BRPI1005525A2 - compostos de azaazuleno - Google Patents
compostos de azaazulenoInfo
- Publication number
- BRPI1005525A2 BRPI1005525A2 BRPI1005525A BRPI1005525A BRPI1005525A2 BR PI1005525 A2 BRPI1005525 A2 BR PI1005525A2 BR PI1005525 A BRPI1005525 A BR PI1005525A BR PI1005525 A BRPI1005525 A BR PI1005525A BR PI1005525 A2 BRPI1005525 A2 BR PI1005525A2
- Authority
- BR
- Brazil
- Prior art keywords
- azaazulene compounds
- azaazulene
- compounds
- Prior art date
Links
- LMBQFLQKKMVTMV-UHFFFAOYSA-N cyclohepta[b]pyrrole Chemical class C1=CC=CC2=NC=CC2=C1 LMBQFLQKKMVTMV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17388309P | 2009-04-29 | 2009-04-29 | |
| PCT/CN2010/072342 WO2010124648A1 (en) | 2009-04-29 | 2010-04-29 | Azaazulene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1005525A2 true BRPI1005525A2 (pt) | 2016-02-23 |
Family
ID=43030852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1005525A BRPI1005525A2 (pt) | 2009-04-29 | 2010-04-29 | compostos de azaazuleno |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8492374B2 (pt) |
| EP (1) | EP2491025B1 (pt) |
| JP (1) | JP5538522B2 (pt) |
| KR (1) | KR101278826B1 (pt) |
| CN (1) | CN102405217B (pt) |
| AU (1) | AU2010244019B2 (pt) |
| BR (1) | BRPI1005525A2 (pt) |
| CA (1) | CA2747420C (pt) |
| ES (1) | ES2443870T3 (pt) |
| IL (1) | IL213019A (pt) |
| MX (1) | MX2011006290A (pt) |
| NZ (1) | NZ593004A (pt) |
| RU (1) | RU2524202C9 (pt) |
| TW (1) | TWI410418B (pt) |
| WO (1) | WO2010124648A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5712524B2 (ja) * | 2009-10-28 | 2015-05-07 | Jsr株式会社 | 液晶配向剤および液晶表示素子 |
| RU2735545C2 (ru) | 2010-05-20 | 2020-11-03 | Эррэй Биофарма Инк. | Макроциклические соединения в качестве ингибиторов киназы trk |
| CN102558096B (zh) * | 2010-12-30 | 2015-01-21 | 达兴材料股份有限公司 | 芳香族二胺化合物、使用此芳香族二胺化合物制备的聚酰胺酸与聚酰亚胺以及液晶配向剂 |
| CA2826649C (en) * | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
| JP5949070B2 (ja) * | 2012-04-03 | 2016-07-06 | Jsr株式会社 | 液晶配向剤、液晶配向膜及び液晶表示素子 |
| TWI443096B (zh) * | 2012-12-18 | 2014-07-01 | Ind Tech Res Inst | ３－（５－（４－（３－氟丙基）哌嗪－１－基）苯並咪唑－２－基）－１－氮雜薁－２－酮之單水合晶型及其製備方法與藥學組成物 |
| KR20170077131A (ko) * | 2014-10-28 | 2017-07-05 | 시오노기세야쿠 가부시키가이샤 | Ampk 활성화 작용을 갖는 복소환 유도체 |
| PT3322706T (pt) | 2015-07-16 | 2021-03-08 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]piridina substituídos como inibidores da quinase do ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| JP6888101B2 (ja) | 2017-01-18 | 2021-06-16 | アレイ バイオファーマ インコーポレイテッド | ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2019034538A1 (en) * | 2017-08-18 | 2019-02-21 | Universität Regensburg | SYNTHESIS, PHARMACOLOGY AND USE OF NEW FMS FLT3 TYROSINE KINASE 3 (FLT3) SELECTIVE INHIBITORS |
| KR20200062270A (ko) * | 2017-10-04 | 2020-06-03 | 셀진 코포레이션 | 시스-4-[2-｛[(3s,4r)-3-플루오로옥산-4-일]아미노｝-8-(2,4,6-트리클로로아닐리노)-9h-퓨린-9-일]-1-메틸시클로헥산-1-카르복스아미드의 조성물 및 이용 방법 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| JP6997876B2 (ja) | 2018-01-18 | 2022-02-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物 |
| CA3111984A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| WO2020231739A2 (en) * | 2019-05-10 | 2020-11-19 | Antidote Ip Holdings, Llc | Compounds and methods for treating cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3230234A (en) | 1960-05-06 | 1966-01-18 | Sankyo Co | Process for the preparation of 2, 3-dihydro-1h-cyclohepta [b] pyrrole-2, 8-dione derivatives and products thereof |
| US3113950A (en) | 1960-05-06 | 1963-12-10 | Sankyo Co | Process for the preparation of cyclohepta [b] pyrrol-8(1h)-one derivatives |
| US3311641A (en) | 1963-06-22 | 1967-03-28 | Sankyo Co | Hydrohalides of novel cyclohepta[b]-pyrrole derivatives and a process for preparing the same as well as intermediates and process for their preparations |
| US4337265A (en) | 1981-08-21 | 1982-06-29 | Ayerst, Mckenna & Harrison Inc. | Cyclohepta[b]pyrrole derivatives |
| JPH02178263A (ja) * | 1988-12-27 | 1990-07-11 | Kaken Pharmaceut Co Ltd | アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤 |
| EP0376233B1 (en) | 1988-12-29 | 1996-03-20 | Seiko Instruments Inc. | Driving system for a display device |
| USRE34198E (en) * | 1989-03-10 | 1993-03-23 | Gate Pallet Systems, Inc. | Corrugated construction pallet |
| WO2001028993A2 (en) | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Tyrosine kinase inhibitors |
| US6794393B1 (en) | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| DZ3223A1 (fr) | 1999-10-19 | 2001-04-26 | Merck & Co Inc | Inhibiteurs de tyrosine kinases |
| WO2001057018A1 (en) | 2000-02-02 | 2001-08-09 | Abbott Laboratories | Azaazulene inhibitors of p38 map kinase and tnf-alpha |
| PL211125B1 (pl) | 2000-09-11 | 2012-04-30 | Novartis Vaccines & Diagnostic | Pochodne chinolinonu jako inhibitory kinazy tyrozynowej, kompozycje je zawierające i ich zastosowanie |
| JP2004536113A (ja) | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン／スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
| BR0313743A (pt) | 2002-08-23 | 2005-07-05 | Chiron Corp | Benzimidazol quinolinonas e usos destas |
| MXPA06003150A (es) * | 2003-09-17 | 2006-08-31 | Johnson & Johnson | Compuestos heterociclicos fusionados. |
| US7875624B2 (en) | 2004-02-20 | 2011-01-25 | Novartis Vaccines And Diagnostics, Inc. | Modulating and measuring cellular adhesion |
| WO2006015191A2 (en) | 2004-07-29 | 2006-02-09 | Threshold Pharmaceuticals, Inc. | Multicyclic lonidamine analogs |
| CN101222850B (zh) | 2005-05-13 | 2012-10-03 | 诺瓦提斯公司 | 治疗对药物有抗性的癌症的方法 |
| CN101448832A (zh) * | 2006-05-26 | 2009-06-03 | 诺瓦提斯公司 | 醛固酮合酶和/或11β-羟化酶抑制剂 |
| JP4937881B2 (ja) * | 2006-11-01 | 2012-05-23 | 財団法人工業技術研究院 | アズレン化合物 |
| JP2010519338A (ja) | 2007-03-01 | 2010-06-03 | マリンクロット インコーポレイテッド | 組込み型光活性ペプチドおよびその使用 |
| WO2008112509A1 (en) | 2007-03-09 | 2008-09-18 | Novartis Ag | Treatment of melanoma |
| WO2008150899A1 (en) | 2007-05-29 | 2008-12-11 | Emory University | Combination therapies for treatment of cancer and inflammatory diseases |
-
2010
- 2010-04-28 TW TW099113435A patent/TWI410418B/zh active
- 2010-04-28 US US12/768,869 patent/US8492374B2/en active Active
- 2010-04-29 CA CA2747420A patent/CA2747420C/en active Active
- 2010-04-29 ES ES10769337.6T patent/ES2443870T3/es active Active
- 2010-04-29 MX MX2011006290A patent/MX2011006290A/es active IP Right Grant
- 2010-04-29 NZ NZ593004A patent/NZ593004A/xx unknown
- 2010-04-29 BR BRPI1005525A patent/BRPI1005525A2/pt not_active IP Right Cessation
- 2010-04-29 RU RU2011122916/04A patent/RU2524202C9/ru active
- 2010-04-29 WO PCT/CN2010/072342 patent/WO2010124648A1/en not_active Ceased
- 2010-04-29 EP EP10769337.6A patent/EP2491025B1/en active Active
- 2010-04-29 AU AU2010244019A patent/AU2010244019B2/en active Active
- 2010-04-29 CN CN201080010989.4A patent/CN102405217B/zh active Active
- 2010-04-29 KR KR1020117013446A patent/KR101278826B1/ko active Active
- 2010-04-29 JP JP2012505041A patent/JP5538522B2/ja active Active
-
2011
- 2011-05-19 IL IL213019A patent/IL213019A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010124648A1 (en) | 2010-11-04 |
| IL213019A (en) | 2014-07-31 |
| AU2010244019A1 (en) | 2010-11-04 |
| CA2747420A1 (en) | 2010-11-04 |
| CN102405217A (zh) | 2012-04-04 |
| CN102405217B (zh) | 2014-06-11 |
| CA2747420C (en) | 2013-09-10 |
| JP5538522B2 (ja) | 2014-07-02 |
| RU2524202C2 (ru) | 2014-07-27 |
| TWI410418B (zh) | 2013-10-01 |
| TW201038556A (en) | 2010-11-01 |
| IL213019A0 (en) | 2011-07-31 |
| KR20110098738A (ko) | 2011-09-01 |
| AU2010244019B2 (en) | 2012-05-10 |
| NZ593004A (en) | 2013-05-31 |
| EP2491025A1 (en) | 2012-08-29 |
| JP2012524032A (ja) | 2012-10-11 |
| RU2011122916A (ru) | 2013-06-10 |
| US20100280012A1 (en) | 2010-11-04 |
| EP2491025A4 (en) | 2013-01-23 |
| ES2443870T3 (es) | 2014-02-20 |
| EP2491025B1 (en) | 2013-11-27 |
| RU2524202C9 (ru) | 2015-06-10 |
| MX2011006290A (es) | 2011-09-28 |
| KR101278826B1 (ko) | 2013-06-25 |
| US8492374B2 (en) | 2013-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |