BR112022008039A2 - Compostos de 4-amino-imidazoquinolina e usos relacionados - Google Patents

Compostos de 4-amino-imidazoquinolina e usos relacionados

Info

Publication number
BR112022008039A2
BR112022008039A2 BR112022008039A BR112022008039A BR112022008039A2 BR 112022008039 A2 BR112022008039 A2 BR 112022008039A2 BR 112022008039 A BR112022008039 A BR 112022008039A BR 112022008039 A BR112022008039 A BR 112022008039A BR 112022008039 A2 BR112022008039 A2 BR 112022008039A2
Authority
BR
Brazil
Prior art keywords
amino
disclosed
allergic disease
related uses
compounds
Prior art date
Application number
BR112022008039A
Other languages
English (en)
Inventor
Chou Yu-Cheng
Original Assignee
Prime Reach Trading Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prime Reach Trading Ltd filed Critical Prime Reach Trading Ltd
Publication of BR112022008039A2 publication Critical patent/BR112022008039A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTOS DE 4-AMINO-IMIDAZOQUINOLINA E USOS RELACIONADOS. São divulgados compostos de 4-amino-imidazoquinolina e usos relacionados. Os compostos da invenção são receptores tipo Toll 7 (TLR7) e agonistas duplos de TLR8, que exibem atividades na indução da expressão de IL-12 e IP-10 sem superindução de IL-6. Os agonistas duplos de TLR 7/8 são medicamentos potencialmente úteis como modificadores da resposta imune. É divulgado o uso de um composto ou sal relacionado, de acordo com a invenção, na fabricação de um medicamento para tratamento de uma doença ou condição em que a ativação de TLR7 e/ou TLR8 proporciona benefícios para um sujeito em necessidade. É divulgado, ainda, um composto ou uma composição farmacêutica para uso no tratamento de uma infecção viral, câncer e/ou uma doença alérgica, ou para uso na ativação de respostas imunes que são eficazes contra uma infecção viral, um tumor e/ou uma doença alérgica em um sujeito em necessidade.
BR112022008039A 2019-10-29 2020-10-20 Compostos de 4-amino-imidazoquinolina e usos relacionados BR112022008039A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962927354P 2019-10-29 2019-10-29
PCT/US2020/056515 WO2021086689A1 (en) 2019-10-29 2020-10-20 4-amino-imidazoquinoline compounds and use thereof

Publications (1)

Publication Number Publication Date
BR112022008039A2 true BR112022008039A2 (pt) 2022-07-12

Family

ID=75715560

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022008039A BR112022008039A2 (pt) 2019-10-29 2020-10-20 Compostos de 4-amino-imidazoquinolina e usos relacionados

Country Status (8)

Country Link
US (1) US20220411421A1 (pt)
EP (1) EP4051270A4 (pt)
JP (1) JP7773011B2 (pt)
KR (1) KR20220091528A (pt)
CN (1) CN114599360A (pt)
AU (1) AU2020372832B2 (pt)
BR (1) BR112022008039A2 (pt)
WO (1) WO2021086689A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023081237A1 (en) * 2021-11-03 2023-05-11 Regents Of The University Of Minnesota Toll-like receptor agonists and antagonists and uses thereof
CN116731015B (zh) * 2023-05-18 2024-09-27 深圳威科森生物医药科技有限公司 咪唑并喹啉化合物及其制备方法、应用和组合物
KR20250019209A (ko) 2023-07-31 2025-02-10 건국대학교 글로컬산학협력단 니트로퓨라존 또는 니트로퓨란토인을 유효성분으로 하는 알레르기 질환 예방 또는 치료용 약학적 조성물
CN119215159A (zh) * 2024-09-24 2024-12-31 深圳市格茵莱生物科技有限公司 树突状细胞多抗原负载免疫治疗方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
UA74852C2 (en) 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
US6677348B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6664265B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
CA2510375A1 (en) 2002-12-20 2004-07-15 3M Innovative Properties Company Aryl / hetaryl substituted imidazoquinolines
US20070259881A1 (en) * 2004-06-18 2007-11-08 Dellaria Joseph F Jr Substituted Imidazo Ring Systems and Methods
EP1789042B1 (en) * 2004-09-02 2012-05-02 3M Innovative Properties Company 1-alkoxy 1h-imidazo ring systems and methods
DK2276486T3 (da) * 2008-03-24 2013-11-25 4Sc Discovery Gmbh Nye substituerede imidazo-quinoliner
EP2471548A1 (de) * 2010-12-28 2012-07-04 Apeiron Biologics AG siRNA gegen Cbl-b und optional IL2 und IL12 zur Verwendung in der Behandlung von Krebs
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
BR112013031039B1 (pt) * 2011-06-03 2020-04-28 3M Innovative Properties Co compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado
WO2014201245A1 (en) * 2013-06-12 2014-12-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tlr-9 agonist with tlr-7 and/or tlr-8 agonist for treating tumors
PT3134402T (pt) * 2014-04-22 2020-07-02 Hoffmann La Roche Compostos de 4-amino-imidazoquinolina
US9884866B2 (en) 2014-09-08 2018-02-06 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
US11464854B2 (en) * 2017-03-23 2022-10-11 Children's Medical Center Corporation Methods and compositions relating to adjuvants
ES2951817T3 (es) 2017-08-22 2023-10-25 Dynavax Tech Corp Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos
WO2019048036A1 (en) * 2017-09-06 2019-03-14 Biontech Ag SUBSTITUTED IMIDAZOQUINOLINES
EP3917926B1 (en) 2019-02-01 2025-10-01 Canwell Biotech Limited Imidazoquinoline amine derivatives, pharmaceutical composition, use thereof
JP7590354B2 (ja) 2019-06-10 2024-11-26 ストロ バイオファーマ インコーポレーテッド 免疫調節物質抗体薬物コンジュゲートおよびその使用

Also Published As

Publication number Publication date
TW202128687A (zh) 2021-08-01
CN114599360A (zh) 2022-06-07
WO2021086689A1 (en) 2021-05-06
KR20220091528A (ko) 2022-06-30
CA3152757A1 (en) 2021-05-06
EP4051270A1 (en) 2022-09-07
AU2020372832B2 (en) 2024-09-26
AU2020372832A1 (en) 2022-05-12
JP2023501163A (ja) 2023-01-18
US20220411421A1 (en) 2022-12-29
JP7773011B2 (ja) 2025-11-19
EP4051270A4 (en) 2024-02-28

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