BR112015012425A2 - composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto - Google Patents

composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto

Info

Publication number
BR112015012425A2
BR112015012425A2 BR112015012425A BR112015012425A BR112015012425A2 BR 112015012425 A2 BR112015012425 A2 BR 112015012425A2 BR 112015012425 A BR112015012425 A BR 112015012425A BR 112015012425 A BR112015012425 A BR 112015012425A BR 112015012425 A2 BR112015012425 A2 BR 112015012425A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
parp
medicament
protein
Prior art date
Application number
BR112015012425A
Other languages
English (en)
Inventor
K Srivastava Brijesh
R Patel Pankaj
C Desai Ranjit
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54198806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015012425(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of BR112015012425A2 publication Critical patent/BR112015012425A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

resumo “composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto” a presente invenção refere-se a novos compostos de fórmula geral (i), aos seus estereoisômeros, regioisômeros, formas tautoméricas e novos intermediários envolvidos em suas sínteses, os seus sais farmaceuticamente aceitáveis, solvatos farmaceuticamente aceitáveis e composições farmacêuticas contendo os mesmos. a presente invenção também se refere a um processo de preparar novos compostos de fórmula geral (i), os seus estereoisômeros, regioisômeros, as suas formas tautoméricas, os seus sais farmaceuticamente aceitáveis, solvatos farmaceuticamente aceitáveis, composições farmacêuticas contendo os mesmos, e novos intermediários envolvidos em suas sínteses. ?? ?? ?? ?? 1/1
BR112015012425A 2012-12-31 2013-12-23 composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto BR112015012425A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3742MU2012 2012-12-31
PCT/IN2013/000794 WO2014102817A1 (en) 2012-12-31 2013-12-23 Substituted phthalazin-1 (2h)-one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1

Publications (1)

Publication Number Publication Date
BR112015012425A2 true BR112015012425A2 (pt) 2017-07-11

Family

ID=54198806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015012425A BR112015012425A2 (pt) 2012-12-31 2013-12-23 composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto

Country Status (29)

Country Link
US (1) US9598418B2 (pt)
EP (1) EP2938598B1 (pt)
JP (1) JP5930452B2 (pt)
KR (1) KR101652654B1 (pt)
CN (1) CN104918917A (pt)
AP (1) AP2015008439A0 (pt)
AR (1) AR094299A1 (pt)
AU (1) AU2013368842B2 (pt)
BR (1) BR112015012425A2 (pt)
CA (1) CA2890309A1 (pt)
CL (1) CL2015001655A1 (pt)
CO (1) CO7400872A2 (pt)
DK (1) DK2938598T3 (pt)
EA (1) EA201591239A1 (pt)
ES (1) ES2614885T3 (pt)
GE (1) GEP201706691B (pt)
HR (1) HRP20170219T1 (pt)
HU (1) HUE030613T2 (pt)
IL (1) IL238714A0 (pt)
MA (1) MA38080A1 (pt)
MX (1) MX2015006780A (pt)
NZ (1) NZ708255A (pt)
PH (1) PH12015501199B1 (pt)
PL (1) PL2938598T3 (pt)
PT (1) PT2938598T (pt)
SG (1) SG11201503670YA (pt)
TW (1) TWI553005B (pt)
WO (1) WO2014102817A1 (pt)
ZA (1) ZA201503218B (pt)

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MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
US10562886B2 (en) 2015-05-21 2020-02-18 The Regents Of The University Of California Anti-cancer compounds
MX387736B (es) 2015-09-04 2025-03-18 Hoffmann La Roche Derivados de fenoximetilo.
KR20180054634A (ko) * 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
PE20180451A1 (es) * 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
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US20240208912A1 (en) * 2021-03-11 2024-06-27 Mirati Therapeutics, Inc. MTA-Cooperative PRMT5 Inhibitors
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US20240317762A1 (en) * 2021-07-16 2024-09-26 Oregon Health & Science University Phthalazinone-based parp-1 inhibitors
CN118871432A (zh) * 2022-03-15 2024-10-29 百济神州有限公司 作为prmt5的mta协同抑制剂的4-(氨基甲基)-6-(1-甲基-1h-吡唑-4-基)异喹啉-1(2h)-酮衍生物
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KR20140121477A (ko) 2012-02-09 2014-10-15 메르크 파텐트 게엠베하 Ｔａｎｋ 및 ｐａｒｐ 저해체로서의 테트라히드로-퀴나졸리논

Also Published As

Publication number Publication date
PL2938598T3 (pl) 2017-05-31
CN104918917A (zh) 2015-09-16
GEP201706691B (en) 2017-06-26
MA38080A1 (fr) 2018-02-28
MX2015006780A (es) 2015-08-06
AU2013368842B2 (en) 2015-11-12
KR20150091137A (ko) 2015-08-07
TWI553005B (zh) 2016-10-11
WO2014102817A1 (en) 2014-07-03
PH12015501199A1 (en) 2015-08-17
ZA201503218B (en) 2016-01-27
AP2015008439A0 (en) 2015-05-31
CO7400872A2 (es) 2015-09-30
JP5930452B2 (ja) 2016-06-08
NZ708255A (en) 2016-08-26
US20150291603A1 (en) 2015-10-15
EP2938598A1 (en) 2015-11-04
AR094299A1 (es) 2015-07-22
KR101652654B1 (ko) 2016-08-30
CL2015001655A1 (es) 2015-10-02
HK1210466A1 (en) 2016-04-22
SG11201503670YA (en) 2015-07-30
PT2938598T (pt) 2017-02-07
IL238714A0 (en) 2015-07-01
HRP20170219T1 (hr) 2017-04-07
ES2614885T3 (es) 2017-06-02
EP2938598B1 (en) 2016-12-21
TW201441219A (zh) 2014-11-01
AU2013368842A1 (en) 2015-05-21
US9598418B2 (en) 2017-03-21
PH12015501199B1 (en) 2018-01-17
HUE030613T2 (en) 2017-05-29
EA201591239A1 (ru) 2015-10-30
JP2016504347A (ja) 2016-02-12
CA2890309A1 (en) 2014-07-03
DK2938598T3 (en) 2017-02-13

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