BR9610331A - Composições farmacêuticas para distribuição nasal de compostos úteis para o tratamento de osteoporose - Google Patents

Composições farmacêuticas para distribuição nasal de compostos úteis para o tratamento de osteoporose

Info

Publication number
BR9610331A
BR9610331A BR9610331-0A BR9610331A BR9610331A BR 9610331 A BR9610331 A BR 9610331A BR 9610331 A BR9610331 A BR 9610331A BR 9610331 A BR9610331 A BR 9610331A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compounds useful
nasal delivery
treating osteoporosis
osteoporosis
Prior art date
Application number
BR9610331-0A
Other languages
English (en)
Inventor
Christin Teresa Piazza
Michael Lloyd Radomsky
John Leonard Krstenansky
Brian Henry Vickery
John Joseph Nestor Jr
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of BR9610331A publication Critical patent/BR9610331A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS PARA DISTRIBUIçãO NASAL DE COMPOSTOS úTEIS PARA O TRATAMENTO DE OSTEOPOROSE". é fornecida uma composição farmacêutica para a distribuição nasal de compostos úteis para tratamento de osteoporose, compreendendo uma quantidade eficaz de um análogo truncado fisiologicamente ativo de PTH ou PTHrp, ou sal do mesmo, no qual resíduos de aminoácidos (22-31) formam uma <244>-hélice anfipática, os referidos resíduos (22-31) selecionados de (SEQ ID N^ os^: 85, 86, 26, 27, 28, 29 e 30); um intensificador de absorção selecionado do grupo que consiste de dimetil-<225>-ciclodextrina e os tensoativos de ácido de bile; e água.
BR9610331-0A 1995-08-29 1996-08-22 Composições farmacêuticas para distribuição nasal de compostos úteis para o tratamento de osteoporose BR9610331A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/521,097 US5977070A (en) 1992-07-14 1995-08-29 Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
PCT/US1996/013769 WO1997007815A2 (en) 1995-08-29 1996-08-22 Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis

Publications (1)

Publication Number Publication Date
BR9610331A true BR9610331A (pt) 2005-05-10

Family

ID=24075345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610331-0A BR9610331A (pt) 1995-08-29 1996-08-22 Composições farmacêuticas para distribuição nasal de compostos úteis para o tratamento de osteoporose

Country Status (9)

Country Link
US (1) US5977070A (pt)
EP (1) EP0858344A2 (pt)
JP (1) JPH11511462A (pt)
CN (1) CN1193915A (pt)
AU (1) AU6958996A (pt)
BR (1) BR9610331A (pt)
CA (1) CA2230929A1 (pt)
TR (1) TR199800335T1 (pt)
WO (1) WO1997007815A2 (pt)

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WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis

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MX9801630A (es) 1998-08-30
AU6958996A (en) 1997-03-19
US5977070A (en) 1999-11-02
CA2230929A1 (en) 1997-03-06
EP0858344A2 (en) 1998-08-19
JPH11511462A (ja) 1999-10-05
CN1193915A (zh) 1998-09-23
WO1997007815A2 (en) 1997-03-06
WO1997007815A3 (en) 1997-09-18
TR199800335T1 (xx) 1998-05-21

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