BR9902014A - Compostos peptìdicos que são análogos do peptìdio-1 (7-37) semelhante ao glucagon, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos. - Google Patents

Compostos peptìdicos que são análogos do peptìdio-1 (7-37) semelhante ao glucagon, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos.

Info

Publication number
BR9902014A
BR9902014A BR9902014-9A BR9902014A BR9902014A BR 9902014 A BR9902014 A BR 9902014A BR 9902014 A BR9902014 A BR 9902014A BR 9902014 A BR9902014 A BR 9902014A
Authority
BR
Brazil
Prior art keywords
peptide
group
gly
glucagon
pharmaceutical compositions
Prior art date
Application number
BR9902014-9A
Other languages
English (en)
Inventor
Bernard Calas
Gerard Grassy
Alain Chavanieu
Cyril Sarrauste De Menthiere
Pierre Renard
Bruno Pfeiffer
Dominique Manechez
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BR9902014A publication Critical patent/BR9902014A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS PEPTìDEOS QUE SãO ANáLOGOA DO PEPTìDEO-1 (7-37) SEMELHANTE AO GLUCAGON, PROCESSO PARA A PREPARAçãO DOS MESMOS E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS"<D>. Compostos peptídeos de fórmula (I): Z1-X~ 1~- X2-X3- Gly -Thr - Phe-Thr -Ser-X~ 4~-X~ 5~-Ser-X~ 6~-X~ 7~-X8-Glu-Gly-Gln-Ala-X~ 9~-Lys-X10-X~ 11~-X~ 12~-Ala_X13-X~ 14~-Val-Lys-Gly-X~ 15~-Gly-Z2 onde: .Z~ 1~, substituinte do grupo amino terminal, representa um átomo de hidrogênio ou um grupo alquila ou acila, ou um grupo arilcarbonila, heteroarilcarbonila, arialquicaronila, heteroarilcarbonila, ariloxicarbonila, arilalcoxicarbonila ou alcoxicarbonila, cada um deles sendo opcionalmente substituído, . Z2, substituinte do grupo carbonila terminal, representa um grupo hidróxi, um grupo alcóxi ou um grupo amino opcionalmente substituído, . Cada um de X1a X~ 14~ representa um resíduo de aminoácido tendo a configuração D ou L como definido no relatório descritivo, .X~ 15~representa uma ligação ou um resíduo arginina (Arg). Medicamentos.
BR9902014-9A 1998-04-10 1999-03-15 Compostos peptìdicos que são análogos do peptìdio-1 (7-37) semelhante ao glucagon, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos. BR9902014A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804559A FR2777283B1 (fr) 1998-04-10 1998-04-10 Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR9902014A true BR9902014A (pt) 2000-05-02

Family

ID=9525150

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9902014-9A BR9902014A (pt) 1998-04-10 1999-03-15 Compostos peptìdicos que são análogos do peptìdio-1 (7-37) semelhante ao glucagon, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos.

Country Status (18)

Country Link
US (1) US6620910B1 (pt)
EP (1) EP0955314B1 (pt)
JP (1) JP3787242B2 (pt)
CN (1) CN1305897C (pt)
AT (1) ATE255596T1 (pt)
AU (1) AU761652B2 (pt)
BR (1) BR9902014A (pt)
CA (1) CA2263059A1 (pt)
DE (1) DE69913242T2 (pt)
DK (1) DK0955314T3 (pt)
ES (1) ES2212485T3 (pt)
FR (1) FR2777283B1 (pt)
HU (1) HUP9900604A3 (pt)
NO (1) NO323137B1 (pt)
NZ (1) NZ334379A (pt)
PL (1) PL331960A1 (pt)
PT (1) PT955314E (pt)
ZA (1) ZA992035B (pt)

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Also Published As

Publication number Publication date
HUP9900604A2 (hu) 1999-09-28
HU9900604D0 (en) 1999-05-28
ES2212485T3 (es) 2004-07-16
CN1232038A (zh) 1999-10-20
JPH11310597A (ja) 1999-11-09
EP0955314A3 (fr) 2000-03-29
CN1305897C (zh) 2007-03-21
NO991199L (no) 1999-10-11
PT955314E (pt) 2004-03-31
FR2777283A1 (fr) 1999-10-15
EP0955314A2 (fr) 1999-11-10
DE69913242D1 (de) 2004-01-15
NZ334379A (en) 1999-10-28
ZA992035B (en) 1999-09-27
ATE255596T1 (de) 2003-12-15
PL331960A1 (en) 1999-10-11
DK0955314T3 (da) 2004-04-13
AU761652B2 (en) 2003-06-05
DE69913242T2 (de) 2004-09-09
JP3787242B2 (ja) 2006-06-21
NO991199D0 (no) 1999-03-11
EP0955314B1 (fr) 2003-12-03
US6620910B1 (en) 2003-09-16
HK1022320A1 (en) 2000-08-04
NO323137B1 (no) 2007-01-08
FR2777283B1 (fr) 2000-11-24
AU2368899A (en) 1999-10-21
HUP9900604A3 (en) 2001-01-29
CA2263059A1 (fr) 1999-10-10

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