BR112022014362A2 - Complexo de 7-desacetil-forscolina (7-dafsk) e polivinilpirrolidona (pvp), processo para a preparação de tal complexo, e uma composição farmacêutica útil como um medicamento contendo o dito complexo - Google Patents

Complexo de 7-desacetil-forscolina (7-dafsk) e polivinilpirrolidona (pvp), processo para a preparação de tal complexo, e uma composição farmacêutica útil como um medicamento contendo o dito complexo

Info

Publication number
BR112022014362A2
BR112022014362A2 BR112022014362A BR112022014362A BR112022014362A2 BR 112022014362 A2 BR112022014362 A2 BR 112022014362A2 BR 112022014362 A BR112022014362 A BR 112022014362A BR 112022014362 A BR112022014362 A BR 112022014362A BR 112022014362 A2 BR112022014362 A2 BR 112022014362A2
Authority
BR
Brazil
Prior art keywords
complex
dafsk
pvp
pharmaceutical composition
desacetyl
Prior art date
Application number
BR112022014362A
Other languages
English (en)
Inventor
Andreas Kubin
Original Assignee
Scipharm Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scipharm Sarl filed Critical Scipharm Sarl
Publication of BR112022014362A2 publication Critical patent/BR112022014362A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

COMPLEXO DE 7-DESACETIL-FORSCOLINA (7-DAFSK) E POLIVINILPIRROLIDONA (PVP), PROCESSO PARA A PREPARAÇÃO DE TAL COMPLEXO, E UMA COMPOSIÇÃO FARMACÊUTICA ÚTIL COMO UM MEDICAMENTO CONTENDO O DITO COMPLEXO. A presente invenção se refere a um complexo de 7-desacetil-forscolina (7-DAFSK) e polivinilpirrolidona (PVP). Além disso, a invenção se refere a um processo para a preparação de tal complexo 7-DAFSK-PVP e a uma composição farmacêutica contendo o dito complexo.
BR112022014362A 2020-01-23 2021-01-22 Complexo de 7-desacetil-forscolina (7-dafsk) e polivinilpirrolidona (pvp), processo para a preparação de tal complexo, e uma composição farmacêutica útil como um medicamento contendo o dito complexo BR112022014362A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20153429 2020-01-23
PCT/EP2021/051499 WO2021148633A1 (de) 2020-01-23 2021-01-22 Komplex aus 7-deacetylforskolin und pvp

Publications (1)

Publication Number Publication Date
BR112022014362A2 true BR112022014362A2 (pt) 2022-09-13

Family

ID=69190714

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022014362A BR112022014362A2 (pt) 2020-01-23 2021-01-22 Complexo de 7-desacetil-forscolina (7-dafsk) e polivinilpirrolidona (pvp), processo para a preparação de tal complexo, e uma composição farmacêutica útil como um medicamento contendo o dito complexo

Country Status (18)

Country Link
US (1) US20230346956A1 (pt)
EP (1) EP4093374B1 (pt)
JP (1) JP7700133B2 (pt)
AU (1) AU2021211146B2 (pt)
BR (1) BR112022014362A2 (pt)
CA (1) CA3166464A1 (pt)
DK (1) DK4093374T3 (pt)
ES (1) ES2969594T3 (pt)
FI (1) FI4093374T3 (pt)
HR (1) HRP20240181T1 (pt)
HU (1) HUE065181T2 (pt)
IL (1) IL294848B2 (pt)
LT (1) LT4093374T (pt)
PL (1) PL4093374T3 (pt)
PT (1) PT4093374T (pt)
RS (1) RS65265B1 (pt)
SI (1) SI4093374T1 (pt)
WO (1) WO2021148633A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294205B1 (it) * 1997-07-23 1999-03-24 Farmigea Spa Procedimento per la solubilizzazione in acqua e in veicoli acquosi di sostanze farmacologicamente attive
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
JP2007210988A (ja) * 2006-02-07 2007-08-23 Sabinsa Corp ジテルペンフォルスコリン及びその誘導体で男性ホルモン及び女性ホルモンを生理学的に増大するための組成物
WO2017103840A1 (en) * 2015-12-16 2017-06-22 MOHAMED ABDULLA ANZAR, Cheppattu A water soluble 10% w/w forskolin composition and a method of synthesizing the same
LT3565602T (lt) * 2017-01-09 2021-06-25 SciPharm S.à r.l. Naujas būdas, skirtas vandenyje tirpaus forskolino paruošimui

Also Published As

Publication number Publication date
JP7700133B2 (ja) 2025-06-30
HUE065181T2 (hu) 2024-05-28
ES2969594T3 (es) 2024-05-21
EP4093374A1 (de) 2022-11-30
LT4093374T (lt) 2024-03-12
HRP20240181T1 (hr) 2024-04-26
RS65265B1 (sr) 2024-03-29
IL294848B2 (en) 2026-05-01
WO2021148633A1 (de) 2021-07-29
IL294848A (en) 2022-09-01
AU2021211146B2 (en) 2026-02-12
PL4093374T3 (pl) 2024-04-15
US20230346956A1 (en) 2023-11-02
AU2021211146A1 (en) 2022-09-01
JP2023511432A (ja) 2023-03-17
FI4093374T3 (en) 2024-02-06
EP4093374B1 (de) 2023-11-15
SI4093374T1 (sl) 2024-03-29
DK4093374T3 (da) 2024-02-05
CA3166464A1 (en) 2021-07-29
IL294848B1 (en) 2026-01-01
PT4093374T (pt) 2024-01-23

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