BR9206623A - Uréias cíclicas e análogas úteis como inibidoras da protease retroviral - Google Patents
Uréias cíclicas e análogas úteis como inibidoras da protease retroviralInfo
- Publication number
- BR9206623A BR9206623A BR9206623A BR9206623A BR9206623A BR 9206623 A BR9206623 A BR 9206623A BR 9206623 A BR9206623 A BR 9206623A BR 9206623 A BR9206623 A BR 9206623A BR 9206623 A BR9206623 A BR 9206623A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclic
- similar
- protease inhibitors
- retroviral protease
- ureas useful
- Prior art date
Links
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- 235000013877 carbamide Nutrition 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/04—Seven-membered rings not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77649191A | 1991-10-11 | 1991-10-11 | |
| US88394492A | 1992-05-15 | 1992-05-15 | |
| US95327292A | 1992-09-29 | 1992-09-29 | |
| PCT/US1992/008749 WO1993007128A1 (en) | 1991-10-11 | 1992-10-13 | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9206623A true BR9206623A (pt) | 1995-05-02 |
Family
ID=27419722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9206623A BR9206623A (pt) | 1991-10-11 | 1992-10-13 | Uréias cíclicas e análogas úteis como inibidoras da protease retroviral |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP1153921A3 (pt) |
| JP (1) | JP3208140B2 (pt) |
| KR (1) | KR100268694B1 (pt) |
| AT (2) | ATE156123T1 (pt) |
| AU (2) | AU2871592A (pt) |
| BR (1) | BR9206623A (pt) |
| CA (1) | CA2120925A1 (pt) |
| CZ (1) | CZ284872B6 (pt) |
| DE (2) | DE69221309T2 (pt) |
| DK (1) | DK0607334T3 (pt) |
| ES (1) | ES2104946T3 (pt) |
| FI (1) | FI941649A7 (pt) |
| GR (1) | GR3025005T3 (pt) |
| HU (1) | HU221816B1 (pt) |
| NO (1) | NO306720B1 (pt) |
| RU (1) | RU2131420C1 (pt) |
| SK (1) | SK280882B6 (pt) |
| WO (1) | WO1993007128A1 (pt) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| USRE37781E1 (en) | 1991-10-11 | 2002-07-02 | Dupont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| ES2123065T3 (es) | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| AU703962B2 (en) * | 1993-02-26 | 1999-04-01 | Du Pont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives |
| US5637780A (en) | 1993-03-30 | 1997-06-10 | The Dupont Merck Pharmaceutical Company | Method for preparing alkylating agents and their use for alkylating cyclic ureas |
| EP0708760A1 (en) * | 1993-07-14 | 1996-05-01 | Novartis AG | Cyclic hydrazine compounds |
| US5616578A (en) * | 1993-08-26 | 1997-04-01 | The Dupont Merck Pharmaceutical Company | Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor |
| IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| US5559158A (en) * | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| US5559110A (en) * | 1994-03-09 | 1996-09-24 | The Dupont Merck Pharmaceutical Company | Pharmaceutical formulations of cyclic urea type compounds |
| US5508400A (en) * | 1994-04-20 | 1996-04-16 | The Du Pont Merck Pharmaceutical Company | Preparation of cyclic urea compounds |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| DE4422911A1 (de) | 1994-06-30 | 1996-01-04 | Hoechst Ag | Phosphinsäure-Derivate, deren Herstellung sowie deren Verwendung |
| US5466797A (en) * | 1994-06-30 | 1995-11-14 | The Du Pont Merck Pharmaceutical Company | Intermediates for the preparation of cyclic urea |
| US5530124A (en) * | 1994-06-30 | 1996-06-25 | The Dupont Merck Pharmaceutical Company | Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors |
| US5705524A (en) * | 1994-11-04 | 1998-01-06 | Gilead Sciences, Inc. | Thiepane compounds |
| EP0789695A2 (en) * | 1994-11-04 | 1997-08-20 | Gilead Sciences, Inc. | Thiepane compounds inhibiting and detecting hiv protease |
| US6034118A (en) * | 1994-11-04 | 2000-03-07 | Gilead Sciences, Inc. | Thiepane compounds |
| EP0815108A1 (en) * | 1995-03-17 | 1998-01-07 | The Du Pont Merck Pharmaceutical Company | Cyclic urea hiv protease inhibitors |
| US5683999A (en) * | 1995-03-17 | 1997-11-04 | The Dupont Merck Pharmaceutical Company | Cyclic urea HIV protease inhibitors |
| US5532356A (en) * | 1995-06-06 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N,N'-disubstituted cyclic ureas |
| US5532357A (en) * | 1995-06-07 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| WO1997008150A1 (en) * | 1995-08-22 | 1997-03-06 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| EA001485B1 (ru) * | 1996-03-29 | 2001-04-23 | Пфайзер Инк. | Производные бензил(иден)-лактамов, их получение и применение в качестве селективных (ант)агонистов рецепторов 5-htи/или 5-ht |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| CA2270963A1 (en) * | 1996-11-08 | 1998-05-14 | The Dupont Merck Pharmaceutical Company | (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor |
| ZA979868B (en) | 1996-11-08 | 1999-05-03 | Du Pont Merck Pharma | A 1-(3-aminondazol-5-yl)-3-buty-cyclic urea useful as a HIV protease inhibitor |
| ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
| US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| AU6896298A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| WO1998046628A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| NZ500354A (en) | 1997-04-14 | 2001-11-30 | Cor Therapeutics Inc | Cyclic diaza compounds as selective factor Xa inhibitors for treating thrombotic related disorders |
| US6369063B1 (en) | 1997-04-14 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| KR100348561B1 (ko) * | 1997-08-12 | 2002-09-18 | 주식회사 엘지씨아이 | Lb71350과 dmp450을 함유하는 조성물 |
| KR19990016003A (ko) * | 1997-08-12 | 1999-03-05 | 성재갑 | 치토크롬 저해제 조성물 |
| US6313110B1 (en) | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
| DE19962923A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Benzoylcyclohexandione |
| TR201809435T4 (tr) | 2000-01-19 | 2018-07-23 | Abbvie Inc | Geliştirilmiş farmasötik formülasyonlar. |
| FR2810039B1 (fr) | 2000-06-13 | 2007-05-25 | Centre Nat Rech Scient | Composes urees cycliques et leur procede de preparation |
| UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| AU2003252259A1 (en) * | 2002-07-26 | 2004-02-16 | Nihon Nohyaku Co., Ltd. | Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof |
| JP2004107323A (ja) * | 2002-07-26 | 2004-04-08 | Nippon Nohyaku Co Ltd | 新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法 |
| US7834043B2 (en) | 2003-12-11 | 2010-11-16 | Abbott Laboratories | HIV protease inhibiting compounds |
| US7777030B2 (en) | 2005-12-29 | 2010-08-17 | Centre National de la Recherge Scientifique (CNRS) | Compositions and methods for the treatment and prevention of disease |
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| CN101631568B (zh) | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US9095620B2 (en) | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010010157A2 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| JP2012530069A (ja) | 2009-06-12 | 2012-11-29 | ネクター セラピューティックス | プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体 |
| US8569245B2 (en) * | 2009-06-26 | 2013-10-29 | University Of Florida Research Foundation, Inc. | Protease inhibitors, compositions and methods of use |
| EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| PT2692346E (pt) * | 2010-10-13 | 2016-03-22 | Abbvie Bahamas Ltd | Um derivado de 1-fenil-2,5-dibenzimidazol-5-il-pirrolidina antiviral |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| WO2024052685A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA735593B (en) * | 1972-08-24 | 1974-07-31 | Ciba Geigy Ag | Piperidine derivatives and process for their manufacture |
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US4652552A (en) | 1984-09-10 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Tetrapeptide methyl ketone inhibitors of viral proteases |
| US4644055A (en) | 1984-12-17 | 1987-02-17 | E. I. Du Pont De Nemours And Company | Method for preparing specific inhibitors of virus-specified proteases |
| US4837204A (en) | 1985-01-23 | 1989-06-06 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols |
| JPH072736B2 (ja) * | 1985-08-27 | 1995-01-18 | 日本バイエルアグロケム株式会社 | ニトロメチレン誘導体、その製法及び殺虫剤 |
| CA1283101C (en) * | 1986-05-06 | 1991-04-16 | Teruyuki Nagata | Process for producing cyclic ureas |
| US4900820A (en) * | 1986-06-12 | 1990-02-13 | Mitsui Toatsu Chemicals, Inc. | Process for producing cyclic ureas |
| FR2600252A1 (fr) | 1986-06-19 | 1987-12-24 | Inst Nat Sante Rech Med | Medicament et composition medicamenteuse pour le traitement de maladies infectieuses dues aux virus, ainsi que pour le traitement des tumeurs |
| GB8806449D0 (en) * | 1988-03-18 | 1988-04-20 | Janssen Pharmaceutica Nv | Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones |
| IL90218A0 (en) | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
| EP0374097A3 (de) | 1988-12-15 | 1991-06-12 | Ciba-Geigy Ag | Verwendung von Peptidisosteren als retrovirale Proteasehemmer |
| IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them |
| US5049548A (en) | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
| CA2010531A1 (en) | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
| CA2032259A1 (en) | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
| CA2026832A1 (fr) | 1990-10-03 | 1992-04-04 | Nouredine Haouas | Systeme demontable d'attache rapide pour objets tridimensionnels entre eux |
| US5206244A (en) * | 1990-10-18 | 1993-04-27 | E. R. Squibb & Sons, Inc. | Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines |
-
1992
- 1992-10-13 DE DE69221309T patent/DE69221309T2/de not_active Expired - Fee Related
- 1992-10-13 HU HU9401020A patent/HU221816B1/hu not_active IP Right Cessation
- 1992-10-13 SK SK407-94A patent/SK280882B6/sk unknown
- 1992-10-13 EP EP01119426A patent/EP1153921A3/en not_active Withdrawn
- 1992-10-13 BR BR9206623A patent/BR9206623A/pt not_active Application Discontinuation
- 1992-10-13 CZ CZ94814A patent/CZ284872B6/cs not_active IP Right Cessation
- 1992-10-13 WO PCT/US1992/008749 patent/WO1993007128A1/en not_active Ceased
- 1992-10-13 JP JP50724493A patent/JP3208140B2/ja not_active Expired - Fee Related
- 1992-10-13 DK DK92922262.8T patent/DK0607334T3/da active
- 1992-10-13 EP EP92922262A patent/EP0607334B1/en not_active Expired - Lifetime
- 1992-10-13 AT AT92922262T patent/ATE156123T1/de not_active IP Right Cessation
- 1992-10-13 DE DE69232568T patent/DE69232568T2/de not_active Expired - Fee Related
- 1992-10-13 CA CA002120925A patent/CA2120925A1/en not_active Abandoned
- 1992-10-13 AU AU28715/92A patent/AU2871592A/en not_active Abandoned
- 1992-10-13 EP EP96118182A patent/EP0765873B1/en not_active Expired - Lifetime
- 1992-10-13 RU RU94031126/04A patent/RU2131420C1/ru not_active IP Right Cessation
- 1992-10-13 AT AT96118182T patent/ATE216371T1/de not_active IP Right Cessation
- 1992-10-13 FI FI941649A patent/FI941649A7/fi unknown
- 1992-10-13 ES ES92922262T patent/ES2104946T3/es not_active Expired - Lifetime
- 1992-10-13 KR KR1019940701169A patent/KR100268694B1/ko not_active Expired - Fee Related
-
1994
- 1994-04-08 NO NO941278A patent/NO306720B1/no not_active IP Right Cessation
- 1994-05-02 AU AU61808/94A patent/AU694417B2/en not_active Ceased
-
1997
- 1997-10-09 GR GR970402648T patent/GR3025005T3/el unknown
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