BR9911367A - Processo para preparação de derivados de pirimidinona - Google Patents

Processo para preparação de derivados de pirimidinona

Info

Publication number
BR9911367A
BR9911367A BR9911367-8A BR9911367A BR9911367A BR 9911367 A BR9911367 A BR 9911367A BR 9911367 A BR9911367 A BR 9911367A BR 9911367 A BR9911367 A BR 9911367A
Authority
BR
Brazil
Prior art keywords
formula
cycloalkyl
compound
pyrimidinone derivatives
alkynyl
Prior art date
Application number
BR9911367-8A
Other languages
English (en)
Inventor
Harald Walter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9813238.4A external-priority patent/GB9813238D0/en
Priority claimed from GBGB9814088.2A external-priority patent/GB9814088D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9911367A publication Critical patent/BR9911367A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/68—Compounds containing any of the groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA PREPARAçãO DE DERIVADOS DE PIRIMIDINONA"<D>. Processo para a preparação de compostos tendo proteção de planta, em particular propriedades fungicidas, da fórmula I em que A é um anel heterocíclico de 5 membros fundido, o qual pode ser saturado ou insaturado, aromático ou não-aromático e o qual pode conter um ou dois hetero átomos O, S e/ou N, ou é benzo, pirido ou piridazino fundido; R~ 1~ e R~ 2~ são grupos as quais são inertes às reações; R~ 3~ é optativamente alquila C~ 1~-C~ 8~, alquenila C~ 2~-C~ 8~, alquinila C~ 2~-C~ 8~, cicloalquila C~ 3~-C~ 6~ ou cicloalquil C~ 3~-C~ 6~-alquila C~ 1~-C~ 6~ substituídos; e R~ 4~ é optativamente alquila C~ 1~-C~ 6~, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, cicloalquila C~ 3~-C~ 6~ ou cicloalquil C~ 3~-C~ 6~-alquila C~ 1~-C~ 6~ substituídos; em qual processo (a) um composto de fórmula II, em que A, R~ 1~, R~ 2~ e R~ 3~ são como definido por fórmula I, é reagido com um ortocarbonato da fórmula III, em que R~ 4~ é como definido por fórmula I e Y é OR~ 4~, CN ou NO~ 2~, para dar o composto intermediário de fórmula IV; e subseq³entemente (b) o composto da fórmula IV é ciclizado a um composto da fórmula I.
BR9911367-8A 1998-06-19 1999-06-17 Processo para preparação de derivados de pirimidinona BR9911367A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9813238.4A GB9813238D0 (en) 1998-06-19 1998-06-19 Organic compounds
GBGB9814088.2A GB9814088D0 (en) 1998-06-30 1998-06-30 Organic compounds
PCT/EP1999/004188 WO1999067202A1 (en) 1998-06-19 1999-06-17 Process for preparation of pyrimidinone derivatives

Publications (1)

Publication Number Publication Date
BR9911367A true BR9911367A (pt) 2001-03-13

Family

ID=26313903

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911367-8A BR9911367A (pt) 1998-06-19 1999-06-17 Processo para preparação de derivados de pirimidinona

Country Status (6)

Country Link
US (1) US20010018405A1 (pt)
EP (1) EP1087939A1 (pt)
JP (1) JP2002518471A (pt)
AU (1) AU4514799A (pt)
BR (1) BR9911367A (pt)
WO (1) WO1999067202A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104945332B (zh) * 2014-03-31 2017-10-17 中国科学院广州生物医药与健康研究院 埃罗替尼的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026722A1 (en) * 1993-05-12 1994-11-24 E.I. Du Pont De Nemours And Company Fungicidal fused bicyclic pyrimidinones
JP4010563B2 (ja) * 1995-07-05 2007-11-21 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 殺菌・殺カビ性のピリミジノン類
PT888359E (pt) * 1996-03-11 2002-10-31 Syngenta Participations Ag Derivados de pirimidin-4-ona como pesticida
TW434228B (en) * 1996-06-18 2001-05-16 Du Pont Preparation of fungicidal quinazolinones and useful intermediates
DE19642451A1 (de) * 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide

Also Published As

Publication number Publication date
JP2002518471A (ja) 2002-06-25
WO1999067202A1 (en) 1999-12-29
AU4514799A (en) 2000-01-10
EP1087939A1 (en) 2001-04-04
US20010018405A1 (en) 2001-08-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5,6,7 E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.