BRPI0011369B8 - método de detecção precoce e kit de diagnóstico precoce de uma infecção flaviviral, processo de purificação da proteína ns1 de um flavivírus,composição imunogênca,utilização da proteína ns1,de pelo menos um anticorpo monoclonal anti-ns1 e da proteína ns1 de forma hexamérica,e, processo de expressão de um polinucleotídeo codificado para a proteína ns1 de um vírus da dengue - Google Patents

método de detecção precoce e kit de diagnóstico precoce de uma infecção flaviviral, processo de purificação da proteína ns1 de um flavivírus,composição imunogênca,utilização da proteína ns1,de pelo menos um anticorpo monoclonal anti-ns1 e da proteína ns1 de forma hexamérica,e, processo de expressão de um polinucleotídeo codificado para a proteína ns1 de um vírus da dengue Download PDF

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Publication number
BRPI0011369B8
BRPI0011369B8 BRPI0011369A BR0011369A BRPI0011369B8 BR PI0011369 B8 BRPI0011369 B8 BR PI0011369B8 BR PI0011369 A BRPI0011369 A BR PI0011369A BR 0011369 A BR0011369 A BR 0011369A BR PI0011369 B8 BRPI0011369 B8 BR PI0011369B8
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BR
Brazil
Prior art keywords
protein
flavivirus
early
purification
immunogenic composition
Prior art date
Application number
BRPI0011369A
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English (en)
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BRPI0011369B1 (pt
BR0011369A (pt
Inventor
Talarmin Antoine
Megret Françoise
Flamand Marie
Despres Philippe
Alcon Sophie
Deubel Vicente
Original Assignee
Pasteur Institut
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Filing date
Publication date
Priority claimed from FR9907290A external-priority patent/FR2794864A1/fr
Application filed by Pasteur Institut filed Critical Pasteur Institut
Publication of BR0011369A publication Critical patent/BR0011369A/pt
Publication of BRPI0011369B1 publication Critical patent/BRPI0011369B1/pt
Publication of BRPI0011369B8 publication Critical patent/BRPI0011369B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"método de detecção precoce de uma infecção flaviviral, kit de diagnóstico precoce, processo de purificação da proteína ns1 de um flavivírus, composição imunogene, utilização da proteína ns1, de pelo menos um anticorpo monoclonal anti-ns1, e, processo de expressão de um polinucleotídeo codificando para a proteína ns1 de um vírus da dengue". método de detecção precoce de uma infecção flaviviral compreendendo a detecção da glicoproteína não estrutural ns1 de um flavivírus em uma amostra biológica, durante a fase clínica da infecção, por um método imunológico empregando pelo menos dois anticorpos idênticos ou diferentes, o primeiro anticorpo sendo constituído por anticorpos policlonais ou monoclonais previamente selecionados para sua afinidade elevada para a referida proteína ns1 de forma hexamérica.
BRPI0011369A 1999-06-09 2000-06-09 método de detecção precoce e kit de diagnóstico precoce de uma infecção flaviviral, processo de purificação da proteína ns1 de um flavivírus,composição imunogênca,utilização da proteína ns1,de pelo menos um anticorpo monoclonal anti-ns1 e da proteína ns1 de forma hexamérica,e, processo de expressão de um polinucleotídeo codificado para a proteína ns1 de um vírus da dengue BRPI0011369B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9907290A FR2794864A1 (fr) 1999-06-09 1999-06-09 Methode de detection precoce des flavivirus et ses applications
FR99/07290 1999-06-09
FR9907361A FR2794865B1 (fr) 1999-06-09 1999-06-10 Methode de detection precoce des flavivirus et ses applications
FR99/07361 1999-06-10
PCT/FR2000/001620 WO2000075665A1 (fr) 1999-06-09 2000-06-09 Detection precoce des flavivirus en utilisant la clycoproteine ns1

Publications (3)

Publication Number Publication Date
BR0011369A BR0011369A (pt) 2003-08-12
BRPI0011369B1 BRPI0011369B1 (pt) 2019-03-19
BRPI0011369B8 true BRPI0011369B8 (pt) 2021-05-25

Family

ID=26234982

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0011369A BRPI0011369B8 (pt) 1999-06-09 2000-06-09 método de detecção precoce e kit de diagnóstico precoce de uma infecção flaviviral, processo de purificação da proteína ns1 de um flavivírus,composição imunogênca,utilização da proteína ns1,de pelo menos um anticorpo monoclonal anti-ns1 e da proteína ns1 de forma hexamérica,e, processo de expressão de um polinucleotídeo codificado para a proteína ns1 de um vírus da dengue

Country Status (15)

Country Link
US (5) US6870032B1 (pt)
EP (1) EP1190257B1 (pt)
JP (1) JP4625215B2 (pt)
KR (1) KR20020042533A (pt)
CN (1) CN1360678B (pt)
AT (1) ATE274701T1 (pt)
AU (1) AU776844B2 (pt)
BR (1) BRPI0011369B8 (pt)
DE (1) DE60013287T2 (pt)
ES (1) ES2226894T3 (pt)
FR (1) FR2794865B1 (pt)
HK (1) HK1045729B (pt)
MX (1) MXPA01012662A (pt)
PT (1) PT1190257E (pt)
WO (1) WO2000075665A1 (pt)

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FR2794865B1 (fr) * 1999-06-09 2003-04-18 Pasteur Institut Methode de detection precoce des flavivirus et ses applications
CA2467397A1 (en) * 2001-11-26 2003-06-05 Replikun Biotech Pty Ltd Flavivirus vaccine delivery system
US7473424B2 (en) * 2003-01-31 2009-01-06 The Scripps Research Institute Anti-dengue virus antibodies and compositions
US7189403B2 (en) * 2003-06-30 2007-03-13 Institut Pasteur Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
WO2005024427A2 (en) 2003-09-09 2005-03-17 Idexx Laboratories, Inc. Detection of west nile virus infection and vaccination
US7074555B2 (en) * 2004-04-28 2006-07-11 Idexx Laboratories, Inc. Detection of West Nile Virus
FR2870126B1 (fr) * 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
WO2006088478A2 (en) * 2004-06-18 2006-08-24 Novartis Vaccines And Diagnostics Inc. Methods and reagents for diagnosing hantavirus infection
FR2871888A1 (fr) * 2004-06-22 2005-12-23 Pasteur Institut Methode de diagnostic ou de depistage d'une infection clinique ou asymptomatique par un flavivirus du groupe encephalitique
US8222029B2 (en) 2005-05-16 2012-07-17 Institut Pasteur Lentiviral vector-based vaccine
US20070211241A1 (en) * 2006-02-24 2007-09-13 Noriyuki Aizawa Optical defect inspection apparatus
US7629117B2 (en) * 2006-06-20 2009-12-08 Mahidol University Determination of risk of developing dengue hemorrhagic fever/dengue shock syndrome, methods and compositions therefor
US20100068147A1 (en) * 2006-10-05 2010-03-18 Agency for Science , Technology and Research Dengue diagnosis and treatment
CN101226196B (zh) * 2008-02-02 2012-05-09 南方医科大学 一种检测ⅱ型登革病毒ns1抗原的免疫诊断试剂盒
US20090275499A1 (en) * 2008-02-29 2009-11-05 Marie Flamand Nonstructural protein ns1 as a novel therapeutic target against flaviviruses
CN101551393B (zh) * 2009-04-02 2012-09-19 南方医科大学 一种检测ⅳ型登革病毒ns1抗原的免疫诊断试剂盒
US8920804B2 (en) 2011-12-22 2014-12-30 Inbios International, Inc. Methods and materials for the detection of dengue virus infection
US10046045B2 (en) 2013-12-20 2018-08-14 The Regents Of The University Of Michigan Vaccine compositions and uses thereof
FR3017714A1 (fr) * 2014-02-18 2015-08-21 Biomerieux Sa Procede et kit pour determiner la probabilite pour un patient d'evoluer vers une dengue severe
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CN108650889B (zh) * 2016-02-22 2022-06-10 欧蒙医学实验诊断股份公司 用于诊断病毒感染的免疫测定法
BR112019022384A2 (pt) 2017-04-26 2020-05-26 F. Hoffmann-La Roche Ag Polipeptídeo apropriado para detecção de anticorpos contra vírus zika, métodos de produção de polipeptídeo, de detecção de anticorpos específicos para vírus zika e de detecção de anticorpos contra vírus zika, uso de polipeptídeo do vírus zika e kit de reagentes
WO2018208741A1 (en) * 2017-05-08 2018-11-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and compositions for the detection of flavivirus infections
CN109053882B (zh) * 2018-08-28 2019-08-23 东莞市朋志生物科技有限公司 一种ns1蛋白的结合蛋白以及应用
KR102218517B1 (ko) * 2019-01-23 2021-02-19 충북대학교 산학협력단 단일클론항체 쌍을 이용한 지카 바이러스의 검출 방법
KR102218561B1 (ko) * 2019-01-28 2021-02-19 충북대학교 산학협력단 단일클론항체 쌍을 이용한 뎅기 바이러스의 검출 방법
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CN113355344B (zh) * 2021-08-10 2021-11-02 北京溯本源和生物科技有限公司 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用
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Also Published As

Publication number Publication date
US20050186562A1 (en) 2005-08-25
JP4625215B2 (ja) 2011-02-02
US20120009216A1 (en) 2012-01-12
BRPI0011369B1 (pt) 2019-03-19
EP1190257B1 (fr) 2004-08-25
ES2226894T3 (es) 2005-04-01
JP2003501661A (ja) 2003-01-14
US7670766B2 (en) 2010-03-02
US6870032B1 (en) 2005-03-22
HK1045729B (zh) 2005-03-18
US7282341B2 (en) 2007-10-16
KR20020042533A (ko) 2002-06-05
FR2794865B1 (fr) 2003-04-18
HK1045729A1 (en) 2002-12-06
AU776844B2 (en) 2004-09-23
CN1360678B (zh) 2013-07-03
US8709427B2 (en) 2014-04-29
ATE274701T1 (de) 2004-09-15
WO2000075665A1 (fr) 2000-12-14
MXPA01012662A (es) 2004-03-19
US20090226478A1 (en) 2009-09-10
CN1360678A (zh) 2002-07-24
US20090068213A1 (en) 2009-03-12
EP1190257A1 (fr) 2002-03-27
DE60013287D1 (de) 2004-09-30
PT1190257E (pt) 2004-12-31
DE60013287T2 (de) 2005-09-15
AU6447400A (en) 2000-12-28
BR0011369A (pt) 2003-08-12
FR2794865A1 (fr) 2000-12-15

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