BR112012004105A2 - pró-fármacos de bisfosfonato - Google Patents
pró-fármacos de bisfosfonatoInfo
- Publication number
- BR112012004105A2 BR112012004105A2 BR112012004105A BR112012004105A BR112012004105A2 BR 112012004105 A2 BR112012004105 A2 BR 112012004105A2 BR 112012004105 A BR112012004105 A BR 112012004105A BR 112012004105 A BR112012004105 A BR 112012004105A BR 112012004105 A2 BR112012004105 A2 BR 112012004105A2
- Authority
- BR
- Brazil
- Prior art keywords
- bisphosphonate prodrugs
- bisphosphonate
- prodrugs
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title 1
- 150000004663 bisphosphonates Chemical class 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09010871A EP2289558A1 (en) | 2009-08-25 | 2009-08-25 | Bisphosphonate-prodrugs |
| PCT/EP2010/005187 WO2011023367A2 (en) | 2009-08-25 | 2010-08-24 | Bisphosphonate-prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012004105A2 true BR112012004105A2 (pt) | 2017-06-20 |
Family
ID=41396494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004105A BR112012004105A2 (pt) | 2009-08-25 | 2010-08-24 | pró-fármacos de bisfosfonato |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8778914B2 (pt) |
| EP (3) | EP2289558A1 (pt) |
| CN (1) | CN102665767B (pt) |
| BR (1) | BR112012004105A2 (pt) |
| WO (1) | WO2011023367A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6029596B2 (ja) * | 2011-02-24 | 2016-11-24 | ケイテーベー ツモルフォルシュングスゲゼルシャフト ミット ベシュレンクテル ハフツング | ビスホスホネートプロドラッグ |
| FR2973378B1 (fr) * | 2011-03-28 | 2013-10-04 | Atlanthera | Derives d'acide hydroxybisphosphonique bifonctionnels |
| EP2899201B1 (en) | 2012-09-19 | 2019-09-11 | Gemvax & Kael Co., Ltd. | Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate |
| WO2015021044A1 (en) * | 2013-08-05 | 2015-02-12 | University Of Rochester | Compositions and methods for stimuli-responsive release of a therapeutic agent |
| GB201319363D0 (en) | 2013-11-01 | 2013-12-18 | Uni I Oslo | Compounds |
| US9499800B2 (en) * | 2013-12-26 | 2016-11-22 | Regents Of The University Of Minnesota | Methods of making and using chemically self assembled-nanorings |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| FR3028762B1 (fr) | 2014-11-20 | 2017-01-06 | Atlanthera | Derives hydroxybisphosphoniques hydrosolubles de la doxorubicine |
| US11384104B2 (en) * | 2015-06-19 | 2022-07-12 | Centurion Biopharma Corporation | Delivery systems for controlled drug release |
| IL305268A (en) | 2017-11-30 | 2023-10-01 | Centurion Biopharma Corp | Maytansinoid-based drug delivery systems |
| BR112020009836A2 (pt) | 2017-11-30 | 2020-10-13 | Centurion Biopharma Corporation | pró-drogas de ligação a albumina de derivados de auristatina e |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ336924A (en) * | 1997-02-13 | 2001-06-29 | Bone Care Int Inc | Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate |
| US6214812B1 (en) * | 1998-04-02 | 2001-04-10 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| US8586781B2 (en) * | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
| DE19926154A1 (de) * | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| DE19926475A1 (de) * | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
| DE10012120A1 (de) * | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| EP1383510B1 (en) | 2001-04-10 | 2012-10-17 | MBC Pharma, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| DE10310082A1 (de) * | 2003-03-07 | 2004-09-16 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Doxorubicin-Peptid-Derivate |
| US20070225258A1 (en) | 2006-02-06 | 2007-09-27 | Proprius Pharmaceuticals, Inc. | Compositions comprising bisphosphonate and an antifolate |
| EP2097440A4 (en) | 2006-12-22 | 2010-09-08 | Targanta Therapeutics Inc | ANTIBIOTICS BASED ON GLYCOPEPTIDES AND LIPOGLYCOPEPTIDES PHOSPHONES AND THEIR USES IN THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS |
| EP2606911A1 (en) * | 2007-02-16 | 2013-06-26 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| AU2008214801B2 (en) * | 2007-02-16 | 2014-02-27 | Ktb Tumorforschungsgesellschaft Mbh | Dual acting prodrugs |
| FR2926081B1 (fr) * | 2008-01-03 | 2010-02-19 | Univ Nantes | Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux |
| EP2268315B1 (en) * | 2008-03-31 | 2019-07-31 | Freie Universität Berlin | Drug conjugates with polyglycerols |
| WO2009141823A2 (en) * | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
-
2009
- 2009-08-25 EP EP09010871A patent/EP2289558A1/en not_active Withdrawn
-
2010
- 2010-08-24 BR BR112012004105A patent/BR112012004105A2/pt not_active Application Discontinuation
- 2010-08-24 US US13/391,367 patent/US8778914B2/en not_active Expired - Fee Related
- 2010-08-24 EP EP10749610.1A patent/EP2470215B1/en not_active Not-in-force
- 2010-08-24 EP EP18000378.2A patent/EP3384937A3/en not_active Withdrawn
- 2010-08-24 CN CN201080037761.4A patent/CN102665767B/zh not_active Expired - Fee Related
- 2010-08-24 WO PCT/EP2010/005187 patent/WO2011023367A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011023367A3 (en) | 2011-08-18 |
| EP2289558A1 (en) | 2011-03-02 |
| EP3384937A3 (en) | 2019-01-16 |
| EP2470215A2 (en) | 2012-07-04 |
| WO2011023367A2 (en) | 2011-03-03 |
| EP2470215B1 (en) | 2018-04-25 |
| EP3384937A2 (en) | 2018-10-10 |
| US20120165296A1 (en) | 2012-06-28 |
| CN102665767B (zh) | 2016-05-04 |
| US8778914B2 (en) | 2014-07-15 |
| CN102665767A (zh) | 2012-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/00 (2006.01), A61P 35/00 (2006.01) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |