BR112012017303A2 - variantes de alérgenos do grupo 6 de gramíneas verdadeiras tendo reduzida qualidade alergênica devido a mutagenese de resíduos de prolina - Google Patents

variantes de alérgenos do grupo 6 de gramíneas verdadeiras tendo reduzida qualidade alergênica devido a mutagenese de resíduos de prolina

Info

Publication number
BR112012017303A2
BR112012017303A2 BR112012017303A BR112012017303A BR112012017303A2 BR 112012017303 A2 BR112012017303 A2 BR 112012017303A2 BR 112012017303 A BR112012017303 A BR 112012017303A BR 112012017303 A BR112012017303 A BR 112012017303A BR 112012017303 A2 BR112012017303 A2 BR 112012017303A2
Authority
BR
Brazil
Prior art keywords
allergen
variants
quality due
proline residue
reduced
Prior art date
Application number
BR112012017303A
Other languages
English (en)
Inventor
Andreas Nandy
Bernhard Weber
Gerald Reese
Helga Kahlert
Helmut Fiebig
Martin Wald
Oliver Cromwell
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112012017303A2 publication Critical patent/BR112012017303A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

variantes de alérgenos do grupo 6 de gramíneas verdadeiras tendo reduzida qualidade alergênica devido a mutagenese de resíduos de prolina. a presente invenção refere-se à preparação e ao uso de variantes recombinantes dos alérgenos de grupo 6 da poaceae que são caracterizadas pelo fato que sua reatividade de ige é reduzida em comparação com os conhecidos alérgenos do tipo silvestre enquanto simultaneamente a reatividade com linfócitos de t é largamento retida.
BR112012017303A 2010-01-14 2010-12-17 variantes de alérgenos do grupo 6 de gramíneas verdadeiras tendo reduzida qualidade alergênica devido a mutagenese de resíduos de prolina BR112012017303A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10000293 2010-01-14
PCT/EP2010/007745 WO2011085782A1 (de) 2010-01-14 2010-12-17 Varianten der gruppe 6-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten

Publications (1)

Publication Number Publication Date
BR112012017303A2 true BR112012017303A2 (pt) 2016-04-19

Family

ID=43783681

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012017303A BR112012017303A2 (pt) 2010-01-14 2010-12-17 variantes de alérgenos do grupo 6 de gramíneas verdadeiras tendo reduzida qualidade alergênica devido a mutagenese de resíduos de prolina

Country Status (9)

Country Link
US (2) US8999348B2 (pt)
EP (1) EP2523684A1 (pt)
JP (1) JP5871818B2 (pt)
CN (2) CN105001315A (pt)
AU (1) AU2010342532B2 (pt)
BR (1) BR112012017303A2 (pt)
CA (1) CA2786935A1 (pt)
RU (1) RU2607373C2 (pt)
WO (1) WO2011085782A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025102125A1 (en) * 2023-11-17 2025-05-22 Queensland University Of Technology Modified grass pollen allergens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
DE19918682A1 (de) * 1999-04-23 2000-10-26 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
SE9903950D0 (sv) * 1999-10-29 1999-10-29 Pharmacia & Upjohn Diag Ab Non-anaphylactic forms of grass pollen allergen and their use
EP2392591B1 (de) * 2002-06-25 2018-02-21 Merck Patent GmbH DNA-Sequenz und rekombinante Herstellung des Graspollen-Allergens Phl p 4
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
CN100351664C (zh) * 2005-03-24 2007-11-28 富士能株式会社 变焦镜头

Also Published As

Publication number Publication date
JP5871818B2 (ja) 2016-03-01
AU2010342532B2 (en) 2016-07-21
RU2012134509A (ru) 2014-02-20
CN102811735B (zh) 2015-09-09
WO2011085782A1 (de) 2011-07-21
CA2786935A1 (en) 2011-07-21
US20150071953A1 (en) 2015-03-12
US20130224251A1 (en) 2013-08-29
EP2523684A1 (de) 2012-11-21
CN102811735A (zh) 2012-12-05
JP2013516961A (ja) 2013-05-16
AU2010342532A1 (en) 2012-08-30
US8999348B2 (en) 2015-04-07
CN105001315A (zh) 2015-10-28
RU2607373C2 (ru) 2017-01-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.