DK0871474T3 - Generering af humant insulin - Google Patents

Generering af humant insulin

Info

Publication number
DK0871474T3
DK0871474T3 DK95907193T DK95907193T DK0871474T3 DK 0871474 T3 DK0871474 T3 DK 0871474T3 DK 95907193 T DK95907193 T DK 95907193T DK 95907193 T DK95907193 T DK 95907193T DK 0871474 T3 DK0871474 T3 DK 0871474T3
Authority
DK
Denmark
Prior art keywords
human insulin
folded
polypeptide
insulin generation
new
Prior art date
Application number
DK95907193T
Other languages
English (en)
Other versions
DK0871474T4 (da
Inventor
Jacob R Hartman
Simona Mendelovitz
Marian Gorecki
Original Assignee
Ferring Int Ct Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22243290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0871474(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Int Ct Sa filed Critical Ferring Int Ct Sa
Application granted granted Critical
Publication of DK0871474T3 publication Critical patent/DK0871474T3/da
Publication of DK0871474T4 publication Critical patent/DK0871474T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
DK95907193.7T 1994-12-29 1994-12-29 Fremstilling af human insulin DK0871474T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/013268 WO1996020724A1 (en) 1994-12-29 1994-12-29 Generation of human insulin

Publications (2)

Publication Number Publication Date
DK0871474T3 true DK0871474T3 (da) 2007-05-07
DK0871474T4 DK0871474T4 (da) 2012-01-09

Family

ID=22243290

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95907193.7T DK0871474T4 (da) 1994-12-29 1994-12-29 Fremstilling af human insulin

Country Status (15)

Country Link
EP (1) EP0871474B2 (da)
JP (1) JP4624495B2 (da)
AT (1) ATE350053T1 (da)
AU (1) AU698872B2 (da)
BR (1) BR9408638A (da)
CA (1) CA2208095C (da)
CZ (1) CZ290079B6 (da)
DE (2) DE95907193T1 (da)
DK (1) DK0871474T4 (da)
ES (1) ES2279510T5 (da)
HU (1) HU223718B1 (da)
NZ (1) NZ279002A (da)
PL (1) PL180818B1 (da)
PT (1) PT871474E (da)
WO (1) WO1996020724A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE69840035D1 (de) 1998-03-31 2008-10-30 Tonghua Gantech Biotechnology Chimäres protein welches eine intramolekulare chap zur insulinproduktion
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
DE60120372T2 (de) 2000-03-24 2007-07-05 Genentech Inc., San Francisco Verwendung von insulin zur behandlung von knorpelkrankheiten
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
CA2416788A1 (en) 2000-07-31 2002-02-07 Tamar Tennenbaum Methods and pharmaceutical compositions comprising protein kinase c isoforms for healing wounds
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
CA2514416C (en) 2003-01-31 2012-08-14 Akzo Nobel N.V. Method for protein isolation in anoxic conditions
WO2005013885A2 (en) 2003-08-07 2005-02-17 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
JP2013535467A (ja) * 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
WO2012048856A1 (en) 2010-10-12 2012-04-19 Glucometrix Pvs Gmbh Proinsulin with helper sequence
WO2012098009A1 (en) 2011-01-21 2012-07-26 Glucometrix Ag Chimeric polypeptide comprising a membrane protein and an insulin precursor
EP2867250A2 (en) 2012-04-04 2015-05-06 GlucoMetrix AG Proinsulin with enhanced helper sequence
CA2866491A1 (en) * 2014-10-02 2016-04-02 Clay Purdy Synthetic acid compositions and uses thereof
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
EP3509625A1 (en) * 2016-09-06 2019-07-17 Chemical & Biopharmaceutical Laboratories of Patras S.A. Proinsulin derivatives
JP7158378B2 (ja) * 2016-09-23 2022-10-21 ハンミ ファーマシューティカル カンパニー リミテッド インスリン受容体との結合力が減少された、インスリンアナログ及びその用途
CN112105635A (zh) * 2018-06-18 2020-12-18 联合化学实验室有限公司 用于重组蛋白的更高表达的前导序列
EP3845240B1 (en) * 2018-09-12 2024-11-06 Amphastar Nanjing Pharmaceuticals, Inc. Pro-insulin aspart structure and method for preparing insulin aspart
US11524987B2 (en) 2018-09-25 2022-12-13 Amphastar Pharmaceuticals, Inc. Highly purified recombinant human insulin (RHI) API and methods of producing the same
CN113527505A (zh) * 2020-04-15 2021-10-22 博锐生物科技有限公司 一种多肽和包含该多肽的药物组合物以及它们的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
CA1260858A (en) † 1985-03-28 1989-09-26 Lawrence S. Cousens Expression using fused genes providing for protein product
US5342921A (en) * 1985-03-28 1994-08-30 Chiron Corporation Superoxide dismutase fusion polypeptides for expression of mammalian proteins
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
IL104727A (en) * 1992-02-18 1997-01-10 Lilly Co Eli Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
DE19701167A1 (de) * 1997-01-15 1998-07-23 Siemens Ag Chipkarte

Also Published As

Publication number Publication date
DE95907193T1 (de) 2005-02-10
BR9408638A (pt) 2004-09-21
DK0871474T4 (da) 2012-01-09
JP4624495B2 (ja) 2011-02-02
DE69434909D1 (de) 2007-02-15
DE69434909T3 (de) 2012-02-09
PL180818B1 (pl) 2001-04-30
HK1013594A1 (en) 1999-09-03
EP0871474B2 (en) 2011-09-21
JPH10511849A (ja) 1998-11-17
ES2279510T5 (es) 2012-01-19
ES2279510T3 (es) 2007-08-16
CA2208095A1 (en) 1996-07-11
DE69434909T2 (de) 2007-08-09
EP0871474B1 (en) 2007-01-03
HUT78070A (hu) 1999-08-30
WO1996020724A1 (en) 1996-07-11
CA2208095C (en) 2006-11-28
CZ203197A3 (cs) 1998-09-16
CZ290079B6 (cs) 2002-05-15
PL321039A1 (en) 1997-11-24
EP0871474A4 (en) 2004-08-18
EP0871474A1 (en) 1998-10-21
AU698872B2 (en) 1998-11-12
HU223718B1 (hu) 2004-12-28
NZ279002A (en) 1999-02-25
PT871474E (pt) 2007-02-28
AU1550095A (en) 1996-07-24
ATE350053T1 (de) 2007-01-15

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