BR9810557A - Compostos derivados de tiofeno e benzotiofeno e utilização e composição correspondentes - Google Patents
Compostos derivados de tiofeno e benzotiofeno e utilização e composição correspondentesInfo
- Publication number
- BR9810557A BR9810557A BR9810557-4A BR9810557A BR9810557A BR 9810557 A BR9810557 A BR 9810557A BR 9810557 A BR9810557 A BR 9810557A BR 9810557 A BR9810557 A BR 9810557A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- thiophene
- composition
- benzothiophene
- compounds
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 5
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title abstract 4
- 229930192474 thiophene Natural products 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- -1 -OR ~ 12 ~ Chemical group 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Abstract
Patente de Invenção: <B>"COMPOSTOS DERIVADOS DE TIOFENO E BENZOTIOFENO E UTILIZAçãO E COMPOSIçãO CORRESPONDENTES"<D>. Compostos derivados de tiofeno e benzotiofeno e utilização e composição correspondentes; os compostos têm a fórmula (I) onde Z é -CO-CH(OR~ 6~)-, -C(NOR~ 7~)-; R~ 1~é: H, alquila C~ 1~-C~ 6~, halogênio ou -O-R~ 12~; R~ 2~ e R~ 3~ são H, alquila, halogênio, nitro ou -O-R~ 12~ ou ainda R~ 2~ e R~ 3~ juntos são -CR~ 8~=CR~ 9~-CR~ 10~=CR~ 11~-; R~ 4~ e R~ 5~ são H, alquila, halogênio, haloalquila, -OR~ 12~, nitro, -NR~ 13~R~ 14~; -COR~ 12~, -CO~ 2~R~ 12~, -SO~ 2~NR~ 13~R~ 14~, -SO~ 2~R~ 12~, -SR~ 12~, ciano, -CONR~ 13~R~ 14~, ou ainda R~ 4~e R~ 5~ juntos formam um anel benzeno; R~ 6~é: H, alquila, -CO~ 2~R~ 12~, -C(O)NR~ 13~R~ 14~, naftila ou fenila; R~ 7~é: H ou alquila; R~ 8~, R~ 9~, R~ 10~ e R~ 11~ são H, alquila, halogênio, -OR~ 12~, nitro, ciano, -NR~ 13~R~ 14~, -COR~ 12~, -CO~ 2~ R~ 12~, -SO~ 2~NR~ 13~R~ 14~, -SO~ 2~R~ 12~, -SR~ 12~, -CONR~ 13~R~ 14~; R~ 12~ é H, alquila C~ 1~-C~ 6~ ou fenila; e R~ 13~e R~ 14~ são H, alquila C~ 1~-C~ 6~ou fenila ou ainda R~ 13~ e R~ 14~um anel de 5 ou 6. Estes compostos são eficazes para o tratamento da ansiedade e da depressão.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009701517A ES2128266B1 (es) | 1997-07-08 | 1997-07-08 | Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes. |
| PCT/ES1998/000191 WO1999002516A1 (es) | 1997-07-08 | 1998-07-01 | Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810557A true BR9810557A (pt) | 2000-08-08 |
Family
ID=8299986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810557-4A BR9810557A (pt) | 1997-07-08 | 1998-07-01 | Compostos derivados de tiofeno e benzotiofeno e utilização e composição correspondentes |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6262056B1 (pt) |
| EP (1) | EP1008594B1 (pt) |
| JP (1) | JP2002511883A (pt) |
| KR (1) | KR20010021632A (pt) |
| CN (1) | CN1125821C (pt) |
| AT (1) | ATE261956T1 (pt) |
| AU (1) | AU735637B2 (pt) |
| BR (1) | BR9810557A (pt) |
| CA (1) | CA2295715A1 (pt) |
| DE (1) | DE69822478D1 (pt) |
| EA (1) | EA002687B1 (pt) |
| ES (1) | ES2128266B1 (pt) |
| HU (1) | HUP0002861A3 (pt) |
| IL (1) | IL133566A (pt) |
| IS (1) | IS5328A (pt) |
| NZ (1) | NZ502128A (pt) |
| OA (1) | OA11274A (pt) |
| PL (1) | PL337930A1 (pt) |
| SK (1) | SK272000A3 (pt) |
| TR (1) | TR200000058T2 (pt) |
| WO (1) | WO1999002516A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001007431A2 (en) * | 1999-07-21 | 2001-02-01 | Eli Lilly And Company | Benzothiophene derivatives |
| ATE261959T1 (de) | 1999-12-30 | 2004-04-15 | Lundbeck & Co As H | Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung |
| DE10043659A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | Arylpiperazinderivate |
| ES2188344B1 (es) * | 2000-11-29 | 2004-09-16 | Laboratorios Vita, S.A. | Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. |
| JP2006516977A (ja) | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ，インコーポレイテッド | 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法 |
| WO2004082686A2 (en) * | 2003-03-13 | 2004-09-30 | Dynogen Pharmaceuticals, Inc. | Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| ES2379848T3 (es) * | 2007-05-14 | 2012-05-04 | Sk Biopharmaceuticals Co., Ltd. | Compuesto arilpiperazina arilalcanoil carbomoiloxi novedoso, composiciones farmacéuticas que comprenden el compuesto y método para tratar el dolor, ansiedad y depresión al administrar el compuesto |
| CN101613347B (zh) * | 2008-06-23 | 2012-07-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 胺类化合物及其医药用途 |
| CN101619056B (zh) | 2008-07-02 | 2013-07-17 | 石药集团中奇制药技术（石家庄）有限公司 | 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用 |
| EP2539706B1 (en) * | 2010-02-24 | 2015-03-04 | Research Triangle Institute | Arylpiperazine opioid receptor antagonists |
| EP3083589B1 (en) | 2013-12-20 | 2019-12-18 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
| WO2021152113A1 (en) | 2020-01-31 | 2021-08-05 | Bayer Aktiengesellschaft | Substituted 2,3-benzodiazepines derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979507A (en) * | 1959-03-26 | 1961-04-11 | Paul Adriaan J Janssen | 1-(2-thenoyl) alkyl-4-arylpiperazines |
| US3002976A (en) * | 1959-10-12 | 1961-10-03 | Paul A J Janssen | 1-(2-thienyl)-omega-(4-arylpiperazine)alkanols |
| GB1096341A (en) * | 1965-03-09 | 1967-12-29 | Mauvernay Roland Yves | Novel derivatives of the phenyl-piperazine series and process for their preparation |
| US4515793A (en) * | 1983-07-27 | 1985-05-07 | Edna Mcconnell Clark Foundation | Phenylpiperazines which are useful in the treatment of schistosomiasis |
| WO1993003025A1 (en) * | 1991-08-09 | 1993-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Thiophene compound |
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| US5632898A (en) * | 1996-08-13 | 1997-05-27 | Isis Pharmaceuticals, Inc. | Method for removing unreacted electrophiles from a reaction mixture |
-
1997
- 1997-07-08 ES ES009701517A patent/ES2128266B1/es not_active Expired - Fee Related
-
1998
- 1998-07-01 NZ NZ502128A patent/NZ502128A/en unknown
- 1998-07-01 EP EP98930807A patent/EP1008594B1/en not_active Expired - Lifetime
- 1998-07-01 IL IL13356698A patent/IL133566A/xx not_active IP Right Cessation
- 1998-07-01 AU AU81113/98A patent/AU735637B2/en not_active Ceased
- 1998-07-01 SK SK27-2000A patent/SK272000A3/sk unknown
- 1998-07-01 PL PL98337930A patent/PL337930A1/xx unknown
- 1998-07-01 AT AT98930807T patent/ATE261956T1/de not_active IP Right Cessation
- 1998-07-01 EA EA200000101A patent/EA002687B1/ru not_active IP Right Cessation
- 1998-07-01 HU HU0002861A patent/HUP0002861A3/hu unknown
- 1998-07-01 TR TR2000/00058T patent/TR200000058T2/xx unknown
- 1998-07-01 DE DE69822478T patent/DE69822478D1/de not_active Expired - Lifetime
- 1998-07-01 KR KR1020007000190A patent/KR20010021632A/ko not_active Ceased
- 1998-07-01 BR BR9810557-4A patent/BR9810557A/pt not_active IP Right Cessation
- 1998-07-01 CN CN98807490A patent/CN1125821C/zh not_active Expired - Fee Related
- 1998-07-01 WO PCT/ES1998/000191 patent/WO1999002516A1/es not_active Ceased
- 1998-07-01 CA CA002295715A patent/CA2295715A1/en not_active Abandoned
- 1998-07-01 JP JP50819399A patent/JP2002511883A/ja active Pending
-
1999
- 1999-12-29 IS IS5328A patent/IS5328A/is unknown
-
2000
- 2000-01-06 OA OA1200000002A patent/OA11274A/en unknown
- 2000-01-10 US US09/480,120 patent/US6262056B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002511883A (ja) | 2002-04-16 |
| AU735637B2 (en) | 2001-07-12 |
| KR20010021632A (ko) | 2001-03-15 |
| EA200000101A1 (ru) | 2000-08-28 |
| IL133566A0 (en) | 2001-04-30 |
| SK272000A3 (en) | 2000-07-11 |
| CA2295715A1 (en) | 1999-01-21 |
| DE69822478D1 (de) | 2004-04-22 |
| PL337930A1 (en) | 2000-09-11 |
| IL133566A (en) | 2003-10-31 |
| EP1008594B1 (en) | 2004-03-17 |
| ES2128266B1 (es) | 2000-01-16 |
| IS5328A (is) | 1999-12-29 |
| OA11274A (en) | 2003-07-29 |
| CN1125821C (zh) | 2003-10-29 |
| CN1265106A (zh) | 2000-08-30 |
| HUP0002861A3 (en) | 2001-09-28 |
| NZ502128A (en) | 2001-09-28 |
| EP1008594A1 (en) | 2000-06-14 |
| ATE261956T1 (de) | 2004-04-15 |
| AU8111398A (en) | 1999-02-08 |
| US6262056B1 (en) | 2001-07-17 |
| TR200000058T2 (tr) | 2000-09-21 |
| ES2128266A1 (es) | 1999-05-01 |
| EA002687B1 (ru) | 2002-08-29 |
| HUP0002861A2 (hu) | 2001-08-28 |
| WO1999002516A1 (es) | 1999-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: LABORATORIOS VITA, S.A. (ES) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007. |