BR9907882A - Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite - Google Patents

Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite

Info

Publication number
BR9907882A
BR9907882A BR9907882-1A BR9907882A BR9907882A BR 9907882 A BR9907882 A BR 9907882A BR 9907882 A BR9907882 A BR 9907882A BR 9907882 A BR9907882 A BR 9907882A
Authority
BR
Brazil
Prior art keywords
dideoxy
imino
hepatitis virus
virus infections
unsubstituted
Prior art date
Application number
BR9907882-1A
Other languages
English (en)
Inventor
Richard A Mueller
Martin L Bryant
Richard A Partis
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/023,401 external-priority patent/US20030100532A1/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9907882A publication Critical patent/BR9907882A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"USO DE COMPOSTOS DE 1,5-DIDESóXI-1,5-IMINO-D-GLUCITOL N-SUBSTITUìDOS PARA O TRATAMENTO DE INFECçõES DE VìRUS DE HEPATITE"<D>. Providos são métodos e composições para o tratamento de infecções de vírus de hepatite em mamíferos, especialmente seres humanos. Os métodos compreende (1) administração de compostos 1,5-didesóxi-,1,5-imino-D-glucitol N-substituídos sozinhos ou em combinação com agentes antivirais de nucleosídeo, agentes antivirais de nucleotídeo, suas misturas, ou agentes de imunomodulação/imunoestimulação, ou (2) administracão de compostos 1,5-didesóxi-,1,5-imino-D-glucitol N-substituídos sozinhos ou em combinação com agentes antivirais de nucleosídeo, agentes antivirais de nucleotídeo ou suas misturas e agentes de imunomodulação/imunoestimulante.
BR9907882-1A 1998-02-12 1999-02-12 Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite BR9907882A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7450898P 1998-02-12 1998-02-12
US09/023,401 US20030100532A1 (en) 1997-02-14 1998-02-12 Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
PCT/US1999/001874 WO1999040916A1 (en) 1998-02-12 1999-02-12 Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections

Publications (1)

Publication Number Publication Date
BR9907882A true BR9907882A (pt) 2000-10-17

Family

ID=26697090

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907882-1A BR9907882A (pt) 1998-02-12 1999-02-12 Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite

Country Status (16)

Country Link
US (2) US6809083B1 (pt)
EP (1) EP1061922B9 (pt)
JP (1) JP2002502875A (pt)
KR (1) KR20010040937A (pt)
AT (1) ATE331515T1 (pt)
AU (2) AU762125B2 (pt)
BR (1) BR9907882A (pt)
CA (1) CA2319713C (pt)
DE (1) DE69932154T2 (pt)
EA (1) EA004705B1 (pt)
ES (1) ES2272054T3 (pt)
ID (1) ID27290A (pt)
MY (1) MY122185A (pt)
TR (1) TR200002323T2 (pt)
TW (1) TWI222867B (pt)
WO (1) WO1999040916A1 (pt)

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US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
US6809083B1 (en) 1998-02-12 2004-10-26 Richard A. Mueller Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ATE402701T1 (de) 1999-02-12 2008-08-15 United Therapeutics Corp N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen
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ES2302697T3 (es) 1999-08-10 2008-08-01 The Chancellor, Masters And Scholars Of The University Of Oxford Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
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JP5600329B2 (ja) 2009-02-23 2014-10-01 ユナイテッド セラピューティクス コーポレーション イミノ糖およびウイルス性疾患を治療する方法
CN102427804A (zh) * 2009-03-27 2012-04-25 牛津大学之校长及学者 降低胆固醇水平的脂质体
JP5634510B2 (ja) 2009-06-12 2014-12-03 ユナイテッド セラピューティクス コーポレイション イミノ糖ならびにブニヤウイルスおよびトガウイルス疾患を治療する方法
KR101459530B1 (ko) * 2009-09-04 2014-11-07 유나이티드 세러퓨틱스 코오포레이션 폭스바이러스 감염의 치료 방법
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Also Published As

Publication number Publication date
MY122185A (en) 2006-03-31
EP1061922B9 (en) 2007-03-07
CA2319713C (en) 2012-06-26
TWI222867B (en) 2004-11-01
ES2272054T3 (es) 2007-04-16
ID27290A (id) 2001-03-22
ATE331515T1 (de) 2006-07-15
EP1061922B1 (en) 2006-06-28
AU762125B2 (en) 2003-06-19
AU2759599A (en) 1999-08-30
EA200000836A1 (ru) 2001-04-23
US20050267153A1 (en) 2005-12-01
WO1999040916A1 (en) 1999-08-19
EP1061922A1 (en) 2000-12-27
JP2002502875A (ja) 2002-01-29
EA004705B1 (ru) 2004-06-24
AU2003248024A1 (en) 2003-10-30
DE69932154T2 (de) 2007-05-31
DE69932154D1 (de) 2006-08-10
KR20010040937A (ko) 2001-05-15
TR200002323T2 (tr) 2000-12-21
US6809083B1 (en) 2004-10-26
CA2319713A1 (en) 1999-08-19

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

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