BR9203883A - Processo para preparacao de 4-haloquinazolinas e de 4-cloroquinazolinas - Google Patents
Processo para preparacao de 4-haloquinazolinas e de 4-cloroquinazolinasInfo
- Publication number
- BR9203883A BR9203883A BR929203883A BR9203883A BR9203883A BR 9203883 A BR9203883 A BR 9203883A BR 929203883 A BR929203883 A BR 929203883A BR 9203883 A BR9203883 A BR 9203883A BR 9203883 A BR9203883 A BR 9203883A
- Authority
- BR
- Brazil
- Prior art keywords
- halochinazolins
- chlorochinazolins
- preparation
- haloquinazolines
- hydroxyquinazolines
- Prior art date
Links
- -1 carbonyl halide Chemical class 0.000 abstract 2
- QMNUDYFKZYBWQX-UHFFFAOYSA-N 1H-quinazolin-4-one Chemical class C1=CC=C2C(=O)N=CNC2=C1 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/772,523 US5214144A (en) | 1991-10-07 | 1991-10-07 | Process for the preparation of 4-haloquinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9203883A true BR9203883A (pt) | 1993-04-27 |
Family
ID=25095358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR929203883A BR9203883A (pt) | 1991-10-07 | 1992-10-06 | Processo para preparacao de 4-haloquinazolinas e de 4-cloroquinazolinas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5214144A (pt) |
| EP (1) | EP0537600B1 (pt) |
| JP (1) | JPH05222004A (pt) |
| KR (1) | KR100218608B1 (pt) |
| AT (1) | ATE155461T1 (pt) |
| AU (1) | AU648933B2 (pt) |
| BR (1) | BR9203883A (pt) |
| DE (1) | DE69220875T2 (pt) |
| ES (1) | ES2104787T3 (pt) |
| HU (1) | HU213830B (pt) |
| IL (1) | IL103362A (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| AU727200B2 (en) * | 1996-03-15 | 2000-12-07 | Dow Agrosciences Llc | Halogenation catalyst |
| US6706721B1 (en) * | 1998-04-29 | 2004-03-16 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US7087613B2 (en) * | 1999-11-11 | 2006-08-08 | Osi Pharmaceuticals, Inc. | Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
| CN103265497B (zh) * | 2013-05-16 | 2014-11-26 | 苏州明锐医药科技有限公司 | 一种替尼类抗肿瘤药合成所需中间体4-氯-6-氨基-7-羟基喹唑啉及其制备方法 |
| CN106496146A (zh) * | 2016-10-18 | 2017-03-15 | 江西师范大学 | 一种二氢喹唑啉酮和喹唑啉酮衍生物的磺酸类离子液体催化调控合成方法 |
| CN108299315A (zh) * | 2018-03-01 | 2018-07-20 | 杨子辉 | 一种杀螨剂喹螨醚的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US450870A (en) * | 1891-04-21 | Bag-fastening | ||
| US1880447A (en) * | 1932-10-04 | Max haedtmann | ||
| GB1088102A (en) * | 1964-01-10 | 1967-10-25 | Wellcome Found | Halogen substituted pyrido-pyrimidines |
| US3998951A (en) * | 1974-03-13 | 1976-12-21 | Fmc Corporation | Substituted 2-arylquinazolines as fungicides |
| US4510307A (en) * | 1980-08-20 | 1985-04-09 | Asahi Kasei Kogyo Kabushiki Kaisha | 6-Quinazolinesulfonyl derivatives and process for preparation thereof |
| US4672116A (en) * | 1985-12-20 | 1987-06-09 | Ortho Pharmaceutical Corporation | Substituted 5,6-dialkoxyquinazoline derivatives |
| IL89027A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them |
-
1991
- 1991-10-07 US US07/772,523 patent/US5214144A/en not_active Expired - Lifetime
-
1992
- 1992-10-05 IL IL10336292A patent/IL103362A/en not_active IP Right Cessation
- 1992-10-06 HU HU9203164A patent/HU213830B/hu unknown
- 1992-10-06 KR KR1019920018256A patent/KR100218608B1/ko not_active Expired - Lifetime
- 1992-10-06 EP EP92117058A patent/EP0537600B1/en not_active Expired - Lifetime
- 1992-10-06 ES ES92117058T patent/ES2104787T3/es not_active Expired - Lifetime
- 1992-10-06 BR BR929203883A patent/BR9203883A/pt not_active IP Right Cessation
- 1992-10-06 AU AU26239/92A patent/AU648933B2/en not_active Ceased
- 1992-10-06 JP JP4290890A patent/JPH05222004A/ja active Pending
- 1992-10-06 AT AT92117058T patent/ATE155461T1/de active
- 1992-10-06 DE DE69220875T patent/DE69220875T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69220875D1 (de) | 1997-08-21 |
| ATE155461T1 (de) | 1997-08-15 |
| AU2623992A (en) | 1993-04-08 |
| EP0537600B1 (en) | 1997-07-16 |
| HU213830B (en) | 1997-10-28 |
| KR930007916A (ko) | 1993-05-20 |
| JPH05222004A (ja) | 1993-08-31 |
| IL103362A0 (en) | 1993-03-15 |
| US5214144A (en) | 1993-05-25 |
| KR100218608B1 (ko) | 1999-09-01 |
| IL103362A (en) | 1996-09-12 |
| DE69220875T2 (de) | 1997-11-20 |
| HU9203164D0 (en) | 1992-12-28 |
| ES2104787T3 (es) | 1997-10-16 |
| HUT62868A (en) | 1993-06-28 |
| EP0537600A1 (en) | 1993-04-21 |
| AU648933B2 (en) | 1994-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EE | Request for examination | ||
| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| FF | Decision: intention to grant | ||
| FG9A | Patent or certificate of addition granted | ||
| PC | Transfer |
Free format text: DOW ELANCO LLC (US) |
|
| TC | Change of name | ||
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 06/10/2012 |