BR9814015A - Processo para preparação de produtos sólidos instantaneamente solúveis para uso farmacêutico, ditos produtos, método de prevenção e tratamento - Google Patents
Processo para preparação de produtos sólidos instantaneamente solúveis para uso farmacêutico, ditos produtos, método de prevenção e tratamentoInfo
- Publication number
- BR9814015A BR9814015A BR9814015-9A BR9814015A BR9814015A BR 9814015 A BR9814015 A BR 9814015A BR 9814015 A BR9814015 A BR 9814015A BR 9814015 A BR9814015 A BR 9814015A
- Authority
- BR
- Brazil
- Prior art keywords
- products
- cyclodextrin
- prevention
- treatment
- pharmaceutical use
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000000047 product Substances 0.000 title abstract 2
- 239000012265 solid product Substances 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"PROCESSO PARA PREPARAçãO DE PRODUTOS SóLIDOS INSTANTANEAMENTE SOLúVEIS PARA USO FARMACêUTICO, DITOS PRODUTOS, MéTODO DE PREVENçãO E TRATAMENTO". A presente invenção refere-se a composições farmacêuticas sólidas solúveis em água e suas soluções em solventes aquosos, ditas composições contendo a). como ingrediente ativo um taxóide amorfo finamente disperso preferivelmente liofilizado e com extensa área superficial, tal como paclitaxel ou docetaxel, seus sais e seus hidratos ou solvatos polimórficos, tal como solvatos formados com etanol e b). acetil-y-ciclodextrina ou hidroxi-propil-ß-ciclodextrina (ciclodextrina) amorfa finamente dispersa, preferivelmente liofilizada e com externa área superficial, por meio do que a relação de peso de dito taxóide: dita ciclodextrina varia entre 1 : 25 e 1 : 400; c). e opcionalmente outros materiais auxiliares solúveis em água comuns em fármacos para fins parenterais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701945A HUP9701945A3 (en) | 1997-11-10 | 1997-11-10 | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
| PCT/HU1998/000097 WO1999024073A1 (en) | 1997-11-10 | 1998-11-09 | Pharmaceutical compositions containing cyclodextrins and taxoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9814015A true BR9814015A (pt) | 2000-09-26 |
Family
ID=89995733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9814015-9A BR9814015A (pt) | 1997-11-10 | 1998-11-09 | Processo para preparação de produtos sólidos instantaneamente solúveis para uso farmacêutico, ditos produtos, método de prevenção e tratamento |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7671042B2 (pt) |
| EP (1) | EP1059942B1 (pt) |
| JP (1) | JP3656550B2 (pt) |
| KR (1) | KR100607391B1 (pt) |
| CN (1) | CN1222321C (pt) |
| AR (1) | AR015482A1 (pt) |
| AT (1) | ATE387916T1 (pt) |
| AU (1) | AU742036B2 (pt) |
| BR (1) | BR9814015A (pt) |
| CA (1) | CA2309326C (pt) |
| DE (1) | DE69839224T2 (pt) |
| EA (1) | EA002776B1 (pt) |
| HU (1) | HUP9701945A3 (pt) |
| IL (1) | IL135990A0 (pt) |
| NO (1) | NO329382B1 (pt) |
| NZ (1) | NZ504098A (pt) |
| PL (1) | PL199652B1 (pt) |
| WO (1) | WO1999024073A1 (pt) |
| ZA (1) | ZA989779B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020300A1 (es) | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| WO2003015828A1 (en) * | 2001-08-20 | 2003-02-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Parenteral formulations of 1-(5-tert-butyl-2-p-tolyl-2h-pryrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea and a cyclodextrin |
| CN100384865C (zh) * | 2001-11-02 | 2008-04-30 | 嵌入治疗公司 | 用于rna干扰的治疗用途的方法及组合物 |
| US20050255164A1 (en) * | 2002-08-15 | 2005-11-17 | Yunging Liu | Solid nano pharmaceutical formulation and preparation method thereof |
| AR054215A1 (es) | 2006-01-20 | 2007-06-13 | Eriochem Sa | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
| CN101020059B (zh) * | 2006-02-15 | 2011-01-05 | 中国科学院上海药物研究所 | 一种含多烯紫杉醇类物质的药物组合物及其制备方法 |
| KR100917809B1 (ko) * | 2006-05-22 | 2009-09-18 | 에스케이케미칼주식회사 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
| KR100917810B1 (ko) * | 2006-06-02 | 2009-09-18 | 에스케이케미칼주식회사 | 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물 |
| WO2007142440A1 (en) * | 2006-06-02 | 2007-12-13 | Sk Chemicals Co., Ltd. | Stable pharmaceutical composition containing paclitaxel and a method of manufacturing the same |
| CN100411688C (zh) * | 2006-09-12 | 2008-08-20 | 南京师范大学 | 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法 |
| CN100486645C (zh) | 2006-09-12 | 2009-05-13 | 南京师范大学 | 含有环糊精紫杉醇包合物的药物组合物及其制备方法 |
| WO2008092084A2 (en) | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| US20080262078A1 (en) * | 2007-04-20 | 2008-10-23 | Namdeo Alok B | Pharmaceutical Compositions |
| WO2009002425A2 (en) * | 2007-06-22 | 2008-12-31 | Scidose Llc | Solubilized formulation of docetaxel without tween 80 |
| US20090087460A1 (en) * | 2007-10-02 | 2009-04-02 | Hamamatsu Photonics K.K. | Solid composition, microparticles, microparticle dispersion liquid, and manufacturing methods for these |
| AR063111A1 (es) | 2007-10-03 | 2008-12-30 | Eriochem Sa | Una formulacion farmaceutica de taxano |
| KR101478779B1 (ko) * | 2007-11-22 | 2015-01-05 | 에스케이케미칼주식회사 | 재수화시간이 향상된 택산 유도체 함유 동결건조 조성물 및이의 제조방법 |
| KR101502533B1 (ko) * | 2007-11-22 | 2015-03-13 | 에스케이케미칼주식회사 | 우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법 |
| EP2106786A1 (de) * | 2008-04-04 | 2009-10-07 | Roewer, Norbert, Univ.-Prof. Dr. med. | Pharmazeutische Zubereitung mit permethyliertem Cyclodextrin |
| US8912228B2 (en) | 2009-10-19 | 2014-12-16 | Scidose Llc | Docetaxel formulations with lipoic acid |
| KR20120130740A (ko) * | 2011-05-23 | 2012-12-03 | 에스케이케미칼주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
| US11406595B2 (en) * | 2012-05-21 | 2022-08-09 | University Of Maryland, College Park | Highly stable colloid from aqueous solutions of small organic molecules |
| WO2014075935A1 (de) | 2012-11-15 | 2014-05-22 | Sapiotec Gmbh | Delphinidinkomplex als antiphlogistischer oder immunsuppressiver wirkstoff |
| CN104936601A (zh) | 2012-12-11 | 2015-09-23 | 赛博尔泰克股份公司 | 用于对抗黑色素瘤细胞的飞燕草素 |
| CN105823810A (zh) * | 2016-01-04 | 2016-08-03 | 杭州电子科技大学 | 紫杉醇化疗效果检测装置及检测方法 |
| KR101829705B1 (ko) * | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성이 향상된 주사용 조성물 |
| KR102262743B1 (ko) | 2017-07-07 | 2021-06-09 | 에이치케이이노엔 주식회사 | 주사용 조성물 |
| CN110755371B (zh) | 2018-07-25 | 2021-08-31 | 比卡生物科技（广州）有限公司 | 一种注射用多西他赛组合物及其制备方法 |
| JP7802829B2 (ja) * | 2021-05-26 | 2026-01-20 | デウン ファーマシューティカル カンパニー リミテッド | １－（５－（２，４－ジフルオロフェニル）－１－（（３－フルオロフェニル）スルホニル）－４－メトキシ－１ｈ－ピロール－３－イル）－ｎ－メチルメタンアミンを含む新規な注射用製剤 |
| CN115960834B (zh) * | 2023-03-07 | 2023-06-09 | 浙江省肿瘤医院 | 一种pd-1/ptx联合pd-1耐药模型建立的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| JPH06157330A (ja) * | 1992-11-27 | 1994-06-03 | Ensuiko Sugar Refining Co Ltd | タキソールのサイクロデキストリン包接物，その製造法と用途 |
| JPH0753396A (ja) * | 1993-08-19 | 1995-02-28 | Ensuiko Sugar Refining Co Ltd | タキソールのサイクロデキストリン包接物，その製造法および用途 |
| HU213200B (en) * | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
| DE4414138A1 (de) * | 1994-04-22 | 1995-10-26 | Consortium Elektrochem Ind | Acylierte gamma-Cyclodextrine |
| HUT73844A (en) * | 1994-11-11 | 1996-09-30 | Chinoin Gyogyszer Es Vegyeszet | New taxol complexes and pharmaceutical compositions containing them |
| CA2163837C (en) * | 1994-12-13 | 1999-07-20 | Robert K. Perrone | Crystalline paclitaxel hydrates |
| PL368945A1 (en) * | 2001-11-30 | 2005-04-04 | Bristol-Myers Squibb Company | Paclitaxel solvates |
-
1997
- 1997-11-10 HU HU9701945A patent/HUP9701945A3/hu unknown
-
1998
- 1998-10-27 ZA ZA989779A patent/ZA989779B/xx unknown
- 1998-11-06 AR ARP980105607A patent/AR015482A1/es unknown
- 1998-11-09 KR KR1020007005076A patent/KR100607391B1/ko not_active Expired - Fee Related
- 1998-11-09 AU AU12538/99A patent/AU742036B2/en not_active Ceased
- 1998-11-09 CA CA2309326A patent/CA2309326C/en not_active Expired - Fee Related
- 1998-11-09 AT AT98955818T patent/ATE387916T1/de active
- 1998-11-09 WO PCT/HU1998/000097 patent/WO1999024073A1/en not_active Ceased
- 1998-11-09 CN CNB988110105A patent/CN1222321C/zh not_active Expired - Fee Related
- 1998-11-09 EP EP98955818A patent/EP1059942B1/en not_active Expired - Lifetime
- 1998-11-09 JP JP2000520158A patent/JP3656550B2/ja not_active Expired - Fee Related
- 1998-11-09 PL PL340505A patent/PL199652B1/pl not_active IP Right Cessation
- 1998-11-09 EA EA200000494A patent/EA002776B1/ru not_active IP Right Cessation
- 1998-11-09 IL IL13599098A patent/IL135990A0/xx unknown
- 1998-11-09 BR BR9814015-9A patent/BR9814015A/pt not_active Application Discontinuation
- 1998-11-09 DE DE69839224T patent/DE69839224T2/de not_active Expired - Lifetime
- 1998-11-09 NZ NZ504098A patent/NZ504098A/xx not_active IP Right Cessation
-
2000
- 2000-04-27 NO NO20002165A patent/NO329382B1/no not_active IP Right Cessation
-
2006
- 2006-10-04 US US11/542,797 patent/US7671042B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA989779B (en) | 1999-04-28 |
| HUP9701945A3 (en) | 2000-04-28 |
| JP3656550B2 (ja) | 2005-06-08 |
| CA2309326C (en) | 2010-12-21 |
| CA2309326A1 (en) | 1999-05-20 |
| CN1222321C (zh) | 2005-10-12 |
| US20070087999A1 (en) | 2007-04-19 |
| WO1999024073B1 (en) | 1999-07-08 |
| EP1059942A2 (en) | 2000-12-20 |
| KR100607391B1 (ko) | 2006-08-02 |
| AU1253899A (en) | 1999-05-31 |
| EA200000494A1 (ru) | 2000-10-30 |
| PL199652B1 (pl) | 2008-10-31 |
| NZ504098A (en) | 2003-06-30 |
| HUP9701945A1 (hu) | 1999-09-28 |
| CN1281373A (zh) | 2001-01-24 |
| JP2001522816A (ja) | 2001-11-20 |
| WO1999024073A1 (en) | 1999-05-20 |
| US7671042B2 (en) | 2010-03-02 |
| DE69839224T2 (de) | 2009-04-16 |
| EP1059942B1 (en) | 2008-03-05 |
| AR015482A1 (es) | 2001-05-02 |
| IL135990A0 (en) | 2001-05-20 |
| NO20002165L (no) | 2000-07-07 |
| DE69839224D1 (de) | 2008-04-17 |
| KR20010031967A (ko) | 2001-04-16 |
| HU9701945D0 (en) | 1998-01-28 |
| AU742036B2 (en) | 2001-12-13 |
| NO20002165D0 (no) | 2000-04-27 |
| NO329382B1 (no) | 2010-10-04 |
| EA002776B1 (ru) | 2002-08-29 |
| PL340505A1 (en) | 2001-02-12 |
| ATE387916T1 (de) | 2008-03-15 |
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