BR9809643A - Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm - Google Patents

Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm

Info

Publication number
BR9809643A
BR9809643A BR9809643-5A BR9809643A BR9809643A BR 9809643 A BR9809643 A BR 9809643A BR 9809643 A BR9809643 A BR 9809643A BR 9809643 A BR9809643 A BR 9809643A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
preparation process
compositions containing
heterocyclic compounds
compounds
Prior art date
Application number
BR9809643-5A
Other languages
English (en)
Inventor
Gerald Guillaumet
Marie-Claude Viaud
Ahmed Mamai
Isabelle Charton
Pierre Renard
Caroline Bennejean
Beatrice Guardiola
Philippe Daubos
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BR9809643A publication Critical patent/BR9809643A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS HETEROCìCLICOS, SEU PROCESSO DE PREPARO E AS COMPOSIçõES FARMACêUTICAS QUE OS CONTêM"<D>. A invenção refere-se aos compostos de fórmula (I), na qual: R¹, R² e R³ são tais como definidos na descrição, X é tal como definido na descrição, Y representa um átomo de oxigênio, um átomo de enxofre, um grupamento CH~ q~, SO ou SO~ 2~, n vale de 0 a 5, A representa um grupamento NR^ 5^R^6^ ou CZNR^ 8^R^ 9^, medicamentos.
BR9809643-5A 1997-05-16 1998-05-14 Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm BR9809643A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706019A FR2763335B1 (fr) 1997-05-16 1997-05-16 Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1998/000954 WO1998052935A1 (fr) 1997-05-16 1998-05-14 Composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR9809643A true BR9809643A (pt) 2000-10-03

Family

ID=9506957

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809643-5A BR9809643A (pt) 1997-05-16 1998-05-14 Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm

Country Status (20)

Country Link
US (2) US6313160B1 (pt)
EP (1) EP0998471B1 (pt)
JP (1) JP2002510290A (pt)
CN (1) CN1139584C (pt)
AT (1) ATE356814T1 (pt)
AU (1) AU741753B2 (pt)
BR (1) BR9809643A (pt)
CA (1) CA2289599C (pt)
CY (1) CY1106545T1 (pt)
DE (1) DE69837334T2 (pt)
DK (1) DK0998471T3 (pt)
ES (1) ES2285775T3 (pt)
FR (1) FR2763335B1 (pt)
HU (1) HUP0003127A3 (pt)
NO (1) NO324562B1 (pt)
NZ (1) NZ500952A (pt)
PL (1) PL197156B1 (pt)
PT (1) PT998471E (pt)
WO (1) WO1998052935A1 (pt)
ZA (1) ZA984114B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2001042234A1 (en) * 1999-12-13 2001-06-14 Chugai Seiyaku Kabushiki Kaisha 3-methyl-chroman and -thiochroman derivatives
DE10344412A1 (de) * 2003-09-25 2005-05-19 Röhm GmbH & Co. KG Polymernetzwerke
JP2008538576A (ja) * 2005-04-22 2008-10-30 ワイス クロマンおよびクロメン誘導体およびその使用
CN1891687B (zh) * 2005-07-08 2011-08-03 中国医学科学院医药生物技术研究所 微生物来源的炎症因子受体拮抗活性化合物及其应用
DK2123265T3 (da) * 2008-05-23 2012-09-03 Novaera S R L Endipalenformuleringer til behandling af psoriasis
CN102724975B (zh) 2009-11-03 2015-12-02 满康德股份有限公司 IRE-1α抑制剂
KR102022154B1 (ko) * 2016-11-24 2019-09-18 한양대학교 산학협력단 MBD2-p66α(GATAD2A)의 상호작용을 억제하는 화합물을 포함하는 암 전이 억제 및 암 질환 예방 및 치료용 조성물
US10052326B1 (en) 2017-10-12 2018-08-21 King Saud University Antihepatotoxic agents
CN111892516A (zh) * 2018-08-08 2020-11-06 中国人民解放军总医院 抗肿瘤化合物
CN120058664B (zh) * 2025-02-26 2025-10-24 宜昌市中心人民医院(三峡大学第一临床医学院、三峡大学附属中心人民医院) 一种褪黑素受体激动剂及其制备方法和用途

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663702A (en) * 1967-05-05 1972-05-16 Colgate Palmolive Co Pharmaceutical compositions containing amides of beta-(3 - thianaphthenyl)ethylamines
US3511851A (en) * 1967-06-12 1970-05-12 Du Pont Heterocyclic amino-oxazolines
US4046762A (en) * 1972-10-20 1977-09-06 Instituto Luso Farmaco D'italia S.R.L. Esters and amides of 3-aryl-1,4 benzodioxan-2-carboxylic acids
DE2811236A1 (de) * 1977-03-17 1978-09-28 Shell Int Research Biologisch wirksame mittel
BE868304A (nl) * 1977-06-30 1978-12-21 Shell Int Research Werkwijze ter bereiding van een verbinding voor het tegengaan van lipogenese.
US4205079A (en) * 1978-10-16 1980-05-27 Shell Oil Company Benzodioxincarboxamides
ATE23337T1 (de) * 1982-12-23 1986-11-15 Ici America Inc Chromanverbindungen.
GB8515389D0 (en) * 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
FR2618437B1 (fr) * 1987-07-23 1989-11-17 Rhone Poulenc Sante Nouveaux derives du benzopyranne, leur preparation et les medicaments qui les contiennent
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
JPH04500075A (ja) * 1988-08-16 1992-01-09 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 殺菌性ベンゾジオキサンアミン誘導体
EP0389425B1 (de) * 1989-03-22 1995-04-26 Ciba-Geigy Ag Neue Benzothiopyranylamine
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2661676A1 (fr) * 1990-05-02 1991-11-08 Lipha Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
WO1992018462A1 (en) * 1991-04-12 1992-10-29 Schering Corporation Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
DK0690843T3 (da) * 1993-03-25 2000-11-13 Upjohn Co Fornyl- eller cyanosubstituerede indolderivater med dopaninerg aktivitet
FR2704857B1 (fr) * 1993-05-07 1995-06-23 Adir Nouvelles benzodioxines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant.
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
FR2716680B1 (fr) * 1994-02-25 1996-04-05 Adir Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JPH07242543A (ja) * 1994-03-03 1995-09-19 Taiho Yakuhin Kogyo Kk 肝疾患治療剤
JPH07242655A (ja) * 1994-03-03 1995-09-19 Taiho Yakuhin Kogyo Kk １，４−ベンゾジオキサン誘導体
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2732969B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2734815B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2734814B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2734816B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CN1139584C (zh) 2004-02-25
CA2289599A1 (fr) 1998-11-26
ES2285775T3 (es) 2007-11-16
CY1106545T1 (el) 2012-01-25
HK1028028A1 (en) 2001-02-02
JP2002510290A (ja) 2002-04-02
US6602903B2 (en) 2003-08-05
NO995594D0 (no) 1999-11-15
DK0998471T3 (da) 2007-07-02
DE69837334D1 (de) 2007-04-26
CN1260789A (zh) 2000-07-19
ATE356814T1 (de) 2007-04-15
PL336857A1 (en) 2000-07-17
WO1998052935A1 (fr) 1998-11-26
NO324562B1 (no) 2007-11-19
PL197156B1 (pl) 2008-03-31
NO995594L (no) 2000-01-14
PT998471E (pt) 2007-06-05
EP0998471A1 (fr) 2000-05-10
US6313160B1 (en) 2001-11-06
AU741753B2 (en) 2001-12-06
EP0998471B1 (fr) 2007-03-14
HUP0003127A2 (hu) 2002-05-29
NZ500952A (en) 2002-03-01
US20020052400A1 (en) 2002-05-02
ZA984114B (en) 1998-11-24
AU7772398A (en) 1998-12-11
CA2289599C (fr) 2005-12-06
FR2763335A1 (fr) 1998-11-20
HUP0003127A3 (en) 2002-12-28
FR2763335B1 (fr) 2000-11-24
DE69837334T2 (de) 2008-01-10

Similar Documents

Publication Publication Date Title
BR9911771A (pt) Compostos cìclicos substituìdos, um processo para sua preparação e composições farmacêuticas que contêm os mesmos
BRPI0112986B8 (pt) compostos azabicíclicos, processo para a sua preparação, bem como composições farmacêuticas compreendendo os ditos compostos
DK671088D0 (da) Thiazolidindion-forbindelser, deres anvendelse til fremstilling af hypoglycaemiske og atherosclerose-modvirkende laegemidler og farmaceutiske praeparater indeholdende disse forbindelser
FI862210A0 (fi) Imidazoheterocykliska foereningar och foerfarande foer deras framstaellning.
BR9909565A (pt) Derivados bicìclicos do ácido hidroxâmico
FR2593504B1 (fr) Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
BR0011282A (pt) Derivados da purina, seu processo de preparo e composiçoes farmacêuticas que as contêm
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
ATE49592T1 (de) 6-sauerstoffhaltige-1,3,4,5tetrahydrobenz(cd)indole-4-amine.
FI844333L (fi) 11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
DE68926981D1 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
BR0002505A (pt) Derivados de 4-arilpiperidina para o tratamento de prurido
BR9801448A (pt) Compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos.
BR9907497A (pt) Compostos de imidazolina, um processo para seu preparo e compostos farmacêuticos contendo os mesmos
ATE73821T1 (de) Pyrrolidonderivate.
ZA984114B (en) Substituted heterocyclic compounds a process for the preparation thereof and pharmaceutical compositions containing them
BG92842A (bg) Метод за получаване на бета-карбонил-карбоксиамиди на 1,3-тиазолидини
ES2052526T3 (es) Derivados de pirimidina, su preparacion y medicamentos que contienen estos derivados.
SE8303913L (sv) Heterocykliska foreningar
BR9904951A (pt) Compostos cìclicos tendo uma cadeia cicloalquileno, processo para sua preparação e composições farmacêuticas contendo os mesmos
ATE47135T1 (de) Antikonvulsive mittel.
IT1197841B (it) Derivati pirido-benzotiazinici ad attivita&#39; antibatterica ed a lunga durata di azione
BR0111854A (pt) Derivados de podofilotoxina carbamato e tiocarbamato, seu processo de preparação e composições farmacêuticas que os contêm
EA200000261A3 (ru) Новые замещенные димерные соединения, способ их получения и содержащияся их фармацевтическая композиция
ATE38029T1 (de) Benz-trisubstituierte 2-aminotetraline.

Legal Events

Date Code Title Description
PC Transfer

Free format text: LES LABORATOIRES SERVIER (FR)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.