BR9913052A - Rapamicinas fotocilizadas - Google Patents
Rapamicinas fotocilizadasInfo
- Publication number
- BR9913052A BR9913052A BR9913052-1A BR9913052A BR9913052A BR 9913052 A BR9913052 A BR 9913052A BR 9913052 A BR9913052 A BR 9913052A BR 9913052 A BR9913052 A BR 9913052A
- Authority
- BR
- Brazil
- Prior art keywords
- photocilized
- rapamycin
- antiproliferative
- antiinflammatory
- immunosuppressive
- Prior art date
Links
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção:<B>"RAPAMICINAS FOTOCICLIZADAS"<D>. A presente invenção refere-se a um composto de estrutura (I) ou (II) ou um éter na posição 31- ou 42- dos mesmos, que é de utilidade como um agente imunossupressor, antiinflamatório, antifungicida e antitumor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13542198A | 1998-08-17 | 1998-08-17 | |
| PCT/US1999/018564 WO2000009510A1 (en) | 1998-08-17 | 1999-08-16 | Photocyclized rapamycins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9913052A true BR9913052A (pt) | 2001-05-08 |
Family
ID=22468034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9913052-1A BR9913052A (pt) | 1998-08-17 | 1999-08-16 | Rapamicinas fotocilizadas |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1105395B1 (pt) |
| JP (1) | JP2002522543A (pt) |
| CN (1) | CN1323310A (pt) |
| AT (1) | ATE219492T1 (pt) |
| AU (1) | AU5487499A (pt) |
| BR (1) | BR9913052A (pt) |
| CA (1) | CA2340700A1 (pt) |
| DE (1) | DE69901907T2 (pt) |
| DK (1) | DK1105395T3 (pt) |
| ES (1) | ES2179671T3 (pt) |
| PT (1) | PT1105395E (pt) |
| WO (1) | WO2000009510A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| CA2590254A1 (en) | 2004-12-20 | 2006-06-29 | Wyeth | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
| AU2005319454B2 (en) | 2004-12-20 | 2012-08-09 | Wyeth | Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
-
1999
- 1999-08-16 BR BR9913052-1A patent/BR9913052A/pt not_active IP Right Cessation
- 1999-08-16 AU AU54874/99A patent/AU5487499A/en not_active Abandoned
- 1999-08-16 JP JP2000564961A patent/JP2002522543A/ja active Pending
- 1999-08-16 CN CN99812174A patent/CN1323310A/zh active Pending
- 1999-08-16 WO PCT/US1999/018564 patent/WO2000009510A1/en not_active Ceased
- 1999-08-16 DK DK99941166T patent/DK1105395T3/da active
- 1999-08-16 DE DE69901907T patent/DE69901907T2/de not_active Expired - Fee Related
- 1999-08-16 AT AT99941166T patent/ATE219492T1/de not_active IP Right Cessation
- 1999-08-16 ES ES99941166T patent/ES2179671T3/es not_active Expired - Lifetime
- 1999-08-16 EP EP99941166A patent/EP1105395B1/en not_active Expired - Lifetime
- 1999-08-16 CA CA002340700A patent/CA2340700A1/en not_active Abandoned
- 1999-08-16 PT PT99941166T patent/PT1105395E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1105395T3 (da) | 2002-10-14 |
| ATE219492T1 (de) | 2002-07-15 |
| CN1323310A (zh) | 2001-11-21 |
| PT1105395E (pt) | 2002-09-30 |
| CA2340700A1 (en) | 2000-02-24 |
| EP1105395B1 (en) | 2002-06-19 |
| DE69901907T2 (de) | 2002-12-19 |
| EP1105395A1 (en) | 2001-06-13 |
| AU5487499A (en) | 2000-03-06 |
| JP2002522543A (ja) | 2002-07-23 |
| ES2179671T3 (es) | 2003-01-16 |
| DE69901907D1 (de) | 2002-07-25 |
| WO2000009510A1 (en) | 2000-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |