BR9408638A - Geração de insulina humana - Google Patents

Geração de insulina humana

Info

Publication number
BR9408638A
BR9408638A BR9408638-9A BR9408638A BR9408638A BR 9408638 A BR9408638 A BR 9408638A BR 9408638 A BR9408638 A BR 9408638A BR 9408638 A BR9408638 A BR 9408638A
Authority
BR
Brazil
Prior art keywords
human insulin
folded
polypeptide
insulin generation
new
Prior art date
Application number
BR9408638-9A
Other languages
English (en)
Inventor
Jacob Hartman
Simona Mendelovitz
Marian Gorecki
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22243290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9408638(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of BR9408638A publication Critical patent/BR9408638A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

"GERAçãO DE INSULINA HUMANA". Um processo melhorado e eficaz para a produção de insulina humana recombinante por duplicação de um polipeptídeo híbrido de proinsulina é provido.
BR9408638-9A 1994-12-29 1994-12-29 Geração de insulina humana BR9408638A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/013268 WO1996020724A1 (en) 1994-12-29 1994-12-29 Generation of human insulin

Publications (1)

Publication Number Publication Date
BR9408638A true BR9408638A (pt) 2004-09-21

Family

ID=22243290

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9408638-9A BR9408638A (pt) 1994-12-29 1994-12-29 Geração de insulina humana

Country Status (15)

Country Link
EP (1) EP0871474B2 (pt)
JP (1) JP4624495B2 (pt)
AT (1) ATE350053T1 (pt)
AU (1) AU698872B2 (pt)
BR (1) BR9408638A (pt)
CA (1) CA2208095C (pt)
CZ (1) CZ290079B6 (pt)
DE (2) DE69434909T3 (pt)
DK (1) DK0871474T4 (pt)
ES (1) ES2279510T5 (pt)
HU (1) HU223718B1 (pt)
NZ (1) NZ279002A (pt)
PL (1) PL180818B1 (pt)
PT (1) PT871474E (pt)
WO (1) WO1996020724A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
US6924120B1 (en) 1998-03-31 2005-08-02 Tonghua Gantech Biotechnology, Ltd. Chaperone protein containing an intramolecular chaperone-like sequence and its application to insulin production
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
DK1265630T3 (da) 2000-03-24 2006-10-09 Genentech Inc Anvendelse af insulin til behandling af brusksygdomme
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
DE60138572D1 (de) 2000-07-31 2009-06-10 Univ Bar Ilan Methoden und pharmazeutische zusammensetzungen zur wundheilung
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
ES2306981T3 (es) 2003-01-31 2008-11-16 N.V. Organon Metodo para aislamiento de proteinas en condiciones anoxicas.
DK1651161T3 (da) 2003-08-07 2012-01-30 Healor Ltd Farmaceutiske præparater og fremgangsmåder til at fremme sårheling
US9074015B2 (en) * 2010-07-28 2015-07-07 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
WO2012048856A1 (en) 2010-10-12 2012-04-19 Glucometrix Pvs Gmbh Proinsulin with helper sequence
WO2012098009A1 (en) 2011-01-21 2012-07-26 Glucometrix Ag Chimeric polypeptide comprising a membrane protein and an insulin precursor
EP2867250A2 (en) 2012-04-04 2015-05-06 GlucoMetrix AG Proinsulin with enhanced helper sequence
CA2866491A1 (en) * 2014-10-02 2016-04-02 Clay Purdy Synthetic acid compositions and uses thereof
EP3341405A4 (en) * 2015-09-24 2019-05-01 Hanmi Pharm. Co., Ltd. PROCESS FOR INSULIN PRODUCTION
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
BR112019004314A2 (pt) * 2016-09-06 2019-05-28 Chemical & Biopharmaceutical Laboratories Of Patras S A derivados pró-insulina
BR112019005637A2 (pt) * 2016-09-23 2019-07-30 Hanmi Pharm Ind Co Ltd análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
JP2021532730A (ja) * 2018-06-18 2021-12-02 ユニケム ラボラトリーズ リミテッド 組換えタンパク質の発現レベルを高めるためのリーダー配列
CN112584853B (zh) * 2018-09-12 2021-12-10 美药星（南京）制药有限公司 一种新型门冬胰岛素原的结构和制备门冬胰岛素的方法
CN113226284B (zh) 2018-09-25 2024-12-03 美药星制药股份有限公司 高度纯化的重组人胰岛素（rhi）api及其生产方法
CN113527505A (zh) * 2020-04-15 2021-10-22 博锐生物科技有限公司 一种多肽和包含该多肽的药物组合物以及它们的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
US5342921A (en) * 1985-03-28 1994-08-30 Chiron Corporation Superoxide dismutase fusion polypeptides for expression of mammalian proteins
CA1260858A (en) † 1985-03-28 1989-09-26 Lawrence S. Cousens Expression using fused genes providing for protein product
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
IL104727A (en) * 1992-02-18 1997-01-10 Lilly Co Eli Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
DE19701167A1 (de) * 1997-01-15 1998-07-23 Siemens Ag Chipkarte

Also Published As

Publication number Publication date
EP0871474A4 (en) 2004-08-18
AU698872B2 (en) 1998-11-12
CA2208095A1 (en) 1996-07-11
DE69434909D1 (de) 2007-02-15
ES2279510T5 (es) 2012-01-19
NZ279002A (en) 1999-02-25
ATE350053T1 (de) 2007-01-15
DE69434909T3 (de) 2012-02-09
EP0871474B1 (en) 2007-01-03
PL180818B1 (pl) 2001-04-30
HU223718B1 (hu) 2004-12-28
EP0871474B2 (en) 2011-09-21
PL321039A1 (en) 1997-11-24
DK0871474T4 (da) 2012-01-09
HUT78070A (hu) 1999-08-30
EP0871474A1 (en) 1998-10-21
CZ203197A3 (cs) 1998-09-16
WO1996020724A1 (en) 1996-07-11
DK0871474T3 (da) 2007-05-07
JP4624495B2 (ja) 2011-02-02
CZ290079B6 (cs) 2002-05-15
DE95907193T1 (de) 2005-02-10
PT871474E (pt) 2007-02-28
CA2208095C (en) 2006-11-28
JPH10511849A (ja) 1998-11-17
ES2279510T3 (es) 2007-08-16
HK1013594A1 (en) 1999-09-03
AU1550095A (en) 1996-07-24
DE69434909T2 (de) 2007-08-09

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Legal Events

Date Code Title Description
B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 37 DA LPI LEI N 9279 DE 14 DE MAIO DE 1996 CONCLUIMOS O EXAME INDEFERINDO OPRESENTE PEDIDO COM BASE NO ARTIGO 229 DA LEI N 10.196 DE 14 DE FEVEREIRO DE 2001.

B12B Appeal against refusal [chapter 12.2 patent gazette]