BR9812837A - Processo para fazer um composto, e, composto - Google Patents

Processo para fazer um composto, e, composto

Info

Publication number
BR9812837A
BR9812837A BR9812837-0A BR9812837A BR9812837A BR 9812837 A BR9812837 A BR 9812837A BR 9812837 A BR9812837 A BR 9812837A BR 9812837 A BR9812837 A BR 9812837A
Authority
BR
Brazil
Prior art keywords
compound
making
cyclooxygenase
usable
formula
Prior art date
Application number
BR9812837-0A
Other languages
English (en)
Other versions
BR9812837B1 (pt
Inventor
Ian W Davies
Linda Gerena
Michael Journet
Robert D Larsen
Philip J Pye
Kai Rossen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806419.9A external-priority patent/GB9806419D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BR9812837A publication Critical patent/BR9812837A/pt
Publication of BR9812837B1 publication Critical patent/BR9812837B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA FAZER UM COMPOSTO, E, COMPOSTO" A invenção engloba um processo para fazer compostos de fórmula (I) utilizáveis no tratamento de doenças mediadas por ciclo-oxigenase-2.
BRPI9812837-0A 1997-09-25 1998-09-22 processo para fazer um composto diaril-piridina. BR9812837B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6068097P 1997-09-25 1997-09-25
GBGB9806419.9A GB9806419D0 (en) 1998-03-25 1998-03-25 Process for making diaryl pyridines useful as cox-2 inhibitors
PCT/US1998/019788 WO1999015503A2 (en) 1997-09-25 1998-09-22 Process for making diaryl pyridines useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
BR9812837A true BR9812837A (pt) 2000-08-08
BR9812837B1 BR9812837B1 (pt) 2010-08-24

Family

ID=26313354

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9812837-0A BR9812837B1 (pt) 1997-09-25 1998-09-22 processo para fazer um composto diaril-piridina.

Country Status (14)

Country Link
EP (1) EP1023266B1 (pt)
JP (2) JP3325263B2 (pt)
CN (1) CN1134415C (pt)
AR (1) AR015938A1 (pt)
AT (1) ATE230726T1 (pt)
AU (1) AU9500298A (pt)
BR (1) BR9812837B1 (pt)
CZ (1) CZ298850B6 (pt)
DE (1) DE69810652T2 (pt)
DK (1) DK1023266T3 (pt)
EA (1) EA002427B1 (pt)
ES (1) ES2189251T3 (pt)
SK (1) SK283811B6 (pt)
WO (1) WO1999015503A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143981A0 (en) * 1999-01-14 2002-04-21 Lonza Ag 1-(6-methylpyridine-3-yl)-2-[4-(methylsulfonyl) phenyl) ethanone and method for its preparation
US7141673B1 (en) 1999-01-14 2006-11-28 Lonza Ag 1-(6-methylpyridine-3-yl)-2-[4-(methylsulphonyl) phenyl] ethanone and method for its preparation
JP3032980B1 (ja) 1999-06-14 2000-04-17 三協化学株式会社 ２―ピリジルピリジン誘導体の製造方法
US6566527B1 (en) * 1999-07-27 2003-05-20 Merck & Co., Inc. Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone
WO2001007410A1 (en) * 1999-07-27 2001-02-01 Lonza Ag Process for preparing 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulphonyl) phenyl] ethanone
JP2001115963A (ja) 1999-10-13 2001-04-27 Daikin Ind Ltd 圧縮機
IT1315244B1 (it) * 1999-10-15 2003-02-03 Zambon Spa Processo per la preparazione di intermedi utili nella sintesi didiarilpiridine
IT1315243B1 (it) * 1999-10-15 2003-02-03 Zambon Spa Processo di ossidazione per la preparazione di intermedi utili nellasintesi di diarilpiridine
JP2001261646A (ja) * 2000-03-17 2001-09-26 Sankio Chemical Co Ltd ピリジン誘導体の製造法
JP2001261647A (ja) * 2000-03-22 2001-09-26 Sankio Chemical Co Ltd ピリジン誘導体の製造方法
EP1303265B1 (en) 2000-07-20 2007-07-11 Lauras AS Use of cox-2 inhibitors as immunostimulants in the treatment of hiv or aids
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
ITMI20012692A1 (it) * 2001-12-19 2003-06-19 Zambon Spa Processo di ossidazione per la preparazione di intermedi utili nella sintesi di diarilpiridine
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
WO2011158250A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
BR112013012008B1 (pt) * 2010-11-15 2021-10-13 Virdev Intermediates Pvt. Ltd Processo para o inibidor seletivo da ciclo-oxigenase-2
ITMI20110362A1 (it) 2011-03-09 2012-09-10 F I S Fabbrica Italiana Sint P A Procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib.
CN102276517B (zh) * 2011-06-29 2012-11-28 孙光辉 二芳基吡啶类药物的合成方法
ITMI20111455A1 (it) 2011-07-29 2013-01-30 Italiana Sint Spa Nuovo procedimento per la preparazione di 1-(6-metilpiridin-3-il)-2-[4-(metilsolfonil)fenil]etanone, un intermedio dell'etoricoxib.
WO2013065064A1 (en) * 2011-10-31 2013-05-10 Sequent Scientific Limited A process for preparation of l-(6-methylpyridin-3-yl)-2-[4-(meth.ylsulfonyi)phenyl]ethanone field of invention
CN103204803A (zh) * 2012-01-13 2013-07-17 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 用于合成依托考昔的方法
ITMI20121947A1 (it) * 2012-11-15 2014-05-16 Erregierre Spa Processo di sintesi di un intermedio nella produzione di etoricoxib
ITVI20130014A1 (it) 2013-01-22 2014-07-23 Italiana Sint Spa Procedimento molto efficiente per preparare un intermedio di etoricoxib
CN104418799A (zh) * 2013-09-03 2015-03-18 天津药物研究院 一种依托考昔的晶型及其制备方法和应用
WO2015036550A1 (en) * 2013-09-13 2015-03-19 Synthon B.V. Process for making etoricoxib
CN104529798B (zh) * 2014-12-10 2016-03-30 齐鲁天和惠世制药有限公司 一种依托考昔中间体3-氨基-2-氯丙烯醛的制备方法
JP6696507B2 (ja) * 2015-07-21 2020-05-20 住友化学株式会社 ４−（トリフルオロメチルスルホニル）フェノール化合物の製造方法
CN108689917A (zh) * 2017-04-08 2018-10-23 深圳市华先医药科技有限公司 一种依托考昔中间体连续流生产工艺
CN109810052B (zh) * 2017-11-20 2020-06-23 新发药业有限公司 一种高选择性的阿帕替尼的简便制备方法
CN112300061B (zh) * 2020-10-06 2022-02-18 大连理工大学 一种含氮杂环二芳酮化合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277103A (en) * 1961-06-29 1966-10-04 Du Pont beta-amino-alpha-cyanoacroleins and their preparation
US4242515A (en) * 1979-03-28 1980-12-30 American Cyanamid Company Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines
CH660733A5 (de) * 1981-09-29 1987-06-15 Lonza Ag Verfahren zur herstellung von 3-picolin.
DE3634259A1 (de) * 1986-10-08 1988-04-21 Basf Ag Verfahren zur herstellung von substituierten pyridinen
EP0548559A1 (en) * 1991-12-27 1993-06-30 American Cyanamid Company Process for the preparation of dialkyl pyridine -2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
BR9607035A (pt) 1995-02-13 1997-11-04 Searle & Co Isoxazois substituidos para o tratamento de inflamação
TW492959B (en) 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors

Also Published As

Publication number Publication date
ATE230726T1 (de) 2003-01-15
DE69810652T2 (de) 2003-10-09
EA200000358A1 (ru) 2000-10-30
JP2003026687A (ja) 2003-01-29
SK283811B6 (sk) 2004-02-03
EA002427B1 (ru) 2002-04-25
BR9812837B1 (pt) 2010-08-24
SK4222000A3 (en) 2000-10-09
CN1134415C (zh) 2004-01-14
CZ20001088A3 (cs) 2000-09-13
CZ298850B6 (cs) 2008-02-27
AR015938A1 (es) 2001-05-30
ES2189251T3 (es) 2003-07-01
HK1029343A1 (en) 2001-03-30
EP1023266A2 (en) 2000-08-02
JP3325263B2 (ja) 2002-09-17
WO1999015503A2 (en) 1999-04-01
DK1023266T3 (da) 2003-02-24
JP4157325B2 (ja) 2008-10-01
EP1023266B1 (en) 2003-01-08
AU9500298A (en) 1999-04-12
DE69810652D1 (de) 2003-02-13
JP2001517654A (ja) 2001-10-09
CN1278795A (zh) 2001-01-03
WO1999015503A3 (en) 1999-05-20

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERACAO DA INT.CL.8:C07D 213/127;C07D 213/12;C07D 213/22

Ipc: C07D 213/127 (2008.04), C07D 213/12 (2008.04), C07

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 15A, 16A E 17A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.