ATE255596T1 - Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number: ATE255596T1
Authority: AT; Austria
Prior art keywords: peptide; glucagone; preparation; pharmaceutical compositions; heteroarylcarbonyl
Prior art date: 1998-04-10

Application number

AT99400613T

Other languages

English (en)

Inventor

Bernard Calas

Gerard Grassy

Alain Chavanieu

De Menthiere Cyril Sarrauste

Pierre Renard

Bruno Pfeiffer

Dominique Manechez

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-10

Filing date

1999-03-12

Publication date

2003-12-15

1999-03-12 Application filed by Servier Lab filed Critical Servier Lab

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255596T1 publication Critical patent/ATE255596T1/de

Links

OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 title 1
101710176384 Peptide 1 Proteins 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT99400613T 1998-04-10 1999-03-12 Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen ATE255596T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9804559A FR2777283B1 (fr)	1998-04-10	1998-04-10	Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE255596T1 true ATE255596T1 (de)	2003-12-15

Family

ID=9525150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99400613T ATE255596T1 (de)	1998-04-10	1999-03-12	Peptidanaloge des glucagon-ähnlichen-peptids-1 (7-37), deren herstellung und pharmazeutische zusammensetzungen

Country Status (18)

Country	Link
US (1)	US6620910B1 (de)
EP (1)	EP0955314B1 (de)
JP (1)	JP3787242B2 (de)
CN (1)	CN1305897C (de)
AT (1)	ATE255596T1 (de)
AU (1)	AU761652B2 (de)
BR (1)	BR9902014A (de)
CA (1)	CA2263059A1 (de)
DE (1)	DE69913242T2 (de)
DK (1)	DK0955314T3 (de)
ES (1)	ES2212485T3 (de)
FR (1)	FR2777283B1 (de)
HU (1)	HUP9900604A3 (de)
NO (1)	NO323137B1 (de)
NZ (1)	NZ334379A (de)
PL (1)	PL331960A1 (de)
PT (1)	PT955314E (de)
ZA (1)	ZA992035B (de)

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US7687638B2 (en)	2004-06-04	2010-03-30	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
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ME02005B (me)	2005-09-14	2012-08-31	Takeda Pharmaceuticals Co	Inhibitori dipeptidil peptidaze za lečenje dijabetesa
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KR20080096809A (ko)	2006-02-22	2008-11-03	맨카인드 코포레이션	디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
CN1982336B (zh) *	2006-03-03	2011-01-12	华东师范大学	一种人胰高血糖素样肽-1衍生物及其制备和应用
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TWI428346B (zh)	2006-12-13	2014-03-01	Imp Innovations Ltd	新穎化合物及其等對進食行為影響
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
GB2448895A (en) *	2007-05-01	2008-11-05	Activotec Spp Ltd	GLP-1 like compounds and uses thereof
CN101969927A (zh) *	2007-10-24	2011-02-09	曼金德公司	预防glp-1不良影响的方法
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CN101463081B (zh) *	2009-01-12	2012-07-04	华东师范大学	一种glp-1衍生物
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US8642544B2 (en)	2009-04-01	2014-02-04	Amylin Pharmaceuticals, Llc	N-terminus conformationally constrained GLP-1 receptor agonist compounds
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BR112012033060A2 (pt)	2010-06-21	2018-02-27	Mannkind Corp	métodos de sistema de liberação de fármaco em pó seco
JP2013535471A (ja)	2010-07-28	2013-09-12	アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー	安定化した領域を有するｇｌｐ−１受容体アゴニスト化合物
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1998
- 1998-04-10 FR FR9804559A patent/FR2777283B1/fr not_active Expired - Fee Related
1999
- 1999-02-25 NZ NZ334379A patent/NZ334379A/en unknown
- 1999-03-10 CA CA002263059A patent/CA2263059A1/fr not_active Abandoned
- 1999-03-11 NO NO19991199A patent/NO323137B1/no unknown
- 1999-03-12 PT PT99400613T patent/PT955314E/pt unknown
- 1999-03-12 DE DE69913242T patent/DE69913242T2/de not_active Expired - Fee Related
- 1999-03-12 ZA ZA9902035A patent/ZA992035B/xx unknown
- 1999-03-12 PL PL99331960A patent/PL331960A1/xx not_active IP Right Cessation
- 1999-03-12 HU HU9900604A patent/HUP9900604A3/hu unknown
- 1999-03-12 EP EP99400613A patent/EP0955314B1/de not_active Expired - Lifetime
- 1999-03-12 AT AT99400613T patent/ATE255596T1/de not_active IP Right Cessation
- 1999-03-12 ES ES99400613T patent/ES2212485T3/es not_active Expired - Lifetime
- 1999-03-12 JP JP06691799A patent/JP3787242B2/ja not_active Expired - Fee Related
- 1999-03-12 DK DK99400613T patent/DK0955314T3/da active
- 1999-03-15 US US09/268,578 patent/US6620910B1/en not_active Expired - Fee Related
- 1999-03-15 CN CNB991039874A patent/CN1305897C/zh not_active Expired - Fee Related
- 1999-03-15 BR BR9902014-9A patent/BR9902014A/pt not_active Application Discontinuation
- 1999-04-09 AU AU23688/99A patent/AU761652B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0955314B1 (de)	2003-12-03
HUP9900604A2 (hu)	1999-09-28
NO991199L (no)	1999-10-11
US6620910B1 (en)	2003-09-16
FR2777283B1 (fr)	2000-11-24
CN1232038A (zh)	1999-10-20
ES2212485T3 (es)	2004-07-16
NO991199D0 (no)	1999-03-11
AU761652B2 (en)	2003-06-05
BR9902014A (pt)	2000-05-02
PL331960A1 (en)	1999-10-11
CA2263059A1 (fr)	1999-10-10
DE69913242D1 (de)	2004-01-15
AU2368899A (en)	1999-10-21
FR2777283A1 (fr)	1999-10-15
JPH11310597A (ja)	1999-11-09
DK0955314T3 (da)	2004-04-13
PT955314E (pt)	2004-03-31
ZA992035B (en)	1999-09-27
DE69913242T2 (de)	2004-09-09
HUP9900604A3 (en)	2001-01-29
EP0955314A2 (de)	1999-11-10
JP3787242B2 (ja)	2006-06-21
NZ334379A (en)	1999-10-28
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