BR9609971A - Preparacão de combinacoes farmacêuticas contendo eritropoietina e preparacões de ferro - Google Patents
Preparacão de combinacoes farmacêuticas contendo eritropoietina e preparacões de ferroInfo
- Publication number
- BR9609971A BR9609971A BR9609971-2A BR9609971A BR9609971A BR 9609971 A BR9609971 A BR 9609971A BR 9609971 A BR9609971 A BR 9609971A BR 9609971 A BR9609971 A BR 9609971A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- combinations containing
- pharmaceutical combinations
- iron preparations
- containing erythropoietin
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title abstract 3
- 108090000394 Erythropoietin Proteins 0.000 title abstract 3
- 229940105423 erythropoietin Drugs 0.000 title abstract 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 229940082629 iron antianemic preparations Drugs 0.000 title abstract 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 238000001631 haemodialysis Methods 0.000 abstract 1
- 230000000322 hemodialysis Effects 0.000 abstract 1
- 102000044890 human EPO Human genes 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
<B>"PREPARAçõES DE COMBINAçõES FARMACêUTICAS CONTENDO ERITROPOIETINA E PREPARAçõES DE FERRO"<D>. A presente invenção é dirigida a uma preparação de combinação farmacêutica compreendendo 2.000-7.000 U de eritropoietina humana recombinante (EPO) e 5-20 mg de um complexo de Fe (III), em que o rhEPO e o complexo de Fe (III) podem estar presentes na forma de uma administração separada ou numa forma de administração integrada. A preparação farmacêutica é usada no tratamento de anemias ou um pacientes de hemodiálise.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19535571A DE19535571A1 (de) | 1995-09-14 | 1995-09-14 | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| PCT/EP1996/003997 WO1997009996A1 (de) | 1995-09-14 | 1996-09-12 | Pharmazeutische kombinationspräparate enthaltend erythropoietin und eisenpräparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9609971A true BR9609971A (pt) | 1999-09-14 |
Family
ID=7773098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9609971-2A BR9609971A (pt) | 1995-09-14 | 1996-09-12 | Preparacão de combinacoes farmacêuticas contendo eritropoietina e preparacões de ferro |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6333306B1 (pt) |
| EP (1) | EP0851762B1 (pt) |
| JP (1) | JP4783482B2 (pt) |
| KR (1) | KR100350761B1 (pt) |
| CN (1) | CN1133463C (pt) |
| AT (1) | ATE216256T1 (pt) |
| AU (1) | AU724623B2 (pt) |
| BR (1) | BR9609971A (pt) |
| CA (1) | CA2231192C (pt) |
| CZ (1) | CZ291427B6 (pt) |
| DE (3) | DE19535571A1 (pt) |
| DK (1) | DK0851762T3 (pt) |
| EE (1) | EE03856B1 (pt) |
| ES (1) | ES2174107T3 (pt) |
| HU (1) | HU225363B1 (pt) |
| IL (2) | IL123640A0 (pt) |
| MX (1) | MX9801922A (pt) |
| NO (1) | NO329908B1 (pt) |
| NZ (1) | NZ319132A (pt) |
| PL (1) | PL186776B1 (pt) |
| PT (1) | PT851762E (pt) |
| SK (1) | SK285796B6 (pt) |
| TR (1) | TR199800472T1 (pt) |
| UA (1) | UA57713C2 (pt) |
| WO (1) | WO1997009996A1 (pt) |
| ZA (1) | ZA967732B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ337465A (en) * | 1997-03-18 | 2002-04-26 | Roche Diagnostics Gmbh | Pharmaceutical containing erythropoietin and iron preparations for treating haemodialysis patients or anaemias |
| EP0885613A1 (de) * | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) * | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| ATE355303T1 (de) * | 1998-10-23 | 2006-03-15 | Amgen Inc | Methoden und zusammensetzungen zur prävention und behandlung der anämie |
| US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| CA2431964C (en) | 2000-12-20 | 2013-09-10 | F. Hoffmann-La Roche Ag | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
| EP1909106B1 (en) * | 2001-09-14 | 2013-01-02 | F. Hoffmann-La Roche AG | Differential diagnosis of disorders of iron metabolism by means of four parameters and recommendations for the treatment of these disorders of iron metabolism |
| US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
| US7300915B2 (en) * | 2002-06-05 | 2007-11-27 | The Regents Of The University Of California | Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain |
| US7459435B2 (en) | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7459436B2 (en) | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7964568B2 (en) * | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| RU2273485C2 (ru) * | 2004-05-19 | 2006-04-10 | Виктор Николаевич Алейников | Железосодержащий препарат "феррал" |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| US7586589B2 (en) * | 2005-09-24 | 2009-09-08 | Beckman Coulter, Inc. | Methods of determination of responsiveness to erythropoietin treatment |
| WO2008019214A1 (en) | 2006-08-04 | 2008-02-14 | Prolong Pharmaceuticals, Inc. | Modified erythropoietin |
| CL2008002054A1 (es) * | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| SMT202400092T1 (it) | 2013-06-13 | 2024-05-14 | Akebia Therapeutics Inc | Composizioni e metodi per il trattamento dell'anemia |
| EP3380487B1 (en) | 2015-11-23 | 2020-09-02 | Bristol-Myers Squibb Company | Additive systems for use in protein pegylation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6039681B2 (ja) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤 |
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| US4745099A (en) * | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
| JPS6231A (ja) * | 1985-02-06 | 1987-01-06 | Chugai Pharmaceut Co Ltd | 腎性貧血治療剤 |
| JP2858752B2 (ja) * | 1987-04-10 | 1999-02-17 | オーソ・フアーマシユーチカル・コーポレーシヨン | 正常な哺乳動物のヘマトクリツト値の増大方法 |
-
1995
- 1995-09-14 DE DE19535571A patent/DE19535571A1/de not_active Withdrawn
-
1996
- 1996-09-12 DE DE19680768T patent/DE19680768D2/de not_active Expired - Lifetime
- 1996-09-12 US US09/029,859 patent/US6333306B1/en not_active Expired - Lifetime
- 1996-09-12 DK DK96932503T patent/DK0851762T3/da active
- 1996-09-12 DE DE59609099T patent/DE59609099D1/de not_active Expired - Lifetime
- 1996-09-12 SK SK327-98A patent/SK285796B6/sk not_active IP Right Cessation
- 1996-09-12 BR BR9609971-2A patent/BR9609971A/pt not_active Application Discontinuation
- 1996-09-12 PL PL96325640A patent/PL186776B1/pl unknown
- 1996-09-12 PT PT96932503T patent/PT851762E/pt unknown
- 1996-09-12 WO PCT/EP1996/003997 patent/WO1997009996A1/de not_active Ceased
- 1996-09-12 EE EE9800066A patent/EE03856B1/xx unknown
- 1996-09-12 CA CA002231192A patent/CA2231192C/en not_active Expired - Lifetime
- 1996-09-12 NZ NZ319132A patent/NZ319132A/en not_active IP Right Cessation
- 1996-09-12 TR TR1998/00472T patent/TR199800472T1/xx unknown
- 1996-09-12 IL IL12364096A patent/IL123640A0/xx active IP Right Grant
- 1996-09-12 ES ES96932503T patent/ES2174107T3/es not_active Expired - Lifetime
- 1996-09-12 CZ CZ1998726A patent/CZ291427B6/cs not_active IP Right Cessation
- 1996-09-12 EP EP96932503A patent/EP0851762B1/de not_active Expired - Lifetime
- 1996-09-12 KR KR10-1998-0701860A patent/KR100350761B1/ko not_active Expired - Lifetime
- 1996-09-12 MX MX9801922A patent/MX9801922A/es unknown
- 1996-09-12 JP JP51166197A patent/JP4783482B2/ja not_active Expired - Lifetime
- 1996-09-12 HU HU9900357A patent/HU225363B1/hu unknown
- 1996-09-12 AU AU71282/96A patent/AU724623B2/en not_active Expired
- 1996-09-12 AT AT96932503T patent/ATE216256T1/de active
- 1996-09-12 CN CNB961982845A patent/CN1133463C/zh not_active Expired - Lifetime
- 1996-09-13 ZA ZA9607732A patent/ZA967732B/xx unknown
- 1996-12-09 UA UA98041874A patent/UA57713C2/uk unknown
-
1998
- 1998-03-11 IL IL123640A patent/IL123640A/en not_active IP Right Cessation
- 1998-03-13 NO NO19981136A patent/NO329908B1/no not_active IP Right Cessation
-
2001
- 2001-10-29 US US09/984,268 patent/US20020049161A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO COM BASE NOS ARTIGOS 8O E 11 DA LPI 9.279, DE 14 DE MAIO DE 1996 E 229-A DA LEI NO 10.196, DE 14/02/2001. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |