BRPI0409762A - processo de reticulação de pelo menos um polìmero, processo de preparação de um hidrogel monofásico injetável, polìmero reticulado e hidrogel monofásico injetável - Google Patents

processo de reticulação de pelo menos um polìmero, processo de preparação de um hidrogel monofásico injetável, polìmero reticulado e hidrogel monofásico injetável

Info

Publication number
BRPI0409762A
BRPI0409762A BRPI0409762-9A BRPI0409762A BRPI0409762A BR PI0409762 A BRPI0409762 A BR PI0409762A BR PI0409762 A BRPI0409762 A BR PI0409762A BR PI0409762 A BRPI0409762 A BR PI0409762A
Authority
BR
Brazil
Prior art keywords
cross
polymer
injectable
single phase
phase hydrogel
Prior art date
Application number
BRPI0409762-9A
Other languages
English (en)
Inventor
Pierre Lebreton
Original Assignee
Corneal Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33186443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0409762(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corneal Ind filed Critical Corneal Ind
Publication of BRPI0409762A publication Critical patent/BRPI0409762A/pt
Publication of BRPI0409762B1 publication Critical patent/BRPI0409762B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

"PROCESSO DE RETICULAçãO DE PELO MENOS UM POLìMERO, PROCESSO DE PREPARAçãO DE UM HIDROGEL MONOFáSICO INJETáVEL, POLìMERO RETICULADO E HIDROGEL MONOFáSICO INJETáVEL". A presente invenção tem por objeto: - um processo de reticulação de pelo menos um polímero, escolhido entre os polissacarídeos e seus derivados, realizado em um solvente aquoso por ação de uma quantidade eficaz e não excessiva de pelo menos um agente de reticulação, caracterizado pelo fato de ser realizado com uma mistura que contém pelo menos um polímero de massa molecular baixa e pelo menos um polímero de massa molecular elevada; -um processo de preparação de um hidrogel monofásico injetável de pelo menos um polímero reticulado escolhido entre os polissacarídeos e seus derivados; -os polímeros reticulados e hidrogéis monofásicos injetáveis, suscetíveis de serem obtidos respectivamente por cada um dos referidos processos.
BRPI0409762-9A 2003-04-10 2004-04-08 Processo para preparar um polímero reticulado e processo para preparar um hidrogel monofásico injetável BRPI0409762B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0304444 2003-04-10
FR0304444A FR2861734B1 (fr) 2003-04-10 2003-04-10 Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
PCT/FR2004/000870 WO2004092222A2 (fr) 2003-04-10 2004-04-08 Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus;

Publications (2)

Publication Number Publication Date
BRPI0409762A true BRPI0409762A (pt) 2006-05-09
BRPI0409762B1 BRPI0409762B1 (pt) 2021-10-13

Family

ID=33186443

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409762-9A BRPI0409762B1 (pt) 2003-04-10 2004-04-08 Processo para preparar um polímero reticulado e processo para preparar um hidrogel monofásico injetável

Country Status (8)

Country Link
US (9) US7741476B2 (pt)
EP (3) EP2289945B1 (pt)
JP (1) JP4827727B2 (pt)
BR (1) BRPI0409762B1 (pt)
CA (1) CA2521961C (pt)
ES (1) ES2536564T3 (pt)
FR (1) FR2861734B1 (pt)
WO (1) WO2004092222A2 (pt)

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US8338388B2 (en) 2012-12-25
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US20140011990A1 (en) 2014-01-09
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US20160317571A1 (en) 2016-11-03
FR2861734A1 (fr) 2005-05-06
US8563532B2 (en) 2013-10-22
US20120295870A1 (en) 2012-11-22
US10653716B2 (en) 2020-05-19
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US20190022130A1 (en) 2019-01-24
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US20200246375A1 (en) 2020-08-06
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US20210322460A1 (en) 2021-10-21
CA2521961C (en) 2013-07-23
US10080767B2 (en) 2018-09-25
US20100226988A1 (en) 2010-09-09
US9062130B2 (en) 2015-06-23
CA2521961A1 (en) 2004-10-28
BRPI0409762B1 (pt) 2021-10-13
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