BR9609914A - Antagonista do receptor de endotelina - Google Patents

Antagonista do receptor de endotelina

Info

Publication number: BR9609914A
Authority: BR; Brazil
Prior art keywords: receptor antagonist; endothelin receptor; endothelin; antagonist; receptor
Prior art date: 1995-08-02

Application number

BR9609914A

Other languages

English (en)

Inventor

Juan Ignacio Luengo

John Duncan Elliott

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-02

Filing date

1996-08-02

Publication date

1999-07-06

1996-08-02 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1999-07-06 Publication of BR9609914A publication Critical patent/BR9609914A/pt

Links

229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

BR9609914A 1995-08-02 1996-08-02 Antagonista do receptor de endotelina BR9609914A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US179295P	1995-08-02	1995-08-02
US1098296P	1996-02-01	1996-02-01
PCT/US1996/012581 WO1997004772A1 (en)	1995-08-02	1996-08-02	Endothelin receptor antagonists

Publications (1)

Publication Number	Publication Date
BR9609914A true BR9609914A (pt)	1999-07-06

Family

ID=26669471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9609914A BR9609914A (pt)	1995-08-02	1996-08-02	Antagonista do receptor de endotelina

Country Status (25)

Country	Link
US (5)	US5969151A (pt)
EP (2)	EP0843551B1 (pt)
JP (2)	JPH11511133A (pt)
KR (1)	KR19990036032A (pt)
CN (1)	CN1196680A (pt)
AP (1)	AP9801182A0 (pt)
AT (1)	ATE341324T1 (pt)
AU (2)	AU6646396A (pt)
BG (1)	BG102229A (pt)
BR (1)	BR9609914A (pt)
CA (2)	CA2228293A1 (pt)
CZ (1)	CZ30498A3 (pt)
DE (2)	DE69636597T2 (pt)
EA (1)	EA000952B1 (pt)
ES (2)	ES2273350T3 (pt)
HU (1)	HU220776B1 (pt)
MX (1)	MX9800975A (pt)
NO (1)	NO980422L (pt)
NZ (1)	NZ315846A (pt)
OA (1)	OA10755A (pt)
PL (1)	PL184272B1 (pt)
RO (1)	RO115802B1 (pt)
SK (1)	SK282584B6 (pt)
TR (1)	TR199800152T1 (pt)
WO (2)	WO1997004772A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO5021171A1 (es) *	1997-12-08	2001-03-27	Smithkline Beechman Corp	Sal de monoargininilo del acido(e)-3-(1-n-butil-5-(2-(2- carboxifenil)metoxi-4-clorofenil)-1h-pirazol-4-il)-2- ((5-metoxi-2,3-dihidrobenzofuran-5-il)metil)-prop-2-enoico
DE10155076A1 (de) *	2001-11-09	2003-05-22	Merck Patent Gmbh	Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
CA2489428A1 (en) *	2002-06-27	2004-01-08	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2006075955A1 (en) *	2005-01-13	2006-07-20	Astrazeneca Ab	Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) *	2005-02-18	2009-04-21	Pharma Diagnostics, N.V.	Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en)	2008-12-11	2011-09-06	Taylor Made Golf Company, Inc.	Golf club head
US10086240B1 (en)	2015-08-14	2018-10-02	Taylor Made Golf Company, Inc.	Golf club head
EP3380970B1 (en)	2015-11-24	2023-01-04	Sanford Burnham Prebys Medical Discovery Institute	Novel azole derivatives as apelin receptor agonist
US10773135B1 (en)	2019-08-28	2020-09-15	Taylor Made Golf Company, Inc.	Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1937241A1 (de) *	1968-08-02	1970-02-19	Sumitomo Chemical Co	3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) *	1988-02-16	1989-08-24	Tanabe Seiyaku Co Ltd	ベンゾジオキソール誘導体
EP0403158A3 (en) *	1989-06-14	1991-12-18	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids
EP0563238B1 (en) *	1990-12-14	2002-05-22	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids
FR2682379B1 (fr) *	1991-10-09	1994-02-11	Rhone Poulenc Agrochimie	Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) *	1993-03-31	1994-10-13	Smithkline Beecham Corporation	Chemical compounds
WO1995005374A1 (en) *	1993-08-18	1995-02-23	Banyu Pharmaceutical Co., Ltd.	Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity
IL111613A0 (en) *	1993-11-12	1995-01-24	Rhone Poulenc Rorer Ltd	Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
EP0778833B1 (en) *	1994-09-02	2002-05-15	SmithKline Beecham Corporation	Endothelin receptor antagonists

1996
- 1996-08-02 WO PCT/US1996/012581 patent/WO1997004772A1/en not_active Ceased
- 1996-08-02 JP JP9507907A patent/JPH11511133A/ja not_active Ceased
- 1996-08-02 WO PCT/US1996/012661 patent/WO1997004773A1/en not_active Ceased
- 1996-08-02 CZ CZ98304A patent/CZ30498A3/cs unknown
- 1996-08-02 BR BR9609914A patent/BR9609914A/pt not_active Application Discontinuation
- 1996-08-02 AU AU66463/96A patent/AU6646396A/en not_active Abandoned
- 1996-08-02 HU HU9902817A patent/HU220776B1/hu not_active IP Right Cessation
- 1996-08-02 DE DE69636597T patent/DE69636597T2/de not_active Expired - Fee Related
- 1996-08-02 EP EP96926243A patent/EP0843551B1/en not_active Expired - Lifetime
- 1996-08-02 NZ NZ315846A patent/NZ315846A/xx unknown
- 1996-08-02 DE DE69619116T patent/DE69619116T2/de not_active Expired - Fee Related
- 1996-08-02 RO RO98-00135A patent/RO115802B1/ro unknown
- 1996-08-02 JP JP50788797A patent/JP2001517195A/ja not_active Ceased
- 1996-08-02 CA CA002228293A patent/CA2228293A1/en not_active Abandoned
- 1996-08-02 ES ES96928036T patent/ES2273350T3/es not_active Expired - Lifetime
- 1996-08-02 EA EA199800185A patent/EA000952B1/ru not_active IP Right Cessation
- 1996-08-02 TR TR1998/00152T patent/TR199800152T1/xx unknown
- 1996-08-02 AT AT96928036T patent/ATE341324T1/de not_active IP Right Cessation
- 1996-08-02 CA CA002228296A patent/CA2228296A1/en not_active Abandoned
- 1996-08-02 SK SK113-98A patent/SK282584B6/sk unknown
- 1996-08-02 KR KR1019980700697A patent/KR19990036032A/ko not_active Ceased
- 1996-08-02 AU AU67645/96A patent/AU717172B2/en not_active Ceased
- 1996-08-02 PL PL96324745A patent/PL184272B1/pl not_active IP Right Cessation
- 1996-08-02 EP EP96928036A patent/EP0841925B1/en not_active Expired - Lifetime
- 1996-08-02 CN CN96197111A patent/CN1196680A/zh active Pending
- 1996-08-02 ES ES96926243T patent/ES2171697T3/es not_active Expired - Lifetime
- 1996-08-02 MX MX9800975A patent/MX9800975A/es not_active IP Right Cessation
- 1996-08-02 AP APAP/P/1998/001182A patent/AP9801182A0/en unknown
1998
- 1998-01-28 OA OA9800014A patent/OA10755A/en unknown
- 1998-01-30 NO NO980422A patent/NO980422L/no not_active Application Discontinuation
- 1998-02-02 BG BG102229A patent/BG102229A/xx unknown
- 1998-07-23 US US09/121,545 patent/US5969151A/en not_active Expired - Fee Related
1999
- 1999-01-08 US US09/227,361 patent/US5958968A/en not_active Expired - Fee Related
- 1999-06-29 US US09/342,989 patent/US6096897A/en not_active Expired - Fee Related
- 1999-12-14 US US09/460,487 patent/US6353116B1/en not_active Expired - Fee Related
2001
- 2001-11-30 US US10/021,461 patent/US6482956B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AP9801182A0 (en)	1998-01-31
US6353116B1 (en)	2002-03-05
JP2001517195A (ja)	2001-10-02
EA000952B1 (ru)	2000-08-28
NZ315846A (en)	1999-01-28
EA199800185A1 (ru)	1998-10-29
US6096897A (en)	2000-08-01
ES2171697T3 (es)	2002-09-16
WO1997004772A1 (en)	1997-02-13
AU6646396A (en)	1997-02-26
WO1997004773A1 (en)	1997-02-13
PL324745A1 (en)	1998-06-08
PL184272B1 (pl)	2002-09-30
CN1196680A (zh)	1998-10-21
DE69636597D1 (de)	2006-11-16
DE69636597T2 (de)	2007-08-16
US5969151A (en)	1999-10-19
EP0841925A4 (en)	2001-10-17
HUP9902817A2 (hu)	1999-12-28
EP0843551A1 (en)	1998-05-27
KR19990036032A (ko)	1999-05-25
BG102229A (en)	1998-09-30
SK282584B6 (sk)	2002-10-08
AU6764596A (en)	1997-02-26
TR199800152T1 (xx)	1998-05-21
CA2228296A1 (en)	1997-02-13
HU220776B1 (hu)	2002-05-28
ATE341324T1 (de)	2006-10-15
JPH11511133A (ja)	1999-09-28
EP0841925B1 (en)	2006-10-04
NO980422D0 (no)	1998-01-30
EP0843551B1 (en)	2002-02-06
HUP9902817A3 (en)	2001-03-28
SK11398A3 (en)	1998-07-08
CA2228293A1 (en)	1997-02-13
EP0841925A1 (en)	1998-05-20
NO980422L (no)	1998-03-24
US5958968A (en)	1999-09-28
AU717172B2 (en)	2000-03-16
RO115802B1 (ro)	2000-06-30
ES2273350T3 (es)	2007-05-01
MX9800975A (es)	1998-04-30
DE69619116D1 (de)	2002-03-21
EP0843551A4 (en)	1998-08-12
US6482956B2 (en)	2002-11-19
CZ30498A3 (cs)	1998-07-15
OA10755A (en)	2002-12-13
DE69619116T2 (de)	2002-09-19
US20020072614A1 (en)	2002-06-13

Legal Events

Date	Code	Title	Description
2005-10-25	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-03-28	B09B	Patent application refused [chapter 9.2 patent gazette]

Publication	Publication Date	Title
FI960953A7 (fi)	1996-09-19	Endoteliinireseptoriantagonisteja
BR9407933A (pt)	1996-11-26	Antagonistas de receptores de endotelina
NO972016D0 (no)	1997-04-30	Indolyl-Y-reseptorantagonister
BR9206722A (pt)	1995-07-18	Antagonista receptores de endotelina
BR9612327A (pt)	1999-07-13	Antagonistas receptores de vitronectina
BR9612378A (pt)	1999-07-13	Antagonistas receptores de vitronectina
EP0810994A4 (en)	1998-05-06	FIBRINOGEN RECEPTOR ANTAGONISTS
BR9712248A (pt)	1999-08-24	Antagonista receptores de vitronectina
NO983001D0 (no)	1998-06-26	Vitronectin-reseptor-antagonister
NO983737L (no)	1998-10-14	IL-8 reseptor antagonister
DE69429861D1 (de)	2002-03-21	Endothelin-rezeptor-antagonisten
NO960473D0 (no)	1996-02-05	Substituerte bifenyl-sulfonamid-endotelin-antagonister
BR9507220A (pt)	1997-09-09	Antagonistas de receptores de endotelina
ATE341324T1 (de)	2006-10-15	Endothelin rezeptor antagonisten
BR9606668A (pt)	1997-09-30	Piridazinonas como antagonista de receptor-endotelina
HU9602054D0 (en)	1996-09-30	Endothelin receptor antagonists
EP0854721A4 (en)	1998-12-02	ENDOTHELIN RECEPTOR ANTAGONISTS
EP0841926A4 (en)	1999-08-04	ENDOTHELIN RECEPTOR ANTAGONISTS
BR9603432A (pt)	1998-05-12	Antagonistas de receptores de endotelina
EP0835264A4 (en)	1998-12-30	Human g-protein receptor hcegh45
EP0841916A4 (en)	2001-04-11	ENDOTHELINE RECEPTOR ANTAGONISTS
EP0868180A4 (en)	1999-08-04	ENDOTHELINM RECEPTOR ANTOGONISTS
ZA966593B (en)	1997-03-24	Endothelin receptor antagonists
GB9510203D0 (en)	1995-07-12	Novel endothelin receptor antagonists