BRPI1005525A2 - compostos de azaazuleno - Google Patents
compostos de azaazulenoInfo
- Publication number
- BRPI1005525A2 BRPI1005525A2 BRPI1005525A BRPI1005525A BRPI1005525A2 BR PI1005525 A2 BRPI1005525 A2 BR PI1005525A2 BR PI1005525 A BRPI1005525 A BR PI1005525A BR PI1005525 A BRPI1005525 A BR PI1005525A BR PI1005525 A2 BRPI1005525 A2 BR PI1005525A2
- Authority
- BR
- Brazil
- Prior art keywords
- azaazulene compounds
- azaazulene
- compounds
- Prior art date
Links
- LMBQFLQKKMVTMV-UHFFFAOYSA-N cyclohepta[b]pyrrole Chemical class C1=CC=CC2=NC=CC2=C1 LMBQFLQKKMVTMV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17388309P | 2009-04-29 | 2009-04-29 | |
| PCT/CN2010/072342 WO2010124648A1 (en) | 2009-04-29 | 2010-04-29 | Azaazulene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1005525A2 true BRPI1005525A2 (pt) | 2016-02-23 |
Family
ID=43030852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1005525A BRPI1005525A2 (pt) | 2009-04-29 | 2010-04-29 | compostos de azaazuleno |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8492374B2 (pt) |
| EP (1) | EP2491025B1 (pt) |
| JP (1) | JP5538522B2 (pt) |
| KR (1) | KR101278826B1 (pt) |
| CN (1) | CN102405217B (pt) |
| AU (1) | AU2010244019B2 (pt) |
| BR (1) | BRPI1005525A2 (pt) |
| CA (1) | CA2747420C (pt) |
| ES (1) | ES2443870T3 (pt) |
| IL (1) | IL213019A (pt) |
| MX (1) | MX2011006290A (pt) |
| NZ (1) | NZ593004A (pt) |
| RU (1) | RU2524202C9 (pt) |
| TW (1) | TWI410418B (pt) |
| WO (1) | WO2010124648A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5712524B2 (ja) * | 2009-10-28 | 2015-05-07 | Jsr株式会社 | 液晶配向剤および液晶表示素子 |
| KR102015402B1 (ko) | 2010-05-20 | 2019-08-28 | 어레이 바이오파마 인크. | Trk 키나제 저해제로서의 매크로시클릭 화합물 |
| CN102558096B (zh) * | 2010-12-30 | 2015-01-21 | 达兴材料股份有限公司 | 芳香族二胺化合物、使用此芳香族二胺化合物制备的聚酰胺酸与聚酰亚胺以及液晶配向剂 |
| MX348131B (es) * | 2011-02-25 | 2017-05-26 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos. |
| GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
| JP5949070B2 (ja) * | 2012-04-03 | 2016-07-06 | Jsr株式会社 | 液晶配向剤、液晶配向膜及び液晶表示素子 |
| TWI443096B (zh) * | 2012-12-18 | 2014-07-01 | Ind Tech Res Inst | ３－（５－（４－（３－氟丙基）哌嗪－１－基）苯並咪唑－２－基）－１－氮雜薁－２－酮之單水合晶型及其製備方法與藥學組成物 |
| RU2700703C2 (ru) * | 2014-10-28 | 2019-09-19 | Сионоги Энд Ко., Лтд. | Гетероциклическое производное, обладающее активирующей ampk активностью |
| HUE053067T2 (hu) | 2015-07-16 | 2021-06-28 | Array Biopharma Inc | Helyettesített pirazolo[1,5-A]piridin vegyületek, mint RET kináz inhibitorok |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2019034538A1 (en) * | 2017-08-18 | 2019-02-21 | Universität Regensburg | SYNTHESIS, PHARMACOLOGY AND USE OF NEW FMS FLT3 TYROSINE KINASE 3 (FLT3) SELECTIVE INHIBITORS |
| BR112020006599B1 (pt) * | 2017-10-04 | 2024-02-20 | Celgene Corporation | Cápsulas compreendendo cis-4-[2-{[(3s,4r)-3-fluoro-oxan-4-il]amino}-8-(2,4,6-tricl oroanilino)-9h-purin-9-il]-1-metilciclohexano-1-carb oxamida |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物 |
| PT3860998T (pt) | 2018-10-05 | 2024-04-02 | Annapurna Bio Inc | Compostos e composições para o tratamento de condições associadas à atividade do recetor apj |
| EP3966208A4 (en) * | 2019-05-10 | 2024-01-03 | Antidote IP Holdings, LLC | COMPOUNDS AND METHODS OF TREATING CANCER |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3113950A (en) * | 1960-05-06 | 1963-12-10 | Sankyo Co | Process for the preparation of cyclohepta [b] pyrrol-8(1h)-one derivatives |
| US3230234A (en) * | 1960-05-06 | 1966-01-18 | Sankyo Co | Process for the preparation of 2, 3-dihydro-1h-cyclohepta [b] pyrrole-2, 8-dione derivatives and products thereof |
| US3311641A (en) * | 1963-06-22 | 1967-03-28 | Sankyo Co | Hydrohalides of novel cyclohepta[b]-pyrrole derivatives and a process for preparing the same as well as intermediates and process for their preparations |
| US4337265A (en) * | 1981-08-21 | 1982-06-29 | Ayerst, Mckenna & Harrison Inc. | Cyclohepta[b]pyrrole derivatives |
| JPH02178263A (ja) * | 1988-12-27 | 1990-07-11 | Kaken Pharmaceut Co Ltd | アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤 |
| EP0376233B1 (en) | 1988-12-29 | 1996-03-20 | Seiko Instruments Inc. | Driving system for a display device |
| USRE34198E (en) * | 1989-03-10 | 1993-03-23 | Gate Pallet Systems, Inc. | Corrugated construction pallet |
| KR100681724B1 (ko) * | 1999-10-19 | 2007-02-28 | 머크 앤드 캄파니 인코포레이티드 | 티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물 |
| US6794393B1 (en) * | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP2003512353A (ja) * | 1999-10-19 | 2003-04-02 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
| WO2001057018A1 (en) | 2000-02-02 | 2001-08-09 | Abbott Laboratories | Azaazulene inhibitors of p38 map kinase and tnf-alpha |
| JP4361727B2 (ja) | 2000-09-11 | 2009-11-11 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | チロシンキナーゼインヒビターとしてのキノリノン誘導体 |
| US7064215B2 (en) * | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
| CA2496164C (en) | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
| DE602004019118D1 (de) * | 2003-09-17 | 2009-03-05 | Janssen Pharmaceutica Nv | Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors |
| WO2005082340A2 (en) | 2004-02-20 | 2005-09-09 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
| TW200605885A (en) | 2004-07-29 | 2006-02-16 | Threshold Pharmaceuticals Inc | Multicyclic lonidamine analogs |
| WO2006124413A2 (en) | 2005-05-13 | 2006-11-23 | Novartis Ag | Methods for treating drug resistant cancer |
| RU2008150752A (ru) * | 2006-05-26 | 2010-07-10 | Новартис АГ (CH) | Ингибиторы альдостеронсинтазы и/или 11-гидроксилазы |
| JP4937881B2 (ja) * | 2006-11-01 | 2012-05-23 | 財団法人工業技術研究院 | アズレン化合物 |
| US20100222547A1 (en) * | 2007-03-01 | 2010-09-02 | Mallinckrodt Inc. | Integrated Photoactive Peptides and Uses Thereof |
| RU2009136669A (ru) | 2007-03-09 | 2011-04-20 | Новартис АГ (CH) | Лечение меланомы |
| WO2008150899A1 (en) | 2007-05-29 | 2008-12-11 | Emory University | Combination therapies for treatment of cancer and inflammatory diseases |
-
2010
- 2010-04-28 TW TW099113435A patent/TWI410418B/zh active
- 2010-04-28 US US12/768,869 patent/US8492374B2/en active Active
- 2010-04-29 WO PCT/CN2010/072342 patent/WO2010124648A1/en not_active Ceased
- 2010-04-29 NZ NZ593004A patent/NZ593004A/xx unknown
- 2010-04-29 CA CA2747420A patent/CA2747420C/en active Active
- 2010-04-29 RU RU2011122916/04A patent/RU2524202C9/ru active
- 2010-04-29 KR KR1020117013446A patent/KR101278826B1/ko active Active
- 2010-04-29 CN CN201080010989.4A patent/CN102405217B/zh active Active
- 2010-04-29 MX MX2011006290A patent/MX2011006290A/es active IP Right Grant
- 2010-04-29 EP EP10769337.6A patent/EP2491025B1/en active Active
- 2010-04-29 BR BRPI1005525A patent/BRPI1005525A2/pt not_active IP Right Cessation
- 2010-04-29 ES ES10769337.6T patent/ES2443870T3/es active Active
- 2010-04-29 AU AU2010244019A patent/AU2010244019B2/en active Active
- 2010-04-29 JP JP2012505041A patent/JP5538522B2/ja active Active
-
2011
- 2011-05-19 IL IL213019A patent/IL213019A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2747420A1 (en) | 2010-11-04 |
| WO2010124648A1 (en) | 2010-11-04 |
| ES2443870T3 (es) | 2014-02-20 |
| KR20110098738A (ko) | 2011-09-01 |
| JP5538522B2 (ja) | 2014-07-02 |
| IL213019A0 (en) | 2011-07-31 |
| EP2491025A1 (en) | 2012-08-29 |
| AU2010244019B2 (en) | 2012-05-10 |
| KR101278826B1 (ko) | 2013-06-25 |
| US8492374B2 (en) | 2013-07-23 |
| AU2010244019A1 (en) | 2010-11-04 |
| IL213019A (en) | 2014-07-31 |
| RU2011122916A (ru) | 2013-06-10 |
| NZ593004A (en) | 2013-05-31 |
| RU2524202C9 (ru) | 2015-06-10 |
| MX2011006290A (es) | 2011-09-28 |
| CN102405217B (zh) | 2014-06-11 |
| EP2491025B1 (en) | 2013-11-27 |
| CA2747420C (en) | 2013-09-10 |
| TWI410418B (zh) | 2013-10-01 |
| TW201038556A (en) | 2010-11-01 |
| EP2491025A4 (en) | 2013-01-23 |
| JP2012524032A (ja) | 2012-10-11 |
| CN102405217A (zh) | 2012-04-04 |
| RU2524202C2 (ru) | 2014-07-27 |
| US20100280012A1 (en) | 2010-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |