BR112012018658A2 - sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preração e seu uso médico - Google Patents

sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preração e seu uso médico

Info

Publication number
BR112012018658A2
BR112012018658A2 BR112012018658A BR112012018658A BR112012018658A2 BR 112012018658 A2 BR112012018658 A2 BR 112012018658A2 BR 112012018658 A BR112012018658 A BR 112012018658A BR 112012018658 A BR112012018658 A BR 112012018658A BR 112012018658 A2 BR112012018658 A2 BR 112012018658A2
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salts
medical use
pyrrole derivatives
nitrogenous heterocyclic
Prior art date
Application number
BR112012018658A
Other languages
English (en)
Inventor
Peng Cho Tang
Original Assignee
Jiangsu Hengrui Medicine Co
Shanghai Hengrui Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co, Shanghai Hengrui Pharm Co Ltd filed Critical Jiangsu Hengrui Medicine Co
Publication of BR112012018658A2 publication Critical patent/BR112012018658A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preparação e seu uso médico. a presente invenção refere-se a sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preparação e seu uso médico são descritos. mais especificamente, sais farmaceuticamente aceitáveis de (r,z)-2-(5-flúor-2-oxo-1,2-di-hidro-indol-3-imetileno)-5-(2-hidróxi-3-morfolinil-4-il-propil)-3-metil--5,6,7,8-tetraidro-1h--pirrolo[3,2-c] azepin-4-ona apresentadfa pela fórmula (i) o processo de preparação e seu uso como agentes terapêuticos, especialmente como inibidores de proteína quinase, são descritos.
BR112012018658A 2010-02-04 2011-01-07 sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preração e seu uso médico BR112012018658A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010101090685A CN102146082A (zh) 2010-02-04 2010-02-04 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
PCT/CN2011/070076 WO2011095068A1 (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
BR112012018658A2 true BR112012018658A2 (pt) 2016-05-03

Family

ID=44354948

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012018658A BR112012018658A2 (pt) 2010-02-04 2011-01-07 sais farmaceuticamente aceitáveis de derivados heterocíclicos nitrogenosos - pirrolo, processo de preração e seu uso médico

Country Status (11)

Country Link
US (1) US20120295887A1 (pt)
EP (1) EP2532666A1 (pt)
JP (1) JP2013518828A (pt)
KR (1) KR20120130089A (pt)
CN (2) CN102146082A (pt)
AU (1) AU2011213440A1 (pt)
BR (1) BR112012018658A2 (pt)
CA (1) CA2786927A1 (pt)
MX (1) MX2012008611A (pt)
RU (1) RU2012136378A (pt)
WO (1) WO2011095068A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN112778187B (zh) * 2021-01-06 2022-10-28 烟台舜康生物科技有限公司 一种海那替尼中间体的合成方法及所得的海纳替尼中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001241798A1 (en) * 2000-02-28 2001-09-12 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
PL1973910T3 (pl) * 2006-01-27 2013-11-29 Shanghai hengrui pharmaceutical co ltd Pirolo[3,2-c]pirydyn-4-onowo-2-indolinonowe inhibitory kinazy białkowej
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
WO2008138232A1 (en) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co., Ltd. Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof

Also Published As

Publication number Publication date
KR20120130089A (ko) 2012-11-28
MX2012008611A (es) 2012-08-15
RU2012136378A (ru) 2014-03-10
CN102146082A (zh) 2011-08-10
WO2011095068A1 (zh) 2011-08-11
CN102421781A (zh) 2012-04-18
US20120295887A1 (en) 2012-11-22
AU2011213440A1 (en) 2012-08-09
JP2013518828A (ja) 2013-05-23
CA2786927A1 (en) 2011-08-11
EP2532666A1 (en) 2012-12-12

Similar Documents

Publication Publication Date Title
CY1124117T1 (el) Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων
EA201001368A1 (ru) Гетероциклические производные мочевины и способы их применения-211
EA201391239A1 (ru) Пирроло[2,3-d]пиримидиновые производные в качестве ингибиторов тропомиозин-связанных киназ
EA201491671A1 (ru) Гетероциклильные соединения
EA201201680A1 (ru) Морфолинопиримидины и их применение в терапии
EA201100613A1 (ru) Конденсированные, спироциклические гетероароматические соединения для лечения бактериальных инфекций
CO6382125A2 (es) Inhibidores de proteína quinasa
UA99141C2 (ru) Замещенные производные индазола, активные в качестве ингибиторов киназы
CO6680717A2 (es) Derivados de quinolina y quinoxalina como inhibidores de cinasa
EA201591195A1 (ru) Новые хинолоновые производные
ATE557015T1 (de) 3,4-diarylpyrazole als proteinkinaseinhibitoren
EA201101618A1 (ru) Арилпиридины в качестве ингибиторов альдостеронсинтазы
ATE514699T1 (de) Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
EA201100971A1 (ru) Производные пиримидининдола для лечения злокачественного новообразования
EA201390198A1 (ru) Гетероциклическое соединение
EA201490471A1 (ru) Пиридазиноновые соединения и их применение в качестве ингибиторов daao
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
EA200900924A1 (ru) Циклизованные производные как ингибиторы eg-5
EA201001858A1 (ru) Гетероциклические производные мочевины для лечения бактериальных инфекций
EA201001859A1 (ru) Гетероциклические производные мочевины и способы их применеия
GEP20166481B (en) (crystalline forms of hydrochloride salt of (4a-r, 9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2, 3, 4, 4a, 9, 9a-hexa- hydro-1h-indeno [2, 1-b] pyridine-6-carbonitrile and their use as hsd 1 inhibitors
BR112015022758A2 (pt) derivados de pirrolidina, composições farmacêuticas contendo os mesmos e seu uso em terapia
UY32856A (es) Derivados heterocíclicos de urea y métodos de uso de los mismos
BR112014012983A2 (pt) derivados de pirrol
EA201291014A1 (ru) Трициклическое индазольное соединение, способ его получения и содержащая его фармацевтическая композиция

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]