BR0318319A - métodos de preparação e formulações/composições sustentadas pelo uso de dimeticona como veìculo - Google Patents
métodos de preparação e formulações/composições sustentadas pelo uso de dimeticona como veìculoInfo
- Publication number
- BR0318319A BR0318319A BRPI0318319-0A BR0318319A BR0318319A BR 0318319 A BR0318319 A BR 0318319A BR 0318319 A BR0318319 A BR 0318319A BR 0318319 A BR0318319 A BR 0318319A
- Authority
- BR
- Brazil
- Prior art keywords
- dimethicone
- formulation
- sustained
- formulations
- vehicle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 238000009472 formulation Methods 0.000 title abstract 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 title abstract 5
- 229940008099 dimethicone Drugs 0.000 title abstract 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 title abstract 4
- 239000004205 dimethyl polysiloxane Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 230000002459 sustained effect Effects 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 244000045947 parasite Species 0.000 abstract 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 abstract 1
- 239000005660 Abamectin Substances 0.000 abstract 1
- 229950008167 abamectin Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 229960001275 dimeticone Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 abstract 1
- 229940124641 pain reliever Drugs 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODOS DE PREPARAçãO E FORMULAçõES/COMPOSIçõES SUSTENTADAS PELO USO DE DIMETICONA COMO VEìCULO". A presente invenção diz respeito à preparação de formulação sustentada pelo uso de dimeticona como veículo. A referida formulação consiste em ingrediente ativo (por exemplo, medicamentos contra parasitas, inseticidas, NSAIDs, antibióticos, agentes semelhantes a hormónio sexual ou vitaminas oleosas solúveis) 0,5~40% (P/V) , dimeticona 100% (V/V). Também podem ser adicionados um estabilizador adequado, um antioxidante, analgésicos locais e material para a liberação sustentada. A formulação que compreende agentes de abamectinas contra parasites, que é preparada com dimeticona como meio, pode fornecer ação duradoura de até 50-120 dias por injeção subcutânea em uma única administração. O período de duração pode ser modificado pelo ajuste da dosagem de administração. A formulação de acordo com a presente invenção é biocompatível, estável e injetável.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN03138019 | 2003-05-25 | ||
| CN 03148883 CN1565445A (zh) | 2003-06-16 | 2003-06-16 | 含n－苯基吡唑类药物的兽用长效注射剂 |
| CNA031535690A CN1533764A (zh) | 2003-04-02 | 2003-08-18 | 含非甾体抗炎药物的缓释注射剂 |
| CNB031568769A CN1256948C (zh) | 2003-05-25 | 2003-09-11 | 含阿维菌素类抗寄生虫药物的长效注射剂 |
| PCT/CN2003/000849 WO2004103343A1 (fr) | 2003-05-25 | 2003-10-08 | Formulation a liberation prolongee a base de dimethicone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0318319A true BR0318319A (pt) | 2006-07-18 |
Family
ID=33479733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318319-0A BR0318319A (pt) | 2003-05-25 | 2003-10-08 | métodos de preparação e formulações/composições sustentadas pelo uso de dimeticona como veìculo |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7648711B2 (pt) |
| EP (1) | EP1634584A1 (pt) |
| AU (1) | AU2003275509A1 (pt) |
| BR (1) | BR0318319A (pt) |
| MX (1) | MXPA05012791A (pt) |
| WO (1) | WO2004103343A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| ES2532906T5 (es) | 2002-10-25 | 2022-03-23 | Foamix Pharmaceuticals Ltd | Espuma cosmética y farmacéutica |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| BRPI0705822A2 (pt) * | 2007-10-25 | 2009-06-23 | Schering Plough Saude Animal Ltda | formulação injetável com ação prolongada e uso de um agente semi-sintético derivado do grupo das avermectinas, em combinação com um polìmero biodegradável |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| US9820977B2 (en) * | 2008-10-03 | 2017-11-21 | Bayer Healthcare Llc | Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
| US20130053353A1 (en) * | 2010-05-04 | 2013-02-28 | Foamix Ltd. | Compositions, gels and foams with rheology modulators and uses |
| WO2012144943A1 (en) * | 2011-04-18 | 2012-10-26 | Lipidor Ab | Liquid carrier for oral delivery of a pharmacologically active agent |
| FR3000400B1 (fr) * | 2012-12-27 | 2019-06-21 | Virbac | Suspension huileuse de metronidazole |
| CN103142458B (zh) | 2013-01-22 | 2015-09-09 | 莱普德制药有限公司 | 无成瘾性镇痛缓释递药系统的组方与制备方法 |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
| CN108261410B (zh) * | 2016-12-30 | 2020-10-27 | 武汉回盛生物科技股份有限公司 | 一种酒石酸泰万菌素包合肠溶制剂及制备方法 |
| BR102017010598A2 (pt) | 2017-05-19 | 2018-12-04 | Flavio Alves Da Rocha | composições veterinárias de liberação retardada para controle de ovos e larvas de helmintos nas fezes dos ruminantes, uso das composições, uso de antelmínticos com essa finalidade |
| CN110420184A (zh) * | 2019-09-16 | 2019-11-08 | 上海欣峰制药有限公司 | 一种注射用头孢米诺钠制剂及其制备和使用方法 |
| CN110507615A (zh) * | 2019-09-16 | 2019-11-29 | 上海欣峰制药有限公司 | 一种注射用头孢地嗪钠制剂及其制备和使用方法 |
| CN110478317A (zh) * | 2019-09-16 | 2019-11-22 | 上海欣峰制药有限公司 | 一种注射用头孢噻肟钠制剂及其制备方法和悬浮液 |
| CN116059137A (zh) * | 2022-12-08 | 2023-05-05 | 上海雅兰生物科技有限公司 | 一种胶原舒缓美肌面膜配方及其制备方法 |
| CN117530920B (zh) * | 2023-12-08 | 2025-09-23 | 艾美科健（中国）生物医药有限公司 | 一种头孢噻呋复方注射液及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385738A (en) * | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| DK0535734T3 (da) * | 1991-09-30 | 1999-08-09 | Merck & Co Inc | Langtidsvirkende injicerbare formuleringer indeholdende hydrogeneret castorolie |
| DE4409357C2 (de) * | 1994-03-18 | 1996-10-17 | Upmeyer Hans Juergen | Verwendung von Dimeticon zur Eradikation von Heliobacter pylori |
| JP2001342138A (ja) * | 2000-05-31 | 2001-12-11 | Yoshiaki Nagaura | ウィルスを不活化する方法 |
| WO2004093886A1 (en) * | 2003-04-24 | 2004-11-04 | Galderma S.A. | Topical formulation of ivermectin for the treatment of dermatological conditions |
-
2003
- 2003-10-08 US US10/558,151 patent/US7648711B2/en not_active Expired - Fee Related
- 2003-10-08 BR BRPI0318319-0A patent/BR0318319A/pt not_active IP Right Cessation
- 2003-10-08 EP EP03757632A patent/EP1634584A1/en not_active Withdrawn
- 2003-10-08 AU AU2003275509A patent/AU2003275509A1/en not_active Abandoned
- 2003-10-08 MX MXPA05012791A patent/MXPA05012791A/es not_active Application Discontinuation
- 2003-10-08 WO PCT/CN2003/000849 patent/WO2004103343A1/zh not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7648711B2 (en) | 2010-01-19 |
| AU2003275509A1 (en) | 2004-12-13 |
| EP1634584A1 (en) | 2006-03-15 |
| US20070053943A1 (en) | 2007-03-08 |
| WO2004103343A1 (fr) | 2004-12-02 |
| MXPA05012791A (es) | 2006-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0318319A (pt) | métodos de preparação e formulações/composições sustentadas pelo uso de dimeticona como veìculo | |
| US5976566A (en) | Non-steroidal antiinflammtory drug formulations for topical application to the skin | |
| US11696909B2 (en) | Pain-relieving topical compositions | |
| AU2010257466B2 (en) | Epidermal growth factor composition, a process therefor and its application | |
| AU2003205887B2 (en) | Long acting parasiticidal composition containing a salicylanilide compound, a polymeric species and at least one other anti-parasitic compound | |
| AR065318A1 (es) | Formulaciones liquidas de formacion de pelicula dermal para liberacion de droga a la piel | |
| HUP0100606A2 (hu) | Keményített ricinusolajat tartalmazó tartós hatású injektálható készítmény | |
| US20200405660A1 (en) | Transdermal formulation for the treatment of pain and/or inflammation | |
| BR0312007A (pt) | Controle de taxa de administração transcutânea usando composições farmacêuticas amorfas | |
| CY1111874T1 (el) | Ενεσιμη χορηγηση αριπιπραζολης | |
| BRPI0418098A (pt) | formulações veterinárias não contendo produtos animais | |
| PT1522219E (pt) | FORMULAÃES ANTIPARASITáRIAS | |
| WO2010015665A3 (en) | Parenteral composition comprising microspheres with a diameter between 10 and 20 microns | |
| WO2008067991A2 (en) | Skin-friendly drug complexes for transdermal administration | |
| MXPA04009819A (es) | Reduccion de crecimiento de vello. | |
| AU627610B2 (en) | Long active injectable formulations containing triacetin | |
| CA2660894C (en) | Film-delivering rinse | |
| DE69229318D1 (de) | Hydrierte Rizinusöl-enthaltende injizierbare Formulierungen mit verlängerter Wirkstoffabgabe | |
| US20170232026A1 (en) | Pharmaceutical composition in ivermectin emulgel for veterinary use as a promoter system and bio-adhesive in antiparasitic treatment, and method for the production thereof | |
| MXPA05013270A (es) | Forma de administracion transmucosal con irritacion mucosal reducida. reducida. | |
| PT1305057E (pt) | Composicao de biomateria microparticular para uso medicinal | |
| BRPI0412453A (pt) | uso do ácido ascórbico ou um sal fisiologicamente aceitável do mesmo | |
| CA1263602A (en) | Transdermal delivery of azatadine | |
| BRPI0411954A (pt) | nanopartìculas de derivados poli-oxietilenados e respectivo método de preparação | |
| GB2386067A (en) | Long-acting parasiticidal composition with improved bioavailability comprising an avermectin or milbemycin, plus a salicylanilide & a polymeric species |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |