BR9712372A - Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica. - Google Patents

Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica.

Info

Publication number
BR9712372A
BR9712372A BR9712372-2A BR9712372A BR9712372A BR 9712372 A BR9712372 A BR 9712372A BR 9712372 A BR9712372 A BR 9712372A BR 9712372 A BR9712372 A BR 9712372A
Authority
BR
Brazil
Prior art keywords
polymer
nanoparticles formed
compound
pharmaceutical composition
statistically
Prior art date
Application number
BR9712372-2A
Other languages
English (en)
Inventor
Nicole Bru-Magniez
Xavier Guillon
Pascal Breton
Patric Couvreur
Francois Lescure
Claude Roques-Carmes
Gerard Riess
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of BR9712372A publication Critical patent/BR9712372A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/12—Esters of phenols or saturated alcohols
    • C08F22/14—Esters having no free carboxylic acid groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE NANOPARTìCULAS FORMADAS POR UM POLìMERO ESTATìSTICO, NANOPARTìCULAS FOMADAS POR UM POLìMERO ESTATìSTICO DE PELO MENOS UM COMPOSTO, E, COMPOSIçãO FARMACêUTICAS". A invenção refere-se a um processo de preparação de nanopartículas formadas por um polímero estatístico de pelo menos um composto de fórmula (I) na qual A representa um grupo (a) ou um grupo (b), R~ 1~ e R~ 2~, idênticos ou diferentes, representam um grupo C~ 1~ -C~ 6~ alquila linear ou ramificado; n = 1, 2, 3,4 ou 5, caracterizado pelo fato do monómero ser previamente solubilizado em um solvente orgânico aprótico miscível em água, formando com o meio de polimerização uma mistura não solvente para o polímero formado. A invenção refere-se igualmente as ditas manopartículas, contendo eventualmente uma ou mais moléculas biologicamente ativas, e composições farmacêuticas contendo as mesmas.
BR9712372-2A 1996-10-25 1997-10-24 Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica. BR9712372A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9613039A FR2755136B1 (fr) 1996-10-25 1996-10-25 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant
PCT/FR1997/001907 WO1998018455A1 (fr) 1996-10-25 1997-10-24 Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives

Publications (1)

Publication Number Publication Date
BR9712372A true BR9712372A (pt) 2000-01-25

Family

ID=9497032

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712372-2A BR9712372A (pt) 1996-10-25 1997-10-24 Processo para preparação de nanopartìculas formadas por um polìmero estatìstico, nanopartìculas formadas por um polìmero de pelo menos um composto, e, composição farmacêutica.

Country Status (23)

Country Link
US (2) US6211273B1 (pt)
EP (1) EP0934059B1 (pt)
JP (1) JP2001504530A (pt)
KR (1) KR20000052813A (pt)
CN (1) CN1237903A (pt)
AR (1) AR009127A1 (pt)
AT (1) ATE245171T1 (pt)
AU (1) AU736097B2 (pt)
BR (1) BR9712372A (pt)
CA (1) CA2269783C (pt)
CZ (1) CZ144099A3 (pt)
DE (1) DE69723571T2 (pt)
FR (1) FR2755136B1 (pt)
HU (1) HUP9904359A3 (pt)
IL (1) IL129355A0 (pt)
NO (1) NO991942L (pt)
NZ (1) NZ335094A (pt)
PL (1) PL332957A1 (pt)
RU (1) RU2214421C2 (pt)
SK (1) SK55599A3 (pt)
TW (1) TW503109B (pt)
WO (1) WO1998018455A1 (pt)
ZA (1) ZA979550B (pt)

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FR2774096B1 (fr) * 1998-01-29 2000-04-07 Virsol Nouveaux copolymeres tensioactifs a base de methylidene malonate
FR2778100B1 (fr) * 1998-04-29 2001-05-04 Virsol Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
FR2789314B1 (fr) * 1999-02-09 2001-04-27 Virsol Materiau de suture de plaies a base de methylidene malonate
GB2381792B (en) * 2000-04-12 2004-08-04 Dainippon Ink & Chemicals Antifouling coating composituion
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
WO2002030399A2 (en) * 2000-10-11 2002-04-18 Johns Hopkins University Polymer controlled delivery of a therapeutic agent
KR100457824B1 (ko) * 2001-08-10 2004-11-18 한국화학연구원 용액 열분해법에 의한 나노 크기 2가 금속 산화물 분말의제조
JP3961312B2 (ja) 2002-02-26 2007-08-22 株式会社デンソー 内燃機関の制御装置
US8697120B2 (en) * 2006-05-01 2014-04-15 Johns Hopkins University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2123262A1 (en) * 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
RU2390016C2 (ru) * 2008-06-16 2010-05-20 Государственное образовательное учреждение высшего профессионального образования Иркутский государственный университет путей сообщения (ИрГУПС (ИрИИТ)) Способ определения рифампицина
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US8975435B2 (en) 2009-05-07 2015-03-10 Optmed, Inc. Methylidene malonate process
JP2014503474A (ja) 2010-10-20 2014-02-13 バイオフオーミツクス・インコーポレイテツド エネルギー移動手段の存在下での急速回収を用いたメチレンマロナートの合成
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
EP2768917B1 (en) 2011-10-19 2018-12-05 Sirrus, Inc. Multifunctional monomers and methods for making them
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
WO2014085570A1 (en) 2012-11-30 2014-06-05 Bioformix, Inc. Composite compositions for electronics applications
WO2014110388A1 (en) 2013-01-11 2014-07-17 Bioformix Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
WO2016205605A1 (en) * 2015-06-19 2016-12-22 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
JP7663319B2 (ja) 2017-06-02 2025-04-16 アルケマ フランス 硬化性組成物及びその使用
WO2020123579A1 (en) * 2018-12-11 2020-06-18 Sirrus, Inc. Polymerization of 1,1-dicarbonyl 1-alkenes
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Also Published As

Publication number Publication date
US6420468B2 (en) 2002-07-16
EP0934059B1 (fr) 2003-07-16
NO991942D0 (no) 1999-04-23
CN1237903A (zh) 1999-12-08
CA2269783A1 (en) 1998-05-07
ZA979550B (en) 1998-05-12
DE69723571D1 (de) 2003-08-21
HUP9904359A2 (hu) 2000-05-28
IL129355A0 (en) 2000-02-17
KR20000052813A (ko) 2000-08-25
EP0934059A1 (fr) 1999-08-11
ATE245171T1 (de) 2003-08-15
CZ144099A3 (cs) 1999-09-15
RU2214421C2 (ru) 2003-10-20
US20010006989A1 (en) 2001-07-05
TW503109B (en) 2002-09-21
SK55599A3 (en) 2000-03-13
AU736097B2 (en) 2001-07-26
AR009127A1 (es) 2000-03-08
HUP9904359A3 (en) 2000-11-28
PL332957A1 (en) 1999-10-25
NZ335094A (en) 2001-05-25
CA2269783C (en) 2005-01-11
FR2755136A1 (fr) 1998-04-30
NO991942L (no) 1999-06-23
AU4950997A (en) 1998-05-22
DE69723571T2 (de) 2004-06-03
JP2001504530A (ja) 2001-04-03
WO1998018455A1 (fr) 1998-05-07
FR2755136B1 (fr) 1999-01-22
US6211273B1 (en) 2001-04-03

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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