BR112012014405A2 - micropartículas de tobramicina para inalação - Google Patents

micropartículas de tobramicina para inalação

Info

Publication number
BR112012014405A2
BR112012014405A2 BR112012014405A BR112012014405A BR112012014405A2 BR 112012014405 A2 BR112012014405 A2 BR 112012014405A2 BR 112012014405 A BR112012014405 A BR 112012014405A BR 112012014405 A BR112012014405 A BR 112012014405A BR 112012014405 A2 BR112012014405 A2 BR 112012014405A2
Authority
BR
Brazil
Prior art keywords
tobramycin
microparticles
inhalation
tobramycin microparticles
Prior art date
Application number
BR112012014405A
Other languages
English (en)
Other versions
BR112012014405B1 (pt
Inventor
David Morton
Rossella Musa
Tony Qi Zhou
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BR112012014405A2 publication Critical patent/BR112012014405A2/pt
Publication of BR112012014405B1 publication Critical patent/BR112012014405B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112012014405-7A 2009-12-14 2010-11-24 Formulação de pó seco, micropartícula, cápsula para uso com um inalador de pó seco, método para preparação de uma micropartícula e uso de uma micropartícula BR112012014405B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09179010.5 2009-12-14
EP09179010 2009-12-14
PCT/EP2010/068109 WO2011073002A1 (en) 2009-12-14 2010-11-24 Antibiotic microparticles for inhalation

Publications (2)

Publication Number Publication Date
BR112012014405A2 true BR112012014405A2 (pt) 2016-06-07
BR112012014405B1 BR112012014405B1 (pt) 2019-05-14

Family

ID=42167353

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012014405-7A BR112012014405B1 (pt) 2009-12-14 2010-11-24 Formulação de pó seco, micropartícula, cápsula para uso com um inalador de pó seco, método para preparação de uma micropartícula e uso de uma micropartícula

Country Status (17)

Country Link
US (1) US10857169B2 (pt)
EP (1) EP2512439B1 (pt)
JP (1) JP5878475B2 (pt)
KR (2) KR20120104235A (pt)
CN (1) CN102655855B (pt)
AU (1) AU2010333173B2 (pt)
BR (1) BR112012014405B1 (pt)
CA (1) CA2784207C (pt)
IL (1) IL220362A (pt)
MX (1) MX2012006799A (pt)
MY (1) MY161083A (pt)
PH (1) PH12012501064B1 (pt)
RU (1) RU2555772C2 (pt)
SG (1) SG181673A1 (pt)
UA (1) UA107095C2 (pt)
WO (1) WO2011073002A1 (pt)
ZA (1) ZA201204342B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2283817T (pt) 2000-11-30 2016-08-22 Vectura Ltd Método de fabrico de partículas para utilização numa composição farmacêutica
PL2567691T3 (pl) * 2011-09-12 2015-05-29 Meiji Seika Pharma Co Ltd Kompozycje wodne obejmujące arbekacynę
WO2013128283A2 (en) * 2012-02-28 2013-09-06 Iceutica Holdings Inc. Bvi Inhalable pharmaceutical compositions
US9763965B2 (en) 2012-04-13 2017-09-19 Glaxosmithkline Intellectual Property Development Limited Aggregate particles
GB201305825D0 (en) * 2013-03-28 2013-05-15 Vectura Ltd New use
FR3044415B1 (fr) * 2015-11-27 2017-12-01 Biomerieux Sa Procede de determination de la reaction d'un microorganisme a son exposition a un antibiotique
CN108982465B (zh) * 2018-06-06 2020-10-02 上海应用技术大学 酒中二氧化硫高通量sers在线检测方法
ES2953293T3 (es) 2018-08-07 2023-11-10 Norton Waterford Ltd Aplicación de espectroscopia Raman para la fabricación de polvos para inhalación
EP4523754A3 (en) 2019-05-24 2025-05-07 Stichting Radboud universitair medisch centrum Improved administration of glycylcyclines
KR20230066364A (ko) 2020-08-14 2023-05-15 노턴 (워터포드) 리미티드 플루티카손 프로피오네이트 및 알부테롤 술페이트의 흡입가능 제제
IT202100031133A1 (it) 2021-12-13 2023-06-13 Zambon Spa Composizione farmaceutica comprendente tigeciclina

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
PT1913939T (pt) * 2000-06-27 2017-07-19 Vectura Ltd Formulações para utilização em dispositivos inalatórios
AU2002220857A1 (en) * 2000-11-30 2002-06-11 Vectura Limited Particles for use in a pharmaceutical composition
AU2211502A (en) * 2000-11-30 2002-06-11 Vectura Ltd Method of making particles for use in a pharmaceutical composition
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US20080214481A1 (en) * 2004-06-18 2008-09-04 Novartis Vaccines And Diagnostics, Inc. Methods of Treatment of Endobronchial Infections
EP1674085A1 (en) 2004-12-22 2006-06-28 Universite Libre De Bruxelles Solid lipidic particles as pharmaceutically acceptable fillers or carriers for inhalation
US20080317850A1 (en) * 2005-04-08 2008-12-25 Ernest Alan Hewitt Buccal Delivery System
EP2050437A1 (en) * 2007-10-15 2009-04-22 Laboratoires SMB Improved pharmaceutical dry powder compositions for inhalation.
WO2010003465A2 (en) * 2008-07-11 2010-01-14 Universita' Degli Studi Di Parma A drug powder for inhalation administration and a process thereof
US20110182960A1 (en) 2008-10-02 2011-07-28 Elisabeth Marianna Wilhelmina Maria Van Dongen Antimicrobial Coating

Also Published As

Publication number Publication date
SG181673A1 (en) 2012-07-30
MX2012006799A (es) 2012-07-23
RU2012126507A (ru) 2014-01-27
KR20180045071A (ko) 2018-05-03
RU2555772C2 (ru) 2015-07-10
PH12012501064B1 (en) 2017-09-27
KR101895759B1 (ko) 2018-09-05
MY161083A (en) 2017-04-14
KR20120104235A (ko) 2012-09-20
IL220362A (en) 2016-11-30
PH12012501064A1 (en) 2017-06-07
CN102655855A (zh) 2012-09-05
JP2013513631A (ja) 2013-04-22
US10857169B2 (en) 2020-12-08
US20110139152A1 (en) 2011-06-16
EP2512439A1 (en) 2012-10-24
WO2011073002A1 (en) 2011-06-23
EP2512439B1 (en) 2016-08-24
HK1173971A1 (en) 2013-05-31
CN102655855B (zh) 2015-03-11
JP5878475B2 (ja) 2016-03-08
AU2010333173B2 (en) 2016-08-25
CA2784207C (en) 2018-06-05
UA107095C2 (uk) 2014-11-25
BR112012014405B1 (pt) 2019-05-14
AU2010333173A1 (en) 2012-07-05
ZA201204342B (en) 2013-08-28
CA2784207A1 (en) 2011-06-23

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2010, OBSERVADAS AS CONDICOES LEGAIS