BRPI0111682B8 - suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio - Google Patents

suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio

Info

Publication number
BRPI0111682B8
BRPI0111682B8 BRPI0111682A BR0111682A BRPI0111682B8 BR PI0111682 B8 BRPI0111682 B8 BR PI0111682B8 BR PI0111682 A BRPI0111682 A BR PI0111682A BR 0111682 A BR0111682 A BR 0111682A BR PI0111682 B8 BRPI0111682 B8 BR PI0111682B8
Authority
BR
Brazil
Prior art keywords
immunoassay support
solid immunoassay
solid
support
hcv
Prior art date
Application number
BRPI0111682A
Other languages
English (en)
Other versions
BRPI0111682B1 (pt
BR0111682A (pt
Inventor
Medina-Selby Angelica
George-Nascimento Carlos
Y Chien David
Coit Doris
Tandeske Laura
Arcangel Phillip
Original Assignee
Chiron Corp
Grifols Worldwide Operations Ltd
Novartis Vaccines & Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27395684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0111682(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp, Grifols Worldwide Operations Ltd, Novartis Vaccines & Diagnostics Inc filed Critical Chiron Corp
Publication of BR0111682A publication Critical patent/BR0111682A/pt
Publication of BRPI0111682B1 publication Critical patent/BRPI0111682B1/pt
Publication of BRPI0111682B8 publication Critical patent/BRPI0111682B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"imunoensaios para anticorpos anti-hcv". imunoensaios para anticorpos anti-hcv compreendendo um epitopo conformacional ns3/4a de hcv e um antígeno de fusão de epitopo múltiplo, são fornecidos bem como um suporte sólido para imunoensaio.
BRPI0111682A 2000-06-15 2001-06-14 suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio BRPI0111682B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21208200P 2000-06-15 2000-06-15
US60/212.082 2000-06-15
US28086701P 2001-04-02 2001-04-02
US28081101P 2001-04-02 2001-04-02
US60/280.867 2001-04-02
US60/280.811 2001-04-02
PCT/US2001/019156 WO2001096870A2 (en) 2000-06-15 2001-06-14 Immunoassays for anti-hcv antibodies

Publications (3)

Publication Number Publication Date
BR0111682A BR0111682A (pt) 2004-01-06
BRPI0111682B1 BRPI0111682B1 (pt) 2017-09-19
BRPI0111682B8 true BRPI0111682B8 (pt) 2021-07-27

Family

ID=27395684

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0111731A BRPI0111731C1 (pt) 2000-06-15 2001-06-14 suporte sólido de imunoensaio, métodos de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e de produção de um suporte sólido de imunoensaio, e, kit de teste de imunodiagnóstico
BRPI0111682A BRPI0111682B8 (pt) 2000-06-15 2001-06-14 suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0111731A BRPI0111731C1 (pt) 2000-06-15 2001-06-14 suporte sólido de imunoensaio, métodos de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e de produção de um suporte sólido de imunoensaio, e, kit de teste de imunodiagnóstico

Country Status (22)

Country Link
US (5) US6632601B2 (pt)
EP (2) EP1354204B2 (pt)
JP (3) JP4837229B2 (pt)
CN (3) CN1214244C (pt)
AT (2) ATE368221T1 (pt)
AU (2) AU2001272948A1 (pt)
BG (1) BG66205B1 (pt)
BR (2) BRPI0111731C1 (pt)
CA (2) CA2412035C (pt)
CY (2) CY1107537T1 (pt)
CZ (1) CZ304185B6 (pt)
DE (2) DE60129598T2 (pt)
DK (2) DK1354204T4 (pt)
ES (2) ES2277932T5 (pt)
HU (1) HU228873B1 (pt)
MX (2) MXPA02012424A (pt)
NO (1) NO332275B1 (pt)
PL (1) PL213363B1 (pt)
PT (2) PT1354204E (pt)
SI (1) SI1354204T2 (pt)
SK (1) SK287694B6 (pt)
WO (2) WO2001096870A2 (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510240A (ja) * 1993-05-12 1996-10-29 カイロン コーポレイション Ｃ型肝炎ウイルスｅ２／ｎｓ１領域の保存モチーフ
US7491808B2 (en) * 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
DK1354204T4 (da) * 2000-06-15 2010-06-14 Novartis Vaccines & Diagnostic HCV-antigen/antistof-kombinationssay
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
JP5175417B2 (ja) 2000-08-17 2013-04-03 トリペップ アクチ ボラゲット リバビリンを含むワクチンおよびその使用方法
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
DE10106295C1 (de) * 2001-02-02 2002-08-22 Gaifar German American Inst Fo Protein mit mehreren Antigen-Epitop-Sequenzen, welches immobilisiert ist
AU785380B2 (en) * 2001-03-28 2007-03-15 Ortho-Clinical Diagnostics, Inc. A hepatitis C antigen - antibody combination assay for the early detection of HCV infection
EP1412538B1 (en) 2001-06-26 2013-03-27 Abbott Laboratories Methods for the simultaneous detection of hcv antigens and hcv antibodies
US7101683B2 (en) 2001-06-26 2006-09-05 Abbott Laboratories Methods for the simultaneous detection of HCV antigens and HCV antibodies
US7049060B2 (en) * 2001-11-05 2006-05-23 Ortho-Clinical Diagnostics, Inc. HCV anti-core monoclonal antibodies
US7332269B2 (en) * 2001-11-11 2008-02-19 Ortho-Clinical Diagnostics, Inc. HCV core protein sequences
FR2839555B1 (fr) 2002-05-10 2007-07-27 Bio Rad Pasteur Procede de detection simultanee d'un antigene et d'un anticorps d'un microorganisme infectieux
ATE410693T1 (de) 2002-09-09 2008-10-15 Novartis Vaccines & Diagnostic Hcv-test
US20040152070A1 (en) * 2003-02-04 2004-08-05 Shah Dinesh O. Method of detection of HCV antibodies in combination assay or sole antibody assay
WO2005019828A1 (en) 2003-08-20 2005-03-03 Amorfix Life Sciences Ltd. Epitope protection assay and method for detecting protein conformations
ES2377978T3 (es) * 2004-08-27 2012-04-03 Novartis Vaccines And Diagnostics, Inc. Mutantes de proteínas no estructurales de VHC y usos de los mismos
US7658930B2 (en) * 2005-02-02 2010-02-09 Peng Cui Kit for detecting the antibody of HCV and its preparing method
CA2630220C (en) 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
US7794692B2 (en) * 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
JP5823663B2 (ja) 2006-03-03 2015-11-25 プロミス ニューロサイエンシズ インコーポレイテッド ミスフォールドｓｏｄ１媒介疾患を処置および検出するための方法および組成物
CN1908666B (zh) * 2006-08-14 2010-05-12 武汉大学 一种检测乙肝核心抗体的双夹心法酶联免疫诊断试剂盒及应用
EP2185195A2 (en) 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
EP2414839B1 (fr) * 2009-03-30 2014-06-25 Biomérieux Support solide de détection du vhc
US20100297607A1 (en) * 2009-05-20 2010-11-25 Jian Zheng Reagents For HCV Antigen-Antibody Combination Assays
BR112012025364A2 (pt) 2010-04-07 2015-09-22 Novartis Ag método para geração de partícula semelhante a vírus de parvovírus b19
EP2583101B1 (en) * 2010-06-17 2015-09-16 Koninklijke Philips N.V. Multi epitope assay
AU2011276328C1 (en) 2010-07-06 2016-01-21 Novartis Ag Norovirus derived immunogenic compositions and methods
US20120009196A1 (en) * 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
JP5911889B2 (ja) * 2011-01-13 2016-04-27 オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッドＯｒｔｈｏ−Ｃｌｉｎｉｃａｌ Ｄｉａｇｎｏｓｔｉｃｓ， Ｉｎｃ． 梅毒トレポネーマトリプレット抗原
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
BR112015023239A8 (pt) * 2013-03-14 2018-04-17 Abbott Lab ensaio de combinação de anticorpo-antígeno de hcv e métodos e composições para uso do mesmo
JP2016512241A (ja) 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 改良された抗体検出のためのｈｃｖｎｓ３組換え抗原およびこの突然変異体
CN113549148B (zh) 2013-03-14 2025-11-21 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
CN103630690B (zh) * 2013-12-17 2014-08-20 朱之炜 丙型肝炎病毒抗原抗体联合检测试剂盒及其检测方法
WO2016160046A1 (en) 2015-03-27 2016-10-06 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
WO2016172121A1 (en) * 2015-04-20 2016-10-27 Qoolabs, Inc. Camelid single-domain hcv antibodies and methods of use
CN118376776A (zh) * 2017-09-27 2024-07-23 生物辐射实验室股份有限公司 数字化亲和连接试验
CN110261616B (zh) * 2019-04-30 2021-07-20 广东菲鹏生物有限公司 一种丙型肝炎病毒检测试剂盒
CN115057943B (zh) * 2022-06-22 2025-03-14 杭州水芭莎生物医药科技有限公司 一种抗菌肽融合蛋白及其制备方法和应用
CN115838420B (zh) * 2022-10-31 2023-05-05 北京科跃中楷生物技术有限公司 一种可溶性hcv重组蛋白的制备方法及其制备的抗体检测试剂

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
GB2212511B (en) * 1987-11-18 1992-01-22 Chiron Corp Hepatitis c virus
US5350671A (en) 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
NZ227011A (en) * 1987-11-18 1992-03-26 Chiron Corp Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits
JP2730153B2 (ja) 1989-03-16 1998-03-25 日本合成ゴム株式会社 熱可塑性樹脂組成物およびその製造方法
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
DK0398748T3 (da) * 1989-05-18 2002-03-18 Chiron Corp NANBV-diagnostika: polynukleotider anvendelige til screening for hepatitis C virus
HU217025B (hu) * 1990-04-04 1999-11-29 Chiron Corp. Hepatitis C vírus-(HCV) antigénkészítmények az anti-HCV-antitestek kimutatására immunoassay-kben
US6312889B1 (en) 1990-04-04 2001-11-06 Chiron Corporation Combinations of hepatitis c virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US6194140B1 (en) * 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
PT97247B (pt) * 1991-04-03 1997-10-31 Chiron Corp Processo de preparacao de combinacoes de antigenios do virus da hepapite c (hcv) para uso em imunoensaios para anticorpos anti-hcv
WO1993000365A2 (en) 1991-06-24 1993-01-07 Chiron Corporation Hepatitis c virus (hcv) polypeptides
UA39944C2 (uk) 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
EP0651807B1 (en) * 1993-04-27 2007-09-12 N.V. Innogenetics S.A. New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
JP3217600B2 (ja) 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
US5843752A (en) 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
US5990276A (en) 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
CA2250723C (en) * 1996-05-24 2012-07-17 Chiron Corporation Multiple epitope fusion protein
US6514731B1 (en) * 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US6322965B1 (en) * 1997-02-10 2001-11-27 Advanced Life Science Institute, Inc. Chimera antigen peptide
AU9497998A (en) * 1997-09-22 1999-04-12 Chiron Corporation Method for detecting antibodies in a sample
US7316905B1 (en) * 1998-07-30 2008-01-08 Advanced Life Science Institute, Inc. Method for measurement of hepatitis C virus
DK1354204T4 (da) * 2000-06-15 2010-06-14 Novartis Vaccines & Diagnostic HCV-antigen/antistof-kombinationssay

Also Published As

Publication number Publication date
HUP0500444A3 (en) 2010-03-29
US20040096822A1 (en) 2004-05-20
DK1350105T3 (da) 2007-11-12
EP1354204A2 (en) 2003-10-22
SI1354204T2 (sl) 2010-09-30
CN100463922C (zh) 2009-02-25
NO20025878L (no) 2003-02-12
DK1354204T4 (da) 2010-06-14
BRPI0111731B8 (pt) 2016-08-23
AU2001272948A1 (en) 2001-12-24
US20020192639A1 (en) 2002-12-19
AU2001272945A1 (en) 2001-12-24
JP2011125350A (ja) 2011-06-30
US7241879B2 (en) 2007-07-10
DE60125240D1 (de) 2007-01-25
US6797809B2 (en) 2004-09-28
ATE368221T1 (de) 2007-08-15
EP1354204B1 (en) 2006-12-13
HU228873B1 (hu) 2013-06-28
BG66205B1 (bg) 2012-01-31
NO20025878D0 (no) 2002-12-06
US6630298B2 (en) 2003-10-07
NO332275B1 (no) 2012-08-13
ES2277932T5 (es) 2010-06-28
EP1350105B1 (en) 2007-07-25
CY1107537T1 (el) 2013-03-13
DE60129598T2 (de) 2008-04-17
CN1660913A (zh) 2005-08-31
MXPA02012401A (es) 2003-04-25
ES2277932T3 (es) 2007-08-01
BRPI0111731B1 (pt) 2016-07-05
WO2001096875A3 (en) 2003-08-28
ES2288969T3 (es) 2008-02-01
CA2413003C (en) 2013-08-13
CN1466682A (zh) 2004-01-07
US20040265801A1 (en) 2004-12-30
PL213363B1 (pl) 2013-02-28
US20040063092A1 (en) 2004-04-01
JP2004506878A (ja) 2004-03-04
CA2412035C (en) 2012-04-10
DE60125240T3 (de) 2010-10-28
EP1350105A2 (en) 2003-10-08
SI1354204T1 (sl) 2007-04-30
PT1350105E (pt) 2007-08-13
DK1354204T3 (da) 2007-04-10
BR0111731A (pt) 2004-02-10
ATE348337T1 (de) 2007-01-15
JP4834279B2 (ja) 2011-12-14
BG107441A (bg) 2004-01-30
BRPI0111682B1 (pt) 2017-09-19
DE60129598D1 (de) 2007-09-06
WO2001096870A2 (en) 2001-12-20
CN1489692A (zh) 2004-04-14
PT1354204E (pt) 2007-03-30
WO2001096875A2 (en) 2001-12-20
CN1214244C (zh) 2005-08-10
MXPA02012424A (es) 2003-04-25
CZ304185B6 (cs) 2013-12-11
JP2004510133A (ja) 2004-04-02
PL365599A1 (en) 2005-01-10
CA2413003A1 (en) 2001-12-20
WO2001096875A9 (en) 2002-08-15
HK1061861A1 (en) 2004-10-08
US20020146685A1 (en) 2002-10-10
SK287694B6 (sk) 2011-06-06
CY1106820T1 (el) 2012-05-23
US7319144B2 (en) 2008-01-15
HUP0500444A2 (hu) 2005-08-29
US6632601B2 (en) 2003-10-14
SK17772002A3 (sk) 2003-10-07
CN1256591C (zh) 2006-05-17
DE60125240T2 (de) 2007-07-12
HK1079796A1 (en) 2006-04-13
BR0111682A (pt) 2004-01-06
CA2412035A1 (en) 2001-12-20
BRPI0111731C1 (pt) 2021-07-27
JP4837229B2 (ja) 2011-12-14
CZ20024058A3 (cs) 2003-09-17
EP1354204B2 (en) 2010-04-21
WO2001096870A3 (en) 2003-07-31

Similar Documents

Publication Publication Date Title
BRPI0111682B8 (pt) suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio
NO923839L (no) Kombinasjoner av hepatitt c-virus(hcv)-antigener for anvendelse i immunoanalyser for anti-hcv-antistoffer
BRPI0011369B8 (pt) método de detecção precoce e kit de diagnóstico precoce de uma infecção flaviviral, processo de purificação da proteína ns1 de um flavivírus,composição imunogênca,utilização da proteína ns1,de pelo menos um anticorpo monoclonal anti-ns1 e da proteína ns1 de forma hexamérica,e, processo de expressão de um polinucleotídeo codificado para a proteína ns1 de um vírus da dengue
ATE303597T1 (de) Hcv mosaik antigen zusammensetzung
AR033448A1 (es) Prueba de combinacion antigeno-anticuerpo para hepatitis c para una deteccion temprana de la infeccion
BR0314166B8 (pt) teste de hcv
ATE174060T1 (de) Monoklonale antikörper gegen mutmassliche hepatitis c-virus ns5-proteine und ihre anwendungsmethoden
BR0206887A (pt) Reagentes para a detecção simult nea de antìgenos e anticorpos de núcleo de do vìrus da hepatite c (hcv)

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US)

Free format text: ALTERADO DE: CHIRON CORPORATION

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25C Requirement related to requested transfer of rights

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US)

Free format text: A FIM DE ATENDER A TRANSFERENCIA, REQUERIDA ATRAVES DA PETICAO NO 20140016889/RJ DE 09/05/2014, E NECESSARIO APRESENTAR O DOCUMENTO DE CESSAO COM A DEVIDA LEGALIZACAO CONSULAR.

B25A Requested transfer of rights approved

Owner name: GRIFOLS WORLDWIDE OPERATIONS LIMITED (IE)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 11, 8O C/C 13 E 25 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25G Requested change of headquarter approved

Owner name: GRIFOLS WORLDWIDE OPERATIONS LIMITED (IE)

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2001, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2674 DE 05/04/2022, POR TER SIDO INDEVIDA, EM VIRTUDE DO DESPACHO 16.3 PUBLICADO NA RPI 2638, DE 27/07/2021.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 14/06/2021