MA38080A1 - Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 - Google Patents
Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1Info
- Publication number
- MA38080A1 MA38080A1 MA38080A MA38080A MA38080A1 MA 38080 A1 MA38080 A1 MA 38080A1 MA 38080 A MA38080 A MA 38080A MA 38080 A MA38080 A MA 38080A MA 38080 A1 MA38080 A1 MA 38080A1
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutically acceptable
- adp
- ribose
- polymerase
- poly
- Prior art date
Links
- 101001113483 Homo sapiens Poly [ADP-ribose] polymerase 1 Proteins 0.000 title 1
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 101100407073 Caenorhabditis elegans parp-1 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
La présente invention concerne des nouveaux composés de formule générale (i), leurs stéréoisomères, leurs régioisomères, leurs formes tautomères et des nouveaux intermédiaires impliqués dans leur synthèse, leurs sels pharmaceutiquement acceptables, leurs solvates pharmaceutiquement acceptables et des compositions pharmaceutiques les contenant. La présente invention concerne également un procédé de préparation des nouveaux composés de formule générale (i), de leurs stéréoisomères, de leurs régioisomères, de leurs formes tautomères, de leurs sels pharmaceutiquement acceptables, de leurs solvates pharmaceutiquement acceptables, de compositions pharmaceutiques les contenant et de nouveaux intermédiaires impliqués dans leur synthèse. Les composés de formule (i) sont utiles comme inhibiteurs de parp-1 pour le traitement, par exemple, du cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3742MU2012 | 2012-12-31 | ||
| PCT/IN2013/000794 WO2014102817A1 (fr) | 2012-12-31 | 2013-12-23 | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA38080A1 true MA38080A1 (fr) | 2018-02-28 |
Family
ID=54198806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38080A MA38080A1 (fr) | 2012-12-31 | 2013-12-23 | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9598418B2 (fr) |
| EP (1) | EP2938598B1 (fr) |
| JP (1) | JP5930452B2 (fr) |
| KR (1) | KR101652654B1 (fr) |
| CN (1) | CN104918917A (fr) |
| AP (1) | AP2015008439A0 (fr) |
| AR (1) | AR094299A1 (fr) |
| AU (1) | AU2013368842B2 (fr) |
| BR (1) | BR112015012425A2 (fr) |
| CA (1) | CA2890309A1 (fr) |
| CL (1) | CL2015001655A1 (fr) |
| CO (1) | CO7400872A2 (fr) |
| DK (1) | DK2938598T3 (fr) |
| EA (1) | EA201591239A1 (fr) |
| ES (1) | ES2614885T3 (fr) |
| GE (1) | GEP201706691B (fr) |
| HR (1) | HRP20170219T1 (fr) |
| HU (1) | HUE030613T2 (fr) |
| IL (1) | IL238714A0 (fr) |
| MA (1) | MA38080A1 (fr) |
| MX (1) | MX2015006780A (fr) |
| NZ (1) | NZ708255A (fr) |
| PH (1) | PH12015501199B1 (fr) |
| PL (1) | PL2938598T3 (fr) |
| PT (1) | PT2938598T (fr) |
| SG (1) | SG11201503670YA (fr) |
| TW (1) | TWI553005B (fr) |
| WO (1) | WO2014102817A1 (fr) |
| ZA (1) | ZA201503218B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| KR20160087900A (ko) | 2013-11-26 | 2016-07-22 | 에프. 호프만-라 로슈 아게 | 신규한 옥타하이드로-사이클로부타[1,2-c；3,4-c'']다이피롤-2-일 |
| SI3122750T1 (sl) | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
| EP3298005B1 (fr) | 2015-05-21 | 2024-01-24 | The Regents of The University of California | Composés anti-cancereux |
| JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | フェノキシメチル誘導体 |
| AU2016328365B2 (en) | 2015-09-24 | 2020-04-23 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| RU2018112230A (ru) * | 2015-09-24 | 2019-10-30 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов atx |
| JP6877413B2 (ja) * | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| CN107635995B (zh) | 2015-09-24 | 2022-08-19 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| CN107428762B (zh) * | 2015-10-30 | 2020-03-10 | 四川科伦博泰生物医药股份有限公司 | 酞嗪酮衍生物、其制备方法及用途 |
| WO2017101796A1 (fr) * | 2015-12-16 | 2017-06-22 | 四川科伦博泰生物医药股份有限公司 | Dérivé de phtalazinone, et procédé de préparation et utilisation associés |
| MX387726B (es) * | 2016-06-24 | 2025-03-18 | Univ California | Derivados de ftalazina como inhibidores de parp1, parp2 y/o tubulina útiles para el tratamiento del cáncer. |
| WO2018167113A1 (fr) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
| EP3596059B1 (fr) | 2017-03-16 | 2024-04-24 | F. Hoffmann-La Roche AG | Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
| PT3448859T (pt) | 2017-03-20 | 2019-10-25 | Forma Therapeutics Inc | Composições de pirrolopirrole como ativadores de piruvato quinase (pkr). |
| CN109251204A (zh) * | 2017-07-13 | 2019-01-22 | 中国药科大学 | 含有酞嗪-1(2h)-酮结构的parp抑制剂、其制法及医药用途 |
| CN108164468B (zh) * | 2018-02-09 | 2021-02-02 | 上海卫岑医药科技有限公司 | 一种parp抑制剂、其药物组合物、制备方法及应用 |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
| CN114615977B (zh) | 2019-09-19 | 2025-01-14 | 诺沃挪第克健康护理股份公司 | 丙酮酸激酶r(pkr)活化组合物 |
| US20230159469A1 (en) * | 2020-05-08 | 2023-05-25 | Txinno Bioscience Inc. | Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof |
| WO2022192745A1 (fr) * | 2021-03-11 | 2022-09-15 | Mirati Therapeutics, Inc. | Inhibiteurs de prmt5 coopératif à base de mta |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| US20240317762A1 (en) * | 2021-07-16 | 2024-09-26 | Oregon Health & Science University | Phthalazinone-based parp-1 inhibitors |
| WO2023174250A1 (fr) * | 2022-03-15 | 2023-09-21 | Beigene , Ltd. | Dérivés de 4-(aminométhyl)-6-(1-méthyl-1h-pyrazol-4-yl) isoquinolin-1(2h)-one utilisés comme inhibiteurs de la prmt5 coopérant avec la mta |
| CN119365468A (zh) * | 2022-08-31 | 2025-01-24 | 江苏恒瑞医药股份有限公司 | 稠合二环类化合物、其制备方法及其在医药上的应用 |
| CN116874496B (zh) * | 2023-07-10 | 2025-07-25 | 东南大学 | 三环类化合物及其制备方法、药物组合物和应用 |
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| US6531464B1 (en) | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
| HU228960B1 (hu) | 2000-10-30 | 2013-07-29 | Kudos Pharm Ltd | Ftalazinon-származékok |
| US7449464B2 (en) * | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| BRPI0408284B8 (pt) | 2003-03-12 | 2021-05-25 | Kudos Pharm Ltd | compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos |
| MXPA06007692A (es) | 2004-01-05 | 2007-01-26 | Astrazeneca Ab | Heterociclos sustituidos y usos de los mismos. |
| MX2007002318A (es) | 2004-08-26 | 2007-04-17 | Kudos Pharm Ltd | Derivados de ftalazinona substituidos con 4-heteroarilmetilo. |
| US20060079510A1 (en) | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| MX2007012448A (es) | 2005-04-06 | 2007-10-19 | Astrazeneca Ab | Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak. |
| DE602006020335D1 (de) | 2005-11-25 | 2011-04-07 | Pharma Mar Sa | Verwendung von parp-1-hemmern |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| DK2120579T3 (da) * | 2006-12-28 | 2014-02-03 | Abbvie Inc | Inhibitorer af poly(ADP-ripose)polymerase |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| BRPI0811059A2 (pt) | 2007-05-25 | 2017-05-09 | Astrazeneca Ab | combinação, composição farmacêutica, método para tratar câncer em um animal de sangue quente, e, uso de uma combinação |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| MX2010005070A (es) * | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| ES2598178T5 (es) | 2008-10-07 | 2023-12-26 | Kudos Pharm Ltd | Formulación farmacéutica 514 |
| US8871765B2 (en) | 2010-07-27 | 2014-10-28 | Cadila Healthcare Limited | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors |
| CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372716A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372698A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| WO2012071684A1 (fr) | 2010-12-02 | 2012-06-07 | Shanghai De Novo Pharmatech Co Ltd. | Dérivés hétérocycliques, leurs procédés de préparation et leurs utilisations médicales |
| CN102485721B (zh) | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
| EP2714703B1 (fr) | 2011-05-31 | 2021-03-10 | Newgen Therapeutics, Inc. | Inhibiteurs tricycliques de poly(adp-ribose)polymérase |
| ES2562903T3 (es) | 2011-07-13 | 2016-03-09 | Santen Pharmaceutical Co., Ltd | Nuevo compuesto que tiene actividad inhibidora de PARP |
| US20130053365A1 (en) | 2011-08-30 | 2013-02-28 | Biomarin Pharmaceutical, Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| NZ626937A (en) | 2011-12-31 | 2016-09-30 | Beigene Ltd | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
| CN103242273B (zh) | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
| EP2812323B1 (fr) | 2012-02-09 | 2016-04-06 | Merck Patent GmbH | Dérivés tétrahydro-quinazolinone comme inhibiteurs de tank et de parp |
-
2013
- 2013-12-23 WO PCT/IN2013/000794 patent/WO2014102817A1/fr not_active Ceased
- 2013-12-23 ES ES13828996.2T patent/ES2614885T3/es active Active
- 2013-12-23 BR BR112015012425A patent/BR112015012425A2/pt not_active IP Right Cessation
- 2013-12-23 US US14/647,088 patent/US9598418B2/en not_active Expired - Fee Related
- 2013-12-23 AU AU2013368842A patent/AU2013368842B2/en not_active Ceased
- 2013-12-23 EA EA201591239A patent/EA201591239A1/ru unknown
- 2013-12-23 JP JP2015550210A patent/JP5930452B2/ja not_active Expired - Fee Related
- 2013-12-23 KR KR1020157017355A patent/KR101652654B1/ko not_active Expired - Fee Related
- 2013-12-23 EP EP13828996.2A patent/EP2938598B1/fr not_active Not-in-force
- 2013-12-23 HU HUE13828996A patent/HUE030613T2/en unknown
- 2013-12-23 MA MA38080A patent/MA38080A1/fr unknown
- 2013-12-23 NZ NZ708255A patent/NZ708255A/en not_active IP Right Cessation
- 2013-12-23 PL PL13828996T patent/PL2938598T3/pl unknown
- 2013-12-23 MX MX2015006780A patent/MX2015006780A/es unknown
- 2013-12-23 DK DK13828996.2T patent/DK2938598T3/en active
- 2013-12-23 GE GEAP201313901A patent/GEP201706691B/en unknown
- 2013-12-23 SG SG11201503670YA patent/SG11201503670YA/en unknown
- 2013-12-23 AP AP2015008439A patent/AP2015008439A0/xx unknown
- 2013-12-23 CN CN201380069025.0A patent/CN104918917A/zh active Pending
- 2013-12-23 PT PT138289962T patent/PT2938598T/pt unknown
- 2013-12-23 CA CA2890309A patent/CA2890309A1/fr not_active Abandoned
- 2013-12-26 TW TW102148473A patent/TWI553005B/zh not_active IP Right Cessation
- 2013-12-27 AR ARP130105054A patent/AR094299A1/es unknown
-
2015
- 2015-05-08 ZA ZA2015/03218A patent/ZA201503218B/en unknown
- 2015-05-10 IL IL238714A patent/IL238714A0/en not_active IP Right Cessation
- 2015-05-28 PH PH12015501199A patent/PH12015501199B1/en unknown
- 2015-06-03 CO CO15127891A patent/CO7400872A2/es unknown
- 2015-06-12 CL CL2015001655A patent/CL2015001655A1/es unknown
-
2017
- 2017-02-09 HR HRP20170219TT patent/HRP20170219T1/hr unknown
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| Publication | Publication Date | Title |
|---|---|---|
| MA38080A1 (fr) | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 | |
| MA32135B1 (fr) | Inhibiteurs de pim kinase et leurs procedes d'utilisation | |
| TN2009000450A1 (fr) | Derives de pyridine | |
| MA38138A1 (fr) | Dérivés inédits de quinolone | |
| TN2014000033A1 (fr) | Indazoles | |
| MY155653A (en) | Triazine compounds as p13 kinase and mtor inhibitors | |
| MA31574B1 (fr) | Dérivés de pyrazole et leur utilisation comme inhibiteurs de raf | |
| TN2016000188A1 (fr) | Derives de purines 2,6-substitues et leur utilisation dans le traitement de troubles proliferatifs. | |
| MA37712A2 (fr) | Inhibiteurs macrocycliques de virus flaviviridae | |
| MA41134B1 (fr) | Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales | |
| MA32351B1 (fr) | Derives d'aminodihydrothiazine a titre d'inhibiteurs de bace pour le traitement de la maladie d'alzheimer | |
| MA31170B1 (fr) | Dérivés de 2-amino-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine servant d'inhibiteurs de la hsp-90 pour le traitement du cancer | |
| MA33745B1 (fr) | Piperidines substituees qui accroissent l'activite de p53, et utilisation de ces composes | |
| MA38323B1 (fr) | Dérivés pyrimidone et leur utilisation dans le traitement, l'amélioration ou la prévention d'une maladie virale | |
| MA40225A (fr) | Composés dihydroisoquinolinone substitués | |
| MA29926B1 (fr) | Derives de pyrazine | |
| MA27801A1 (fr) | Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant | |
| TNSN07022A1 (fr) | Derives de pyridine | |
| MA37405A1 (fr) | Composés hétérocyclyle | |
| TN2015000547A1 (fr) | Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1 | |
| MX2008013583A (es) | Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen. | |
| MA31710B1 (fr) | (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament | |
| MX2011012337A (es) | Nuevos derivados de pirimidina y su uso en el tratamiento de cancer y de otras enfermedades. | |
| NZ612909A (en) | Processes for preparing isoquinolinones and solid forms of isoquinolinones | |
| CR20200286A (es) | DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294) |