2 (en) 2005-10-19
JP2006514009A (ja) 2006-04-27
US20040236096A1 (en) 2004-11-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]