BR9609871A - Vacina de urease recombinante multimérica - Google Patents

Vacina de urease recombinante multimérica

Info

Publication number
BR9609871A
BR9609871A BR9609871-6A BR9609871A BR9609871A BR 9609871 A BR9609871 A BR 9609871A BR 9609871 A BR9609871 A BR 9609871A BR 9609871 A BR9609871 A BR 9609871A
Authority
BR
Brazil
Prior art keywords
compositions
multimeric
helicobacter
processes
recombinant urease
Prior art date
Application number
BR9609871-6A
Other languages
English (en)
Inventor
Cynthia K Lee
Thomas P Monath
Samuel K Ackerman
William D Thomas Jr.
Gopalan Soman
Harold Kleanthous
Richard A Weltzin
Jacques Pappo
Thomas Ermak
Farshad Guirakhoo
Hitesh Bhagat
Ilene Sussman
Original Assignee
Ora Vax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ora Vax Inc filed Critical Ora Vax Inc
Publication of BR9609871A publication Critical patent/BR9609871A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"VACINA UREASE RECOMBINANTE MULTIMéRICA"<D>. São fornecidos processos e composições para evitar e/ou tratar infecção Helicobacter (por exemplo, H. pylori). As composições da invenção, que são usadas nos processos da invenção (que incluem administração mucosal das composições), incluem composições contendo complexos multiméricos de urease recombinante de Helicobacter enzimaticamente ativa em um veículo ou diluente farmaceuticamente aceitável; e composições contendo (a) um antígeno de Helicobacter e (b0 um antibiótico, um agente anti-secretório, um sal de bismuto ou uma combinação dos mesmos.
BR9609871-6A 1995-04-28 1996-04-25 Vacina de urease recombinante multimérica BR9609871A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43104195A 1995-04-28 1995-04-28
US56812295A 1995-12-06 1995-12-06
PCT/US1996/005800 WO1996033732A1 (en) 1995-04-28 1996-04-25 Multimeric, recombinant urease vaccine

Publications (1)

Publication Number Publication Date
BR9609871A true BR9609871A (pt) 2000-03-28

Family

ID=27028868

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9609871-6A BR9609871A (pt) 1995-04-28 1996-04-25 Vacina de urease recombinante multimérica

Country Status (15)

Country Link
EP (1) EP0831892B1 (pt)
JP (1) JPH11504633A (pt)
KR (1) KR19990008155A (pt)
AT (1) ATE433325T1 (pt)
AU (1) AU723063B2 (pt)
BR (1) BR9609871A (pt)
CA (1) CA2219201A1 (pt)
CZ (1) CZ342697A3 (pt)
DE (1) DE69637947D1 (pt)
HU (1) HUP9801266A3 (pt)
MX (1) MX9708319A (pt)
NO (1) NO974969L (pt)
NZ (1) NZ307017A (pt)
PL (1) PL185013B1 (pt)
WO (1) WO1996033732A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
DE19521314A1 (de) * 1995-06-12 1996-12-19 Max Planck Gesellschaft Adhärenzgen aus Helicobacter pylori und davon codiertes Polypeptid
EP0835928A1 (en) * 1996-10-11 1998-04-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Helicobacter pylori live vaccine
WO1998021225A1 (en) * 1996-11-14 1998-05-22 Merieux Oravax Helicobacter polypeptides and corresponding polynucleotide molecules
US6248551B1 (en) * 1997-03-28 2001-06-19 Institut Pasteur Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
US6599509B2 (en) 1997-09-02 2003-07-29 Massachusetts Institute Of Technology Compositions and methods comprising helicobacter antigens for treatment and prevention of inflammatory bowel disease
GB9718616D0 (en) * 1997-09-02 1997-11-05 Queen Mary & Westfield College Oral vaccine
US5985631A (en) * 1997-09-12 1999-11-16 Oravax-Merieux Co. Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
US6576244B1 (en) 1998-06-19 2003-06-10 Acambis, Inc. LT and CT in parenteral immunization methods against helicobacter infection
US6190667B1 (en) 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
AU8464398A (en) * 1998-07-16 2000-02-07 Cheil Jedang Corporation Urease based vaccine against (helicobacter) infection
IL162857A0 (en) * 2002-01-15 2005-11-20 Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh Oral vaccination
EP1327450B1 (de) * 2002-01-15 2007-08-15 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. Orale Vakzinierung mit nackten Tumor-Antigen-Mimotopen
WO2005113603A1 (en) * 2004-05-18 2005-12-01 Universite De Lausanne Eradication of helicobacter infection by activation of stomach mast cells
CN100460013C (zh) * 2006-09-05 2009-02-11 重庆康卫生物科技有限公司 口服重组幽门螺杆菌疫苗及其制备方法
CN100535119C (zh) * 2006-11-07 2009-09-02 上海交通大学医学院附属第九人民医院 一种制备唾液链球菌尿素酶基因的方法
CN101955545B (zh) * 2010-09-07 2012-07-04 四川万可泰生物技术有限责任公司 一种多靶点重组基因及其蛋白在防治幽门螺旋杆菌感染中的应用
CN113433087A (zh) * 2021-06-22 2021-09-24 中南大学 一种尿素浓度快速检测方法及检测传感器和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
JPH08509873A (ja) * 1993-05-19 1996-10-22 アンスティテュ・パストゥール ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列
FR2732605B1 (fr) * 1995-04-07 1997-05-16 Pasteur Merieux Serums Vacc Composition destinee a l'induction d'une reponse immunitaire mucosale

Also Published As

Publication number Publication date
HUP9801266A3 (en) 1999-07-28
PL185013B1 (pl) 2003-01-31
CZ342697A3 (cs) 1998-06-17
KR19990008155A (ko) 1999-01-25
NZ307017A (en) 1999-07-29
NO974969L (no) 1997-12-23
NO974969D0 (no) 1997-10-27
JPH11504633A (ja) 1999-04-27
PL323048A1 (en) 1998-03-02
EP0831892A1 (en) 1998-04-01
AU5576496A (en) 1996-11-18
EP0831892B1 (en) 2009-06-10
WO1996033732A1 (en) 1996-10-31
HUP9801266A2 (hu) 1998-08-28
ATE433325T1 (de) 2009-06-15
MX9708319A (es) 1998-08-30
CA2219201A1 (en) 1996-10-31
EP0831892A4 (en) 2002-06-26
AU723063B2 (en) 2000-08-17
DE69637947D1 (de) 2009-07-23

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Legal Events

Date Code Title Description
FB34 Technical and formal requirements: requirement - article 34 of industrial property law
FA14 Dismissal: dismissal - article 34 of industrial property law
B11T Dismissal of application maintained [chapter 11.20 patent gazette]