BR9705143A - Derivados de 10,13,15-trioxatriciclo [9.2.1.1(9.6)] -pentadecanona, processo para a sua preparação e medicamentos que contém estes compostos - Google Patents
Derivados de 10,13,15-trioxatriciclo [9.2.1.1(9.6)] -pentadecanona, processo para a sua preparação e medicamentos que contém estes compostosInfo
- Publication number
- BR9705143A BR9705143A BR9705143-8A BR9705143A BR9705143A BR 9705143 A BR9705143 A BR 9705143A BR 9705143 A BR9705143 A BR 9705143A BR 9705143 A BR9705143 A BR 9705143A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- preparation
- pentadecanone
- compounds
- trioxatriciclo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 abstract 1
- 102000002419 Motilin Human genes 0.000 abstract 1
- 101800002372 Motilin Proteins 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE 10, 13, 15-TRIOXATRICICLO[9.2.1.1.9.6]-PENTADECANONA, PROCESSO PARA A SUA PREPARAçãO E MEDICAMENTOS QUE CONTêM ESTES COMPOSTOS"<D>. Descrevem-se derivados de N-desmetil-N-isopropil-eritromicina-A-espiroacetal restringidos no anel com propriedades agonísticas da motilina gastrintestinalmente ativos e a sua preparação.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19644195A DE19644195A1 (de) | 1996-10-24 | 1996-10-24 | 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9705143A true BR9705143A (pt) | 2000-12-12 |
Family
ID=7809858
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9705143-8A BR9705143A (pt) | 1996-10-24 | 1997-10-24 | Derivados de 10,13,15-trioxatriciclo [9.2.1.1(9.6)] -pentadecanona, processo para a sua preparação e medicamentos que contém estes compostos |
| BR9705157-8A BR9705157A (pt) | 1996-10-24 | 1997-10-24 | Derivados de 10,13,15-trioxatriciclo[9.2.1. 9.6]-pentadecanona, processo para a sua preparação e medicamentos que contêm estes compostos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9705157-8A BR9705157A (pt) | 1996-10-24 | 1997-10-24 | Derivados de 10,13,15-trioxatriciclo[9.2.1. 9.6]-pentadecanona, processo para a sua preparação e medicamentos que contêm estes compostos |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5912235A (pt) |
| EP (1) | EP0838469B1 (pt) |
| JP (1) | JP4175682B2 (pt) |
| KR (1) | KR100466495B1 (pt) |
| CN (1) | CN1093133C (pt) |
| AR (1) | AR009809A1 (pt) |
| AT (1) | ATE211745T1 (pt) |
| AU (1) | AU726092B2 (pt) |
| BR (2) | BR9705143A (pt) |
| CA (1) | CA2219311C (pt) |
| CZ (1) | CZ291768B6 (pt) |
| DE (2) | DE19644195A1 (pt) |
| DK (1) | DK0838469T3 (pt) |
| DZ (1) | DZ2322A1 (pt) |
| ES (1) | ES2170318T3 (pt) |
| HU (1) | HU222540B1 (pt) |
| IL (1) | IL121969A (pt) |
| MX (1) | MX9707974A (pt) |
| NO (1) | NO308362B1 (pt) |
| NZ (1) | NZ328979A (pt) |
| PL (1) | PL184693B1 (pt) |
| PT (1) | PT838469E (pt) |
| RU (1) | RU2181727C2 (pt) |
| SK (1) | SK283114B6 (pt) |
| UA (1) | UA44310C2 (pt) |
| ZA (1) | ZA979059B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998023629A1 (fr) * | 1996-11-26 | 1998-06-04 | Chugai Seiyaku Kabushiki Kaisha | Composes de macrolides comportant une chaine a 13 elements, medicament les contenant et leur procede de preparation |
| ATE321770T1 (de) | 2000-08-17 | 2006-04-15 | Kitasato Inst | Pseudoerythromycin-derivate |
| JP2003007917A (ja) * | 2001-06-19 | 2003-01-10 | Sanyo Electric Co Ltd | 回路装置の製造方法 |
| US6986882B2 (en) * | 2002-01-17 | 2006-01-17 | Astrazeneca Ab | Therapy for functional dyspepsia |
| US7521420B2 (en) | 2003-06-18 | 2009-04-21 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor |
| GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| JP2009501199A (ja) | 2005-07-12 | 2009-01-15 | グラクソ グループ リミテッド | Ｇｐｒ３８アゴニストとしてのピペラジンヘテロアリール誘導体 |
| AU2006274212B2 (en) * | 2005-07-26 | 2011-06-09 | Glaxo Group Limited | Benzylpiperazine derivates and their medical use |
| JP2009518396A (ja) * | 2005-12-08 | 2009-05-07 | ファイザー・インク | エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法 |
| DE602007006019D1 (de) | 2006-06-28 | 2010-06-02 | Glaxo Group Ltd | Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate |
| EP2054429B1 (en) | 2006-09-11 | 2013-11-06 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
| KR101120483B1 (ko) * | 2006-12-05 | 2012-02-29 | 브리스톨-마이어즈 스퀴브 컴페니 | 모틸라이드 다형체 |
| EP2401268B1 (en) | 2009-02-27 | 2015-07-29 | RaQualia Pharma Inc | Oxyindole derivatives with motilin receptor agonistic activity |
| WO2014156339A1 (ja) * | 2013-03-25 | 2014-10-02 | ゼリア新薬工業株式会社 | 食後期の胃運動亢進剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725385A (en) * | 1970-11-02 | 1973-04-03 | Abbott Lab | Process for the demethylation of 3-amino macrolides |
| US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
| US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1996
- 1996-10-24 DE DE19644195A patent/DE19644195A1/de not_active Withdrawn
-
1997
- 1997-09-23 AR ARP970104375A patent/AR009809A1/es active IP Right Grant
- 1997-09-29 DZ DZ970172A patent/DZ2322A1/xx active
- 1997-10-01 CZ CZ19973106A patent/CZ291768B6/cs not_active IP Right Cessation
- 1997-10-07 KR KR1019970051470A patent/KR100466495B1/ko not_active Expired - Fee Related
- 1997-10-09 ZA ZA9709059A patent/ZA979059B/xx unknown
- 1997-10-14 IL IL12196997A patent/IL121969A/xx not_active IP Right Cessation
- 1997-10-16 MX MX9707974A patent/MX9707974A/es not_active IP Right Cessation
- 1997-10-17 EP EP97118000A patent/EP0838469B1/de not_active Expired - Lifetime
- 1997-10-17 DE DE59705964T patent/DE59705964D1/de not_active Expired - Fee Related
- 1997-10-17 SK SK1419-97A patent/SK283114B6/sk not_active IP Right Cessation
- 1997-10-17 NZ NZ328979A patent/NZ328979A/xx unknown
- 1997-10-17 ES ES97118000T patent/ES2170318T3/es not_active Expired - Lifetime
- 1997-10-17 AT AT97118000T patent/ATE211745T1/de not_active IP Right Cessation
- 1997-10-17 PT PT97118000T patent/PT838469E/pt unknown
- 1997-10-17 DK DK97118000T patent/DK0838469T3/da active
- 1997-10-17 HU HU9701660A patent/HU222540B1/hu not_active IP Right Cessation
- 1997-10-21 US US08/954,891 patent/US5912235A/en not_active Expired - Lifetime
- 1997-10-22 CN CN97121157A patent/CN1093133C/zh not_active Expired - Fee Related
- 1997-10-22 AU AU42788/97A patent/AU726092B2/en not_active Ceased
- 1997-10-22 JP JP28986197A patent/JP4175682B2/ja not_active Expired - Fee Related
- 1997-10-23 PL PL97322802A patent/PL184693B1/pl not_active IP Right Cessation
- 1997-10-23 RU RU97117347/04A patent/RU2181727C2/ru not_active IP Right Cessation
- 1997-10-23 UA UA97105178A patent/UA44310C2/uk unknown
- 1997-10-24 BR BR9705143-8A patent/BR9705143A/pt active Search and Examination
- 1997-10-24 NO NO974934A patent/NO308362B1/no not_active IP Right Cessation
- 1997-10-24 BR BR9705157-8A patent/BR9705157A/pt not_active Application Discontinuation
- 1997-10-24 CA CA002219311A patent/CA2219311C/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |