ATE255596T1 - Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number: ATE255596T1
Authority: AT; Austria
Prior art keywords: peptide; glucagone; preparation; pharmaceutical compositions; heteroarylcarbonyl
Prior art date: 1998-04-10

Application number

AT99400613T

Other languages

English (en)

Inventor

Bernard Calas

Gerard Grassy

Alain Chavanieu

De Menthiere Cyril Sarrauste

Pierre Renard

Bruno Pfeiffer

Dominique Manechez

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-10

Filing date

1999-03-12

Publication date

2003-12-15

1999-03-12 Application filed by Servier Lab filed Critical Servier Lab

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255596T1 publication Critical patent/ATE255596T1/de

Links

OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 title 1
101710176384 Peptide 1 Proteins 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT99400613T 1998-04-10 1999-03-12 Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen ATE255596T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9804559A FR2777283B1 (fr)	1998-04-10	1998-04-10	Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE255596T1 true ATE255596T1 (de)	2003-12-15

Family

ID=9525150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99400613T ATE255596T1 (de)	1998-04-10	1999-03-12	Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen

Country Status (18)

Country	Link
US (1)	US6620910B1 (de)
EP (1)	EP0955314B1 (de)
JP (1)	JP3787242B2 (de)
CN (1)	CN1305897C (de)
AT (1)	ATE255596T1 (de)
AU (1)	AU761652B2 (de)
BR (1)	BR9902014A (de)
CA (1)	CA2263059A1 (de)
DE (1)	DE69913242T2 (de)
DK (1)	DK0955314T3 (de)
ES (1)	ES2212485T3 (de)
FR (1)	FR2777283B1 (de)
HU (1)	HUP9900604A3 (de)
NO (1)	NO323137B1 (de)
NZ (1)	NZ334379A (de)
PL (1)	PL331960A1 (de)
PT (1)	PT955314E (de)
ZA (1)	ZA992035B (de)

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JP2007536214A (ja)	2003-12-16	2007-12-13	ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス	Ｇｌｐ−１類似体
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JP2008524331A (ja)	2004-12-21	2008-07-10	武田薬品工業株式会社	ジペプチジルペプチダーゼ阻害剤
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TWI428346B (zh)	2006-12-13	2014-03-01	Imp Innovations Ltd	新穎化合物及其等對進食行為影響
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
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JP2011500850A (ja) *	2007-10-24	2011-01-06	マンカインドコーポレイション	Ｇｌｐ−１による副作用を防止する方法
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TWI614024B (zh)	2008-08-11	2018-02-11	曼凱公司	超快起作用胰島素之用途
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1998
- 1998-04-10 FR FR9804559A patent/FR2777283B1/fr not_active Expired - Fee Related
1999
- 1999-02-25 NZ NZ334379A patent/NZ334379A/en unknown
- 1999-03-10 CA CA002263059A patent/CA2263059A1/fr not_active Abandoned
- 1999-03-11 NO NO19991199A patent/NO323137B1/no unknown
- 1999-03-12 AT AT99400613T patent/ATE255596T1/de not_active IP Right Cessation
- 1999-03-12 JP JP06691799A patent/JP3787242B2/ja not_active Expired - Fee Related
- 1999-03-12 PT PT99400613T patent/PT955314E/pt unknown
- 1999-03-12 DE DE69913242T patent/DE69913242T2/de not_active Expired - Fee Related
- 1999-03-12 EP EP99400613A patent/EP0955314B1/de not_active Expired - Lifetime
- 1999-03-12 PL PL99331960A patent/PL331960A1/xx not_active IP Right Cessation
- 1999-03-12 ZA ZA9902035A patent/ZA992035B/xx unknown
- 1999-03-12 DK DK99400613T patent/DK0955314T3/da active
- 1999-03-12 HU HU9900604A patent/HUP9900604A3/hu unknown
- 1999-03-12 ES ES99400613T patent/ES2212485T3/es not_active Expired - Lifetime
- 1999-03-15 BR BR9902014-9A patent/BR9902014A/pt not_active Application Discontinuation
- 1999-03-15 US US09/268,578 patent/US6620910B1/en not_active Expired - Fee Related
- 1999-03-15 CN CNB991039874A patent/CN1305897C/zh not_active Expired - Fee Related
- 1999-04-09 AU AU23688/99A patent/AU761652B2/en not_active Ceased

Also Published As

Publication number	Publication date
HUP9900604A2 (hu)	1999-09-28
HU9900604D0 (en)	1999-05-28
ES2212485T3 (es)	2004-07-16
CN1232038A (zh)	1999-10-20
JPH11310597A (ja)	1999-11-09
EP0955314A3 (de)	2000-03-29
CN1305897C (zh)	2007-03-21
NO991199L (no)	1999-10-11
PT955314E (pt)	2004-03-31
FR2777283A1 (fr)	1999-10-15
EP0955314A2 (de)	1999-11-10
DE69913242D1 (de)	2004-01-15
NZ334379A (en)	1999-10-28
ZA992035B (en)	1999-09-27
BR9902014A (pt)	2000-05-02
PL331960A1 (en)	1999-10-11
DK0955314T3 (da)	2004-04-13
AU761652B2 (en)	2003-06-05
DE69913242T2 (de)	2004-09-09
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