ES2087277T3 - Procedimiento para producir 1-desoxinojirimicina n-sustituida. - Google Patents

Procedimiento para producir 1-desoxinojirimicina n-sustituida.

Info

Publication number
ES2087277T3
ES2087277T3 ES91870145T ES91870145T ES2087277T3 ES 2087277 T3 ES2087277 T3 ES 2087277T3 ES 91870145 T ES91870145 T ES 91870145T ES 91870145 T ES91870145 T ES 91870145T ES 2087277 T3 ES2087277 T3 ES 2087277T3
Authority
ES
Spain
Prior art keywords
substituted
procedure
produce
deoxynojirimycin
oxidizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91870145T
Other languages
English (en)
Inventor
Roy Walter Grabner
Bryan Hayden Landis
Ping Tu Wang
Michael Lee Prunier
Mike Gust Scaros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Monsanto Co
Original Assignee
GD Searle LLC
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC, Monsanto Co filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2087277T3 publication Critical patent/ES2087277T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA INVENCION ES UN PROCESO PARA LA PRODUCCION DE GLUCAMINAS SUSTITUIDAS-N , UN PROCESO PARA OXIDAR UNA GLUCAMINA SUSTITUIDA-N CON UN MICROBIO OXIDANTE O UN EXTRACTO DEL MISMO, Y UN PROCESO PARA OXIDAR UNA GLUCAMINA SUSTITUIDA-N CON UN MICROBIO OXIDANTE O UN EXTRACTO DEL MISMO Y REDUCIR LA GLUCAMINA SUSTITUIDA-N OXIDADA A N-SUSTITUIDA-1-DEOXINOJIRIMICINA. ADEMAS, SE EXPONE EL PROCESO DE UNA SOLA MARMITA PARA LA PRODUCCION DE N-SUSTITUIDA-1-DEOXINOJIRIMICINA DE LA GLUCOSA-D.
ES91870145T 1990-09-20 1991-09-19 Procedimiento para producir 1-desoxinojirimicina n-sustituida. Expired - Lifetime ES2087277T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58558890A 1990-09-20 1990-09-20

Publications (1)

Publication Number Publication Date
ES2087277T3 true ES2087277T3 (es) 1996-07-16

Family

ID=24342101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91870145T Expired - Lifetime ES2087277T3 (es) 1990-09-20 1991-09-19 Procedimiento para producir 1-desoxinojirimicina n-sustituida.

Country Status (9)

Country Link
US (4) US5610039A (es)
EP (1) EP0477160B1 (es)
JP (2) JP3162123B2 (es)
AT (1) ATE137266T1 (es)
CA (1) CA2051855C (es)
DE (1) DE69119010T2 (es)
DK (1) DK0477160T3 (es)
ES (1) ES2087277T3 (es)
GR (1) GR3020532T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401645A (en) * 1992-03-16 1995-03-28 Monsanto Company Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium
US6177447B1 (en) * 1996-07-15 2001-01-23 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
JP2001522833A (ja) 1997-11-10 2001-11-20 ジー・ディー・サール・アンド・カンパニー 多剤耐性を治療するためのアルキル化イミノ糖類の使用
EA004705B1 (ru) 1998-02-12 2004-06-24 Дж.Д.Серл Энд Ко. Применение n-замещенных 1,5-дидезокси-1,5-имино-d-глюцитных производных для лечения инфекций, вызываемых вирусами гепатита
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
ES2311921T3 (es) 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
KR100446483B1 (ko) 2000-03-31 2004-09-01 미시간 스테이트 유니버시티 옥심 또는 이민으로부터 1,5-디데옥시-1,5-이미노 헥시톨제조방법
AU2001283182A1 (en) * 2000-08-09 2002-02-18 Skybitz, Inc. Frequency translator using a cordic phase rotator
CN1300098C (zh) * 2003-10-28 2007-02-14 浙江医药股份有限公司新昌制药厂 N－丁基－葡糖胺的合成方法
JP3916166B2 (ja) * 2004-09-27 2007-05-16 学校法人慶應義塾 化合物ライブラリーの作製方法、並びに、スクリーニング方法
CN1328270C (zh) * 2005-09-26 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产米格列醇的方法
CA2666814A1 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
EP1903034A1 (en) * 2006-09-19 2008-03-26 Technische Universität Graz Iminosugar glycoconjugates
CN101289418B (zh) * 2007-04-19 2011-02-02 浙江医药股份有限公司新昌制药厂 米格列醇晶体及其制备方法
CN101302549B (zh) * 2007-05-09 2013-06-05 浙江医药股份有限公司新昌制药厂 高纯度米格列醇的生产方法
US8225824B2 (en) * 2007-11-16 2012-07-24 Intelligent Hospital Systems, Ltd. Method and apparatus for automated fluid transfer operations
CN101195602B (zh) * 2007-12-25 2011-03-23 郑州大学 1-脱氧野尻毒素衍生物、其制备方法及其应用
KR101698436B1 (ko) * 2010-08-11 2017-01-20 (주)아모레퍼시픽 데아닌 유도체, 이의 제조방법 및 이를 함유하는 항여드름용 피부 외용제 조성물
CN105968042B (zh) * 2016-07-15 2019-06-07 四川维奥制药有限公司 一种米格列醇的制备方法
CN107935865A (zh) * 2017-10-31 2018-04-20 浙江工业大学 米格列醇中间体1‑脱氧‑1‑(2‑羟乙基氨基)‑d‑葡萄糖醇的制备方法
CN107746385A (zh) * 2017-10-31 2018-03-02 浙江工业大学 一种米格列醇的制备方法
JP2021514200A (ja) * 2018-01-26 2021-06-10 浙江工▲業▼大学 グルコノバクターオキシダンスのソルビトールデヒドロゲナーゼおよびコエンザイムピロロキノリンキニーネの合成を促進する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
JPS5317677B2 (es) * 1973-09-25 1978-06-09
US3919316A (en) * 1974-08-05 1975-11-11 Lilly Co Eli 2-Aminodichlorotetralins
DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE2907190A1 (de) * 1979-02-23 1980-08-28 Bayer Ag 1-desoxynojirimycin-herstellung
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3049446A1 (de) * 1980-12-30 1982-07-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten
DE3611841A1 (de) * 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
DE3814549A1 (de) * 1987-10-30 1989-05-18 Bayer Ag N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof

Also Published As

Publication number Publication date
JP2001058975A (ja) 2001-03-06
CA2051855C (en) 2002-11-26
CA2051855A1 (en) 1992-03-21
US20010019837A1 (en) 2001-09-06
JPH04342567A (ja) 1992-11-30
GR3020532T3 (en) 1996-10-31
US5610039A (en) 1997-03-11
DE69119010T2 (de) 1996-11-28
DK0477160T3 (da) 1996-05-20
DE69119010D1 (de) 1996-05-30
ATE137266T1 (de) 1996-05-15
US6552176B2 (en) 2003-04-22
JP3162123B2 (ja) 2001-04-25
US5916784A (en) 1999-06-29
EP0477160B1 (en) 1996-04-24
US5602013A (en) 1997-02-11
EP0477160A1 (en) 1992-03-25

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