BR112022017583A2 - Hidrogel heterogêneo híbrido, método para fabricação e uso do mesmo como implante de enchimento in situ não degradável - Google Patents

Hidrogel heterogêneo híbrido, método para fabricação e uso do mesmo como implante de enchimento in situ não degradável

Info

Publication number
BR112022017583A2
BR112022017583A2 BR112022017583A BR112022017583A BR112022017583A2 BR 112022017583 A2 BR112022017583 A2 BR 112022017583A2 BR 112022017583 A BR112022017583 A BR 112022017583A BR 112022017583 A BR112022017583 A BR 112022017583A BR 112022017583 A2 BR112022017583 A2 BR 112022017583A2
Authority
BR
Brazil
Prior art keywords
microbeads
microns
degradable
manufacturing
implant
Prior art date
Application number
BR112022017583A
Other languages
English (en)
Inventor
Woerly Stéphane
Original Assignee
Neurobiomat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurobiomat filed Critical Neurobiomat
Publication of BR112022017583A2 publication Critical patent/BR112022017583A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Prostheses (AREA)

Abstract

HIDROGEL HETEROGÊNEO HÍBRIDO, MÉTODO PARA FABRICAÇÃO E USO DO MESMO COMO IMPLANTE DE. ENCHIMENTO IN SITU NÃO DEGRADÁVEL. A presente invenção refere-se a um implante de enchimento compreendendo uma estrutura fabricada de hidrogel heterogêneo híbrido formado por um copolímero compreendendo: um monômero dendrímero funcionalizado por um radical etileno, um composto acrilamida escolhido de uma metacrilamida N-substituída e uma acrilamida N-substituída, um agente de reticulação e um material copolimerizável bioativo. A estrutura é formada por micropérolas tendo um diâmetro compreendido entre 1,5 mícron e 10 micra e contém principalmente em peso um composto acri-lamida. As micropérolas são montadas para formar agregados contendo entre 5 e 50 micropérolas. Os agregados são ligados através de pontos de reticulação para definirem um arranjo poroso atravessante definindo caminhos de percolação tridimensionais. O arranjo poroso atravessante é formado por poros a maioria do volume de poros dos quais tem um diâmetro compreendido entre 10 e 30 micra. A estrutura tem uma natureza viscoelástica com um módulo de elasticidade compreendido entre 1 e 200 kPa.
BR112022017583A 2020-03-17 2021-03-17 Hidrogel heterogêneo híbrido, método para fabricação e uso do mesmo como implante de enchimento in situ não degradável BR112022017583A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2002619A FR3108260B1 (fr) 2020-03-17 2020-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ
PCT/EP2021/056753 WO2021185881A1 (fr) 2020-03-17 2021-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ

Publications (1)

Publication Number Publication Date
BR112022017583A2 true BR112022017583A2 (pt) 2022-10-18

Family

ID=71452405

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022017583A BR112022017583A2 (pt) 2020-03-17 2021-03-17 Hidrogel heterogêneo híbrido, método para fabricação e uso do mesmo como implante de enchimento in situ não degradável

Country Status (12)

Country Link
US (1) US12599703B2 (pt)
EP (1) EP4121133B1 (pt)
JP (1) JP2023518227A (pt)
KR (1) KR20220154749A (pt)
CN (1) CN115297903B (pt)
AU (1) AU2021237753A1 (pt)
BR (1) BR112022017583A2 (pt)
CA (1) CA3167699A1 (pt)
FR (1) FR3108260B1 (pt)
IL (1) IL296328B2 (pt)
MX (1) MX2022011096A (pt)
WO (1) WO2021185881A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230386697A1 (en) * 2020-10-13 2023-11-30 President And Fellows Of Harvard College Viscoelastic conductive hydrogel
WO2022251643A1 (en) * 2021-05-27 2022-12-01 The Regents Of The University Of California Superporous gel matrix for encapsulation of cells
CN114103125B (zh) * 2021-09-30 2022-06-28 哈尔滨工业大学（威海） 一种高导热微型器件的制备方法

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US5863551A (en) * 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
WO2001005578A1 (en) * 1999-07-16 2001-01-25 Wesley-Jessen Corporation Thermoformable ophthalmic lens
US7163545B2 (en) 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
JP2006503080A (ja) * 2002-10-11 2006-01-26 ノボセル インコーポレイテッド 疾患治療用のカプセルで包んだ生物材料の移植
US7569222B2 (en) * 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
ATE464025T1 (de) * 2004-08-13 2010-04-15 Setagon Inc Herstellungsverfahren für medizinprodukte mit nanoporösen schichten
US8377463B2 (en) 2006-04-25 2013-02-19 Children's Medical Center Corporation Methods and compositions for the treatment of open and closed wound spinal cord injuries
RU2394593C2 (ru) 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции
FR2942080B1 (fr) 2009-02-09 2011-04-01 Vehicules Electr Soc D Procede de gestion thermique d'une batterie electrique
FR2942408B1 (fr) * 2009-02-24 2012-01-27 Stephane Woerly Hydrogel heterogene hybride et son utilisation therapeutique
KR101091028B1 (ko) 2009-07-02 2011-12-09 아주대학교산학협력단 체내 주입형 하이드로젤 및 이의 생의학적 용도
US8877498B2 (en) 2010-12-01 2014-11-04 Drexel University Porous polymer scaffolds for neural tissue engineering and methods of producing the same
TW201313263A (zh) 2011-07-13 2013-04-01 Invivo Therapeutics Corp 聚乳酸-聚乙醇酸(plga)-b-離胺酸及plga與pll(聚e-cbz-l離胺酸)嵌段共聚物合成方法
JP6319847B2 (ja) 2011-12-06 2018-05-09 バイオアークティック アーベー 軸索再生を促進するための脊髄装置および方法
FR2993566B1 (fr) 2012-07-19 2015-05-15 Univ Claude Bernard Lyon Hydrogel de chitosane pour la reparation du tissu nerveux
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CN105412935B (zh) * 2015-02-04 2019-02-19 四川大学 一种基于n-(2-羟丙基)甲基丙烯酰胺聚合物的纳米粒及其制备方法
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MX2024007071A (es) * 2021-12-09 2024-08-26 Likarda Llc Rellenos de tejido suave a base de micropartículas de hidrogel.

Also Published As

Publication number Publication date
IL296328A (en) 2022-11-01
EP4121133A1 (fr) 2023-01-25
US20230166005A1 (en) 2023-06-01
CN115297903A (zh) 2022-11-04
WO2021185881A1 (fr) 2021-09-23
CN115297903B (zh) 2024-03-12
AU2021237753A1 (en) 2022-10-20
FR3108260A1 (fr) 2021-09-24
EP4121133C0 (fr) 2023-08-16
US12599703B2 (en) 2026-04-14
IL296328B1 (en) 2025-11-01
KR20220154749A (ko) 2022-11-22
FR3108260B1 (fr) 2024-01-05
JP2023518227A (ja) 2023-04-28
IL296328B2 (en) 2026-03-01
EP4121133B1 (fr) 2023-08-16
CA3167699A1 (en) 2021-09-23
MX2022011096A (es) 2022-11-10

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