BR9903302A - Processo para preparação de um complexo de carvão-gm1, e, método analìtico para determinar o gm1 não derivado em soluções aquosas empregando a técnica de cromatografia lìquida de alta eficiência - Google Patents

Processo para preparação de um complexo de carvão-gm1, e, método analìtico para determinar o gm1 não derivado em soluções aquosas empregando a técnica de cromatografia lìquida de alta eficiência

Info

Publication number
BR9903302A
BR9903302A BR9903302-0A BR9903302A BR9903302A BR 9903302 A BR9903302 A BR 9903302A BR 9903302 A BR9903302 A BR 9903302A BR 9903302 A BR9903302 A BR 9903302A
Authority
BR
Brazil
Prior art keywords
liquid chromatography
complex
analytical method
preparation
chromatography technique
Prior art date
Application number
BR9903302-0A
Other languages
English (en)
Inventor
Pedro Goncalves De Oliveira
Silvia Storpirtis
Original Assignee
Trb Pharma Ind Quimica E Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trb Pharma Ind Quimica E Farma filed Critical Trb Pharma Ind Quimica E Farma
Publication of BR9903302A publication Critical patent/BR9903302A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ceramic Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE UM COMPLEXO DE CARVãO-GMI, E, MéTODO ANALìTICO PARA DETERMINAR O GM1 NãO DERIVADO EM SOLUçõES AQUOSAS EMPREGANDO A TéCNICA DE CROMATOGRAFIA LìQUIDA DE ALTA EFICIêNCIA" A invenção fornece processo para preparar complexo de adsorção carvão-GM1 estável em diferentes valores de pH. Tal processo baseia-se no método de suspensão, sendo apresentado exemplo de formulação. é também objeto da presente invenção um método analítico para determinar o GM1 não derivado em soluções aquosas empregando a técnica de cromatografia líquida de alta eficiência.
BR9903302-0A 1999-07-30 1999-07-30 Processo para preparação de um complexo de carvão-gm1, e, método analìtico para determinar o gm1 não derivado em soluções aquosas empregando a técnica de cromatografia lìquida de alta eficiência BR9903302A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI9903302-0 BRPI9903302B8 (pt) 1999-07-30 1999-07-30 processo para preparaÇço de um complexo de carvço-gm1, e, mÉtodo analÍtico para determinar gm1 nço derivado.

Publications (1)

Publication Number Publication Date
BR9903302A true BR9903302A (pt) 2001-03-06

Family

ID=77351465

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9903302-0A BR9903302A (pt) 1999-07-30 1999-07-30 Processo para preparação de um complexo de carvão-gm1, e, método analìtico para determinar o gm1 não derivado em soluções aquosas empregando a técnica de cromatografia lìquida de alta eficiência
BRPI9903302-0 BRPI9903302B8 (pt) 1999-07-30 1999-07-30 processo para preparaÇço de um complexo de carvço-gm1, e, mÉtodo analÍtico para determinar gm1 nço derivado.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI9903302-0 BRPI9903302B8 (pt) 1999-07-30 1999-07-30 processo para preparaÇço de um complexo de carvço-gm1, e, mÉtodo analÍtico para determinar gm1 nço derivado.

Country Status (10)

Country Link
US (1) US6602991B1 (pt)
EP (1) EP1203002B1 (pt)
CN (1) CN1153777C (pt)
AT (1) ATE241636T1 (pt)
AU (1) AU6142300A (pt)
BR (2) BR9903302A (pt)
CA (1) CA2380481C (pt)
DE (1) DE60003042D1 (pt)
HK (1) HK1049013B (pt)
WO (1) WO2001009151A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7877929B2 (en) 2007-08-04 2011-02-01 Rezzorb, Llc Method and apparatus for reducing fertilizer use in agricultural operations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016702B1 (fr) * 1979-03-16 1985-02-20 Institut Merieux Médicament, notamment pour le traitement du choléra, et compositions pharmaceutiques le contenant
JPS6112696A (ja) * 1984-06-29 1986-01-21 Mitsui Toatsu Chem Inc ガングリオシドの濃縮方法

Also Published As

Publication number Publication date
ATE241636T1 (de) 2003-06-15
AU6142300A (en) 2001-02-19
WO2001009151A1 (en) 2001-02-08
BRPI9903302B8 (pt) 2021-07-06
BRPI9903302A (pt) 2001-03-06
CA2380481A1 (en) 2001-02-08
US6602991B1 (en) 2003-08-05
CN1365365A (zh) 2002-08-21
HK1049013A1 (zh) 2003-04-25
BRPI9903302B1 (pt) 2011-07-26
EP1203002B1 (en) 2003-05-28
EP1203002A1 (en) 2002-05-08
DE60003042D1 (de) 2003-07-03
CA2380481C (en) 2009-07-21
CN1153777C (zh) 2004-06-16
HK1049013B (zh) 2005-03-24

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