BR9206403A - Aril-poliaminas sintéticas como antagonistas de neurotransmissores aminoácidos excitadores - Google Patents
Aril-poliaminas sintéticas como antagonistas de neurotransmissores aminoácidos excitadoresInfo
- Publication number
- BR9206403A BR9206403A BR9206403A BR9206403A BR9206403A BR 9206403 A BR9206403 A BR 9206403A BR 9206403 A BR9206403 A BR 9206403A BR 9206403 A BR9206403 A BR 9206403A BR 9206403 A BR9206403 A BR 9206403A
- Authority
- BR
- Brazil
- Prior art keywords
- neurotransmitter
- polyamines
- antagonists
- amino acids
- excitatory amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74901491A | 1991-08-23 | 1991-08-23 | |
| PCT/US1992/006482 WO1993004036A1 (en) | 1991-08-23 | 1992-08-10 | Synthetic aryl polyamines as excitatory amino acid neurotransmitter antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9206403A true BR9206403A (pt) | 1994-12-27 |
Family
ID=25011863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9206403A BR9206403A (pt) | 1991-08-23 | 1992-08-10 | Aril-poliaminas sintéticas como antagonistas de neurotransmissores aminoácidos excitadores |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0641312A1 (pt) |
| JP (1) | JPH06505996A (pt) |
| CN (1) | CN1069969A (pt) |
| AU (1) | AU2426392A (pt) |
| BR (1) | BR9206403A (pt) |
| CA (1) | CA2114798A1 (pt) |
| CZ (1) | CZ39994A3 (pt) |
| FI (1) | FI940833L (pt) |
| HU (1) | HU9400503D0 (pt) |
| IL (1) | IL102835A0 (pt) |
| MX (1) | MX9204866A (pt) |
| PT (1) | PT100801A (pt) |
| WO (1) | WO1993004036A1 (pt) |
| ZA (1) | ZA926314B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6211245B1 (en) | 1993-02-08 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| AU710575B2 (en) * | 1994-02-08 | 1999-09-23 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US20010004460A1 (en) * | 1995-06-08 | 2001-06-21 | Carla Rasmussen Klittich | Process for the preparation of rice seed for sowing |
| AU2003231670B2 (en) * | 1997-10-27 | 2006-06-08 | Slil Biomedical Corporation | Methods for modulating macrophage proliferation using polyamine analogs |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
| MXPA01011008A (es) | 1999-04-30 | 2003-06-30 | Slil Biomedical Corp | Conjugados analogos de poliamina y conjugados de quinona novedosos como terapia para canceres y enfermedades de la prostata. |
| WO2003033455A1 (en) | 2001-10-16 | 2003-04-24 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
| JP2007505044A (ja) * | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| CN103073448B (zh) * | 2012-12-29 | 2015-11-18 | 河南大学 | 含芳环结构的多胺衍生物及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037846A (en) * | 1990-01-02 | 1991-08-06 | Pfizer Inc. | Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters |
-
1992
- 1992-08-10 HU HU9400503A patent/HU9400503D0/hu unknown
- 1992-08-10 BR BR9206403A patent/BR9206403A/pt not_active Application Discontinuation
- 1992-08-10 FI FI940833A patent/FI940833L/fi not_active Application Discontinuation
- 1992-08-10 CZ CS94399A patent/CZ39994A3/cs unknown
- 1992-08-10 AU AU24263/92A patent/AU2426392A/en not_active Abandoned
- 1992-08-10 WO PCT/US1992/006482 patent/WO1993004036A1/en not_active Ceased
- 1992-08-10 EP EP92916921A patent/EP0641312A1/en not_active Withdrawn
- 1992-08-10 CA CA002114798A patent/CA2114798A1/en not_active Abandoned
- 1992-08-10 JP JP5504331A patent/JPH06505996A/ja active Pending
- 1992-08-17 IL IL102835A patent/IL102835A0/xx unknown
- 1992-08-21 PT PT100801A patent/PT100801A/pt not_active Application Discontinuation
- 1992-08-21 MX MX9204866A patent/MX9204866A/es unknown
- 1992-08-21 ZA ZA926314A patent/ZA926314B/xx unknown
- 1992-08-22 CN CN92109681A patent/CN1069969A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI940833A0 (fi) | 1994-02-22 |
| PT100801A (pt) | 1993-09-30 |
| HU9400503D0 (en) | 1994-05-30 |
| MX9204866A (es) | 1993-04-01 |
| AU2426392A (en) | 1993-03-16 |
| IL102835A0 (en) | 1993-01-31 |
| CA2114798A1 (en) | 1993-03-04 |
| WO1993004036A1 (en) | 1993-03-04 |
| ZA926314B (en) | 1994-02-21 |
| CZ39994A3 (en) | 1994-11-16 |
| JPH06505996A (ja) | 1994-07-07 |
| FI940833A7 (fi) | 1994-02-22 |
| CN1069969A (zh) | 1993-03-17 |
| FI940833L (fi) | 1994-02-22 |
| EP0641312A1 (en) | 1995-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EE | Request for examination | ||
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |