ES2104946T3 - Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica. - Google Patents

Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica.

Info

Publication number
ES2104946T3
ES2104946T3 ES92922262T ES92922262T ES2104946T3 ES 2104946 T3 ES2104946 T3 ES 2104946T3 ES 92922262 T ES92922262 T ES 92922262T ES 92922262 T ES92922262 T ES 92922262T ES 2104946 T3 ES2104946 T3 ES 2104946T3
Authority
ES
Spain
Prior art keywords
protease inhibitors
retroviric
cyclic ureas
similar useful
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922262T
Other languages
English (en)
Inventor
Patrick Yuk-Sun Lam
Charles Joseph Eyermann
Carl Nicholas Hodge
Prabhakar Kondaji Jadhav
George Vincent Delucca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2104946T3 publication Critical patent/ES2104946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/04—Seven-membered rings not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA INVENCION DESCRIBE CARBONILOS CICLICOS SUSTITUIDOS Y SUS DERIVADOS UTILES COMO INHIBIDORES DE PROTEASA RETROVIRAL, PARA COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN TALES COMPUESTOS, Y PARA LOS METODOS DE USO DE LOS COMPUESTOS PARA TRATAR LA INFECCION VIRAL.
ES92922262T 1991-10-11 1992-10-13 Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica. Expired - Lifetime ES2104946T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77649191A 1991-10-11 1991-10-11
US88394492A 1992-05-15 1992-05-15
US95327292A 1992-09-29 1992-09-29

Publications (1)

Publication Number Publication Date
ES2104946T3 true ES2104946T3 (es) 1997-10-16

Family

ID=27419722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922262T Expired - Lifetime ES2104946T3 (es) 1991-10-11 1992-10-13 Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica.

Country Status (19)

Country Link
EP (3) EP1153921A3 (es)
JP (1) JP3208140B2 (es)
KR (1) KR100268694B1 (es)
AT (2) ATE216371T1 (es)
AU (2) AU2871592A (es)
BR (1) BR9206623A (es)
CA (1) CA2120925A1 (es)
CZ (1) CZ284872B6 (es)
DE (2) DE69232568T2 (es)
DK (1) DK0607334T3 (es)
ES (1) ES2104946T3 (es)
FI (1) FI941649L (es)
GR (1) GR3025005T3 (es)
HK (1) HK1002257A1 (es)
HU (1) HU221816B1 (es)
NO (1) NO306720B1 (es)
RU (1) RU2131420C1 (es)
SK (1) SK280882B6 (es)
WO (1) WO1993007128A1 (es)

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USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
DE122007000045I2 (de) 1992-08-25 2011-07-21 Gd Searle Llc Gd Searle Llc Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen.
AU703962B2 (en) * 1993-02-26 1999-04-01 Du Pont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives
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US5616578A (en) * 1993-08-26 1997-04-01 The Dupont Merck Pharmaceutical Company Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor
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Also Published As

Publication number Publication date
EP0607334A1 (en) 1994-07-27
DE69221309T2 (de) 1997-12-11
SK40794A3 (en) 1994-12-07
FI941649A0 (fi) 1994-04-08
AU694417B2 (en) 1998-07-23
CA2120925A1 (en) 1993-04-15
EP0765873A1 (en) 1997-04-02
KR100268694B1 (ko) 2000-10-16
SK280882B6 (sk) 2000-08-14
ATE156123T1 (de) 1997-08-15
JP3208140B2 (ja) 2001-09-10
DE69232568T2 (de) 2002-12-19
CZ284872B6 (cs) 1999-03-17
HU9401020D0 (en) 1994-07-28
NO941278D0 (no) 1994-04-08
EP1153921A2 (en) 2001-11-14
GR3025005T3 (en) 1998-01-30
DE69221309D1 (de) 1997-09-04
HU221816B1 (hu) 2003-01-28
NO306720B1 (no) 1999-12-13
DE69232568D1 (de) 2002-05-23
WO1993007128A1 (en) 1993-04-15
RU2131420C1 (ru) 1999-06-10
EP0607334B1 (en) 1997-07-30
DK0607334T3 (da) 1998-02-16
ATE216371T1 (de) 2002-05-15
HUT67285A (en) 1995-03-28
JPH07500324A (ja) 1995-01-12
BR9206623A (pt) 1995-05-02
FI941649A7 (fi) 1994-05-31
NO941278L (no) 1994-06-10
AU2871592A (en) 1993-05-03
FI941649L (fi) 1994-05-31
AU6180894A (en) 1994-07-07
EP0765873B1 (en) 2002-04-17
EP1153921A3 (en) 2001-11-21
CZ81494A3 (en) 1994-11-16
HK1002257A1 (en) 1998-08-07

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