BR0308145A - Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto - Google Patents

Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto

Info

Publication number
BR0308145A
BR0308145A BR0308145-1A BR0308145A BR0308145A BR 0308145 A BR0308145 A BR 0308145A BR 0308145 A BR0308145 A BR 0308145A BR 0308145 A BR0308145 A BR 0308145A
Authority
BR
Brazil
Prior art keywords
compound
hydroxy
halo
alkyl
hydrogen
Prior art date
Application number
BR0308145-1A
Other languages
English (en)
Inventor
Paul Robert Owen Whittamore
Stuart Norman Lile Bennett
Iain Simpson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0308145A publication Critical patent/BR0308145A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Amidas heterocíclicas da fórmula (1): em que: Z é CH ou nitrogênio; R^ 4^ e R^ 5^ juntos são ou -S-C(R^ 6^)=C(R^ 7^)- ou -C(R^ 7^)=C(R^ 6^)-S-; R^ 6^ e R^ 7^ são selecionados a partir, por exemplo, de hidrogênio, halo, alquila C~ 1-4~ e alcanoíla C~ 1-4~; A é fenileno ou heteroarileno; n é 0, 1 ou 2; R^ 1^ é selecionado, por exemplo, a partir de halo, nitro, ciano, hidróxi, carbóxi; r é 1 ou 2; Y é -NR^ 2^R^ 3^ ou - OR^ 3^; R^ 2^ e R^ 3^ são selecionados a partir de, por exemplo, hidrogênio, hidróxi, arila, heterociclila e alquila C~ 1-4~ (opcionalmente substituído por 1 ou 2 grupos R^ 8^); R^ 4^ é selecionado, por exemplo, a partir de hidrogênio, halo, nitro, ciano, hidróxi, alquila C~ 1-4~ e alcanoíla; R^ 8^ é selecionado, por exemplo, a partir de hidróxi, -COCOOR^ 9^,- C(O)N(R^ 9^)(R^ 10^), - NHC(O)R^ 9^, (R^ 9^) (R^ 10^)N- e -COOR^ 9^; R^ 9^ e R^ 10^ são selecionados, por exemplo, a partir de hidrogênio, hidróxi, alquila C~ 1-4~ (opcionalmente substituido por 1 ou 2 R^ 13^); R^ 13^ é selecionado a partir de hidróxi, halo, trifluorometila e alcóxi C~ 1-4~; ou um sal farmaceuticamente aceitável ou pró-droga dos mesmos; possuem atividade inibitória de glicogênio fosforilase e portanto possuem valor no tratamento de estados de doença associados com atividade de glicogênio fosforilase aumentada. Processos para a manufatura dos referidos derivados de amida heterocíclica e composições farmacêuticas contendo os mesmos são descritos.
BR0308145-1A 2002-03-06 2003-03-04 Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto BR0308145A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0205170.4A GB0205170D0 (en) 2002-03-06 2002-03-06 Chemical compounds
PCT/GB2003/000875 WO2003074531A1 (en) 2002-03-06 2003-03-04 Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity

Publications (1)

Publication Number Publication Date
BR0308145A true BR0308145A (pt) 2004-12-07

Family

ID=9932334

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308145-1A BR0308145A (pt) 2002-03-06 2003-03-04 Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto

Country Status (25)

Country Link
US (1) US7122567B2 (pt)
EP (1) EP1483271B1 (pt)
JP (1) JP2005524669A (pt)
KR (1) KR20040091101A (pt)
CN (1) CN1307183C (pt)
AR (1) AR038886A1 (pt)
AT (1) ATE346072T1 (pt)
AU (1) AU2003209445A1 (pt)
BR (1) BR0308145A (pt)
CA (1) CA2477125A1 (pt)
DE (1) DE60309849T2 (pt)
DK (1) DK1483271T3 (pt)
ES (1) ES2276092T3 (pt)
GB (1) GB0205170D0 (pt)
IL (1) IL163802A0 (pt)
IS (1) IS7433A (pt)
MX (1) MXPA04008611A (pt)
NO (1) NO20044033L (pt)
NZ (1) NZ534684A (pt)
PL (1) PL372772A1 (pt)
PT (1) PT1483271E (pt)
RU (1) RU2004125145A (pt)
TW (1) TW200306176A (pt)
WO (1) WO2003074531A1 (pt)
ZA (1) ZA200406685B (pt)

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Also Published As

Publication number Publication date
EP1483271A1 (en) 2004-12-08
NO20044033L (no) 2004-11-25
RU2004125145A (ru) 2005-06-10
KR20040091101A (ko) 2004-10-27
PL372772A1 (en) 2005-08-08
CN1307183C (zh) 2007-03-28
WO2003074531A1 (en) 2003-09-12
DE60309849D1 (de) 2007-01-04
DE60309849T2 (de) 2007-06-14
JP2005524669A (ja) 2005-08-18
ATE346072T1 (de) 2006-12-15
TW200306176A (en) 2003-11-16
CA2477125A1 (en) 2003-09-12
IS7433A (is) 2004-09-01
ZA200406685B (en) 2005-10-31
US20050131052A1 (en) 2005-06-16
PT1483271E (pt) 2007-02-28
AU2003209445A1 (en) 2003-09-16
NZ534684A (en) 2006-02-24
MXPA04008611A (es) 2004-12-06
HK1070365A1 (en) 2005-06-17
EP1483271B1 (en) 2006-11-22
GB0205170D0 (en) 2002-04-17
US7122567B2 (en) 2006-10-17
IL163802A0 (en) 2005-12-18
AR038886A1 (es) 2005-02-02
CN1639167A (zh) 2005-07-13
DK1483271T3 (da) 2007-02-19
ES2276092T3 (es) 2007-06-16

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