BRPI0211200B8 - peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células - Google Patents

peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células

Info

Publication number
BRPI0211200B8
BRPI0211200B8 BRPI0211200A BRPI0211200A BRPI0211200B8 BR PI0211200 B8 BRPI0211200 B8 BR PI0211200B8 BR PI0211200 A BRPI0211200 A BR PI0211200A BR PI0211200 A BRPI0211200 A BR PI0211200A BR PI0211200 B8 BRPI0211200 B8 BR PI0211200B8
Authority
BR
Brazil
Prior art keywords
destruction
removal
cells
tumors
require
Prior art date
Application number
BRPI0211200A
Other languages
English (en)
Inventor
Gemmell Jack
A Averback Paul
Original Assignee
Nymox Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nymox Corp filed Critical Nymox Corp
Publication of BR0211200A publication Critical patent/BR0211200A/pt
Publication of BRPI0211200B1 publication Critical patent/BRPI0211200B1/pt
Publication of BRPI0211200B8 publication Critical patent/BRPI0211200B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Dermatology (AREA)
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  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • Zoology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

"peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células". a presente invenção é relacionada a peptídeos, composições e a métodos de tratamento de condições que requerem remoção ou destruição de células danosas ou indesejadas em um paciente, tal como tumores benignos e malignos, utilizando proteínas (e peptídeos derivados de seqüência de amino ácidos de tais proteínas), as seqüências de amino ácidos as quais incluem pelo menos uma sequência de amino ácido derivada de proteínas em cadeia neural e outras moléculas relacionadas.
BRPI0211200A 2001-07-19 2002-07-19 peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células BRPI0211200B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30615001P 2001-07-19 2001-07-19
US30616101P 2001-07-19 2001-07-19
US60/306,150 2001-07-19
US60/306,161 2001-07-19
US33147701P 2001-11-16 2001-11-16
US60/331,477 2001-11-16
PCT/CA2002/001106 WO2003008444A2 (en) 2001-07-19 2002-07-19 Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells

Publications (3)

Publication Number Publication Date
BR0211200A BR0211200A (pt) 2004-09-28
BRPI0211200B1 BRPI0211200B1 (pt) 2020-03-17
BRPI0211200B8 true BRPI0211200B8 (pt) 2021-07-27

Family

ID=27405149

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0211199-3A BR0211199A (pt) 2001-07-19 2002-07-19 Peptìdeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células
BRPI0211200A BRPI0211200B8 (pt) 2001-07-19 2002-07-19 peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0211199-3A BR0211199A (pt) 2001-07-19 2002-07-19 Peptìdeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células

Country Status (22)

Country Link
US (2) US7192929B2 (pt)
EP (2) EP1417227B1 (pt)
JP (4) JP2005507647A (pt)
KR (2) KR101005130B1 (pt)
CN (1) CN100475843C (pt)
AT (1) ATE353914T1 (pt)
AU (2) AU2002319049B2 (pt)
BR (2) BR0211199A (pt)
CA (2) CA2453965C (pt)
CY (1) CY1108009T1 (pt)
DE (2) DE60218179T2 (pt)
DK (1) DK1417228T3 (pt)
EA (1) EA006603B1 (pt)
ES (2) ES2281529T3 (pt)
IL (2) IL159903A0 (pt)
MX (1) MXPA04000561A (pt)
NO (1) NO333999B1 (pt)
NZ (2) NZ531115A (pt)
PL (1) PL207588B1 (pt)
PT (1) PT1417228E (pt)
WO (2) WO2003008443A2 (pt)
ZA (1) ZA200401320B (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245451A1 (en) * 2000-04-05 2005-11-03 Pincus Matthew R Peptides selectively lethal to malignant and transformed mammalian cells
AU2002304314B2 (en) * 2001-03-08 2007-09-06 Nyomox Pharmaceutical Corporation Using neural thread proteins to treat tumors and other hyperproliferative disorders
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
ES2281529T3 (es) * 2001-07-19 2007-10-01 Nymox Corporation Peptidos eficaces en el tratamiento de tumores y otras afecciones que requieren la eliminacion o destruccion de celulas.
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
WO2003048188A2 (en) * 2001-12-04 2003-06-12 Millennium Pharmaceuticals, Inc. 15603, a human ion channel family member
EP1646648A2 (en) * 2003-07-15 2006-04-19 Genova Ltd. Secreted polypeptide species reduced in cardiovascular disorders
CN1822853A (zh) * 2003-07-15 2006-08-23 加拿大国家研究委员会 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物
US20050226883A1 (en) * 2004-02-06 2005-10-13 Paul Averback Humanized antibody
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
CN101389760A (zh) 2006-02-28 2009-03-18 尼莫克斯股份有限公司 有效治疗肿瘤或其他需要除去或破坏细胞的病症的肽
CA2643239A1 (en) * 2006-03-10 2007-09-20 Nymox Corporation Method of preventing or reducing the risk or incidence of cancer using neural thread protein based peptides
US20080027005A1 (en) * 2006-07-31 2008-01-31 Paul Averback Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
JP5572938B2 (ja) * 2007-10-25 2014-08-20 東レ株式会社 免疫誘導剤
CN104906597B (zh) * 2007-10-25 2018-07-10 东丽株式会社 免疫诱导剂
WO2009070650A1 (en) * 2007-11-26 2009-06-04 The Research Foundation Of State University Of New York Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells
RU2545347C2 (ru) * 2008-04-24 2015-03-27 Теримьюнекс Фармасьютикалз, Инк. Пептидил-диацилглицериды
EP2621526B1 (en) 2010-09-29 2018-06-06 Agensys, Inc. Antibody drug conjugates (adc) that bind to 191p4d12 proteins
MX2016005614A (es) 2013-11-01 2016-12-09 Spherium Biomed S L Cuerpos de inclusion para el suministro transdermico de agentes terapeuticos y cosmeticos.
US20160215031A1 (en) * 2015-01-27 2016-07-28 Nymox Pharnaceutical Corporation Method of treating disorders requiring destruction or removal of cells
US20160361380A1 (en) * 2015-06-12 2016-12-15 Nymox Corporation Combination compositions for treating disorders requiring removal or destruction of unwanted cellular proliferations
US11628202B2 (en) * 2015-07-24 2023-04-18 Nymox Corporation Methods of reducing the need for surgery in patients suffering from benign prostatic hyperplasia
US10183058B2 (en) 2016-06-17 2019-01-22 Nymox Corporation Method of preventing or reducing the progression of prostate cancer
US10172910B2 (en) 2016-07-28 2019-01-08 Nymox Corporation Method of preventing or reducing the incidence of acute urinary retention
US10532081B2 (en) 2016-09-07 2020-01-14 Nymox Corporation Method of ameliorating or preventing the worsening or the progression of symptoms of BPH
US10335453B2 (en) 2017-03-01 2019-07-02 Nymox Corporation Compositions and methods for improving sexual function
US10835538B2 (en) 2018-03-28 2020-11-17 Nymox Corporation Method of treating benign prostatic hyperlasia with antibiotics
WO2019195851A1 (en) 2018-04-06 2019-10-10 Oncolyze, Inc. Compositions for use in lysis of selective cancer cells
US20200061150A1 (en) 2018-08-23 2020-02-27 Nymox Corporation Method of inducing selective prostate glandular pharmaco-ablation with sparing of nerves and preservation of sexual function
US12257340B2 (en) 2018-12-03 2025-03-25 Agensys, Inc. Pharmaceutical compositions comprising anti-191P4D12 antibody drug conjugates and methods of use thereof
US11278588B2 (en) 2019-05-13 2022-03-22 Nymox Corporation Method of treating lower urinary tract symptoms with fexapotide triflutate
US11298400B2 (en) 2019-05-13 2022-04-12 Nymox Corporation Method of enhancing the therapeutic efficacy of fexapotide triflutate in treating LUTS
US20200360466A1 (en) 2019-05-13 2020-11-19 Nymox Corporation Method of improving lower urinary tract symptoms
US11331374B2 (en) 2019-07-31 2022-05-17 Nymox Corporation Focal treatment of prostate cancer
US11231421B2 (en) 2019-07-31 2022-01-25 Nymox Corporation Methods of treating multifocal cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2094733T3 (es) * 1988-12-21 1997-02-01 Gen Hospital Corp Deteccion de enfermedades o disfunciones neurologicas.
US5948634A (en) * 1988-12-21 1999-09-07 The General Hospital Coporation Neural thread protein gene expression and detection of alzheimer's disease
NZ337445A (en) * 1997-02-26 2000-12-22 Gen Hospital Corp Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
WO2000000157A2 (en) * 1998-06-26 2000-01-06 Georgetown University Medical Center Use of tempo and tempo derivatives for inducing cell death
AU2185199A (en) * 1998-09-30 2000-04-17 Yoko Aida Apoptosis inducers
CA2353797A1 (en) * 1998-12-11 2000-06-15 Incyte Pharmaceuticals, Inc. Neuron-associated proteins
EA200100770A1 (ru) * 1999-01-11 2002-02-28 Леадд Б.В. Применение агентов, индуцирующих апоптоз, в лечении (ауто)имунных заболеваний
WO2000058495A1 (en) 1999-03-26 2000-10-05 Human Genome Sciences, Inc. 45 human secreted proteins
CA2364630A1 (en) 1999-03-12 2000-09-21 Human Genome Sciences, Inc. 50 human secreted proteins
CA2365223A1 (en) * 1999-03-19 2000-09-28 Craig A. Rosen 46 human secreted proteins
EP1171462A2 (en) * 1999-03-26 2002-01-16 Human Genome Sciences, Inc. 49 human secreted proteins
CA2368281A1 (en) * 1999-03-26 2000-10-05 Craig A. Rosen 50 human secreted proteins
CN1300779A (zh) * 1999-12-22 2001-06-27 上海博德基因开发有限公司 一种新的多肽－人神经元线蛋白17和编码这种多肽的多核苷酸
CN1300783A (zh) * 1999-12-23 2001-06-27 上海生元基因开发有限公司 新的人神经元线蛋白及其编码序列
US20020127671A1 (en) * 2000-06-26 2002-09-12 Curtis Rory A.J. 52927, a novel human calcium channel and uses thereof
CN1352145A (zh) * 2000-11-10 2002-06-05 上海博德基因开发有限公司 一种新的多肽——锌指蛋白14.08和编码这种多肽的多核苷酸
US6783969B1 (en) * 2001-03-05 2004-08-31 Nuvelo, Inc. Cathepsin V-like polypeptides
KR100945383B1 (ko) 2001-05-25 2010-03-05 니목스 코포레이션 종양 및 세포의 제거 또는 파괴를 필요로 하는 다른질환의 치료에 효과적인 펩티드
ES2281529T3 (es) * 2001-07-19 2007-10-01 Nymox Corporation Peptidos eficaces en el tratamiento de tumores y otras afecciones que requieren la eliminacion o destruccion de celulas.

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PL368912A1 (en) 2005-04-04
CA2453967A1 (en) 2003-01-30
AU2002319050B2 (en) 2008-09-11
ES2281528T3 (es) 2007-10-01
ES2281529T3 (es) 2007-10-01
CA2453967C (en) 2014-01-07
NO20040222L (no) 2004-03-19
EP1417227B1 (en) 2007-01-10
NZ531114A (en) 2006-12-22
NO333999B1 (no) 2013-11-11
US20030109437A1 (en) 2003-06-12
MXPA04000561A (es) 2005-02-17
KR101005130B1 (ko) 2011-01-04
AU2002319049B2 (en) 2007-10-25
US7192929B2 (en) 2007-03-20
EP1417227A2 (en) 2004-05-12
WO2003008443A2 (en) 2003-01-30
BRPI0211200B1 (pt) 2020-03-17
JP5622885B2 (ja) 2014-11-12
DE60217507D1 (de) 2007-02-22
JP2005506061A (ja) 2005-03-03
NZ531115A (en) 2005-03-24
US7241738B2 (en) 2007-07-10
IL159903A (en) 2010-02-17
CA2453965A1 (en) 2003-01-30
DE60218179D1 (de) 2007-03-29
EA200400205A1 (ru) 2004-06-24
JP2011152133A (ja) 2011-08-11
BR0211199A (pt) 2004-10-26
KR20040026686A (ko) 2004-03-31
WO2003008444A3 (en) 2003-11-20
ATE353914T1 (de) 2007-03-15
DE60217507T2 (de) 2007-11-15
DK1417228T3 (da) 2007-06-04
CN1649895A (zh) 2005-08-03
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US20030096756A1 (en) 2003-05-22
EP1417228B1 (en) 2007-02-14
JP2013215191A (ja) 2013-10-24
EA006603B1 (ru) 2006-02-24
KR100966232B1 (ko) 2010-06-25
WO2003008443A3 (en) 2003-11-27
DE60218179T2 (de) 2007-11-22
ZA200401320B (en) 2005-01-26
CN100475843C (zh) 2009-04-08
PT1417228E (pt) 2007-05-31
KR20040018481A (ko) 2004-03-03
IL159903A0 (en) 2004-06-20
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