BRPI0212215B8 - compostos de ciclopenta[g]quinazolina anticâncer, uso dos mesmos para o tratamento de câncer e composição farmacêutica compreendendo dito composto - Google Patents

compostos de ciclopenta[g]quinazolina anticâncer, uso dos mesmos para o tratamento de câncer e composição farmacêutica compreendendo dito composto

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Publication number
BRPI0212215B8
BRPI0212215B8 BRPI0212215A BRPI0212215A BRPI0212215B8 BR PI0212215 B8 BRPI0212215 B8 BR PI0212215B8 BR PI0212215 A BRPI0212215 A BR PI0212215A BR PI0212215 A BRPI0212215 A BR PI0212215A BR PI0212215 B8 BRPI0212215 B8 BR PI0212215B8
Authority
BR
Brazil
Prior art keywords
cyclopenta
alkyl
quinazoline
cancer
compound
Prior art date
Application number
BRPI0212215A
Other languages
English (en)
Inventor
Lesley Jackman Ann
Bavetsias Vassilios
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121151A external-priority patent/GB0121151D0/en
Priority claimed from GB0129387A external-priority patent/GB0129387D0/en
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Publication of BR0212215A publication Critical patent/BR0212215A/pt
Publication of BRPI0212215B1 publication Critical patent/BRPI0212215B1/pt
Publication of BRPI0212215B8 publication Critical patent/BRPI0212215B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

compostos de ciclopenta [g] quinazolina anticâncer. as ciclopenta [g] quinazolinas da fórmula (i) : - em que: a é um grupo or ou nr0r1 em que r0 e r1 são cada um independentemente hidrogênio, alquila de c1-4, alquenila de c3-c4, alquinila de c3-4, hidróxialquila de c2-4, halogenoalquila de c2-4 ou cianoalquila de c1-4, ou r0 e r1 juntamente com o n intermediário formam um anel heterocíclico de cinco ou seis elementos; p é um número inteiro na faixa 1 a 4; r2 é hidrogênio, alquila de c1-4, alquenila de c3-4, alquinila de c3-4, hidróxialquila de c2-4, halogenoalquila de c2-4 ou cianoalquila de c1-4; ar1 é fenileno, tiofenodiíla, tiazoldiíla, piridinadiíla ou pirimidinadiíla que pode opcionalmente conter um ou dois substituintes selecionados a partir de halogeno, hidróxi, amino, nitro, ciano, triflúormetila, alquila de c1-4 e alcóxi de c1-4; e r3 é um grupo de uma das seguintes fórmulas: -a1-ar2-a2 -y1, -a5-con (r) ch (y4) y5, -a8-x-ar4, e os seus sais ou ésteres farmaceuticamente aceitáveis são de valor terapêutico, particularmente no tratamento de câncer.
BRPI0212215A 2001-08-31 2002-08-30 compostos de ciclopenta[g]quinazolina anticâncer, uso dos mesmos para o tratamento de câncer e composição farmacêutica compreendendo dito composto BRPI0212215B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0121151.5 2001-08-31
GB0121151A GB0121151D0 (en) 2001-08-31 2001-08-31 Anti-cancer compounds
GB0129387.7 2001-12-07
GB0129387A GB0129387D0 (en) 2001-12-07 2001-12-07 Anti-cancer compounds
US34025301P 2001-12-18 2001-12-18
US60/340,253 2001-12-18
PCT/GB2002/003979 WO2003020748A1 (en) 2001-08-31 2002-08-30 Anti-cancer cyclopenta[g]quinazoline compounds

Publications (3)

Publication Number Publication Date
BR0212215A BR0212215A (pt) 2004-09-21
BRPI0212215B1 BRPI0212215B1 (pt) 2019-02-19
BRPI0212215B8 true BRPI0212215B8 (pt) 2021-07-27

Family

ID=27256270

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0212215A BRPI0212215B8 (pt) 2001-08-31 2002-08-30 compostos de ciclopenta[g]quinazolina anticâncer, uso dos mesmos para o tratamento de câncer e composição farmacêutica compreendendo dito composto

Country Status (15)

Country Link
US (6) US7297701B2 (pt)
EP (3) EP2332962A1 (pt)
JP (1) JP4328202B2 (pt)
KR (2) KR100983962B1 (pt)
AT (1) ATE483722T1 (pt)
AU (1) AU2002321576B2 (pt)
BR (1) BRPI0212215B8 (pt)
CA (1) CA2458813C (pt)
CY (1) CY1111078T1 (pt)
DE (1) DE60237902D1 (pt)
DK (1) DK1421105T3 (pt)
MX (1) MXPA04001905A (pt)
PT (1) PT1421105E (pt)
WO (1) WO2003020748A1 (pt)
ZA (1) ZA200401587B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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KR100983962B1 (ko) * 2001-08-31 2010-09-27 비티지 인터내셔널 리미티드 항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
CA2655933C (en) 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
CN101977620B (zh) * 2008-03-18 2014-05-07 英国技术集团国际有限公司 用于治疗类风湿性关节炎或急性骨髓性白血病的环戊二烯并[g]喹唑啉衍生物
KR20110084280A (ko) 2008-11-03 2011-07-21 알레시아 바이오쎄라퓨틱스 인코포레이티드 종양 항원의 생물 활성을 특이적으로 차단하는 항체
US8809526B2 (en) * 2010-07-19 2014-08-19 Onyx Pharmaceuticals, Inc. Synthesis of cyclopentaquinazolines
CN103748106A (zh) * 2010-12-22 2014-04-23 奥尼克斯医药品股份有限公司 有效的肽偶联及其在环戊二烯并[g]喹唑啉三钠盐的合成和分离中的用途
RS59080B1 (sr) 2011-03-31 2019-09-30 Adc Therapeutics Sa Antitela protiv antigena 1 povezanog sa bubrezima i njihovi fragmenti koji se vezuju za antigen
HRP20190946T1 (hr) 2012-01-09 2019-07-26 Adc Therapeutics Sa Sredstva za liječenje trostruko negativnog raka dojke
GB201707864D0 (en) * 2017-05-16 2017-06-28 Inst Of Cancer Research: Royal Cancer Hospital Platinum-reistant cancer treatment

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DE3069468D1 (en) 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
GB9205320D0 (en) 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
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KR100983962B1 (ko) * 2001-08-31 2010-09-27 비티지 인터내셔널 리미티드 항암제로서 사용되는 시클로펜타[ｇ]퀴나졸린 화합물
KR100568546B1 (ko) * 2004-10-19 2006-04-07 삼성전자주식회사 메모리 시스템, 반도체 메모리 장치, 및 이 시스템과장치의 출력 데이터 스트로우브 신호 발생 방법
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Also Published As

Publication number Publication date
BRPI0212215B1 (pt) 2019-02-19
US7863284B2 (en) 2011-01-04
PT1421105E (pt) 2010-12-07
US20100056551A1 (en) 2010-03-04
DK1421105T3 (da) 2010-11-29
BR0212215A (pt) 2004-09-21
US20100273817A1 (en) 2010-10-28
CA2458813A1 (en) 2003-03-13
CA2458813C (en) 2011-11-01
ATE483722T1 (de) 2010-10-15
US7297701B2 (en) 2007-11-20
WO2003020748A1 (en) 2003-03-13
ZA200401587B (en) 2005-05-25
US20100216824A1 (en) 2010-08-26
DE60237902D1 (de) 2010-11-18
US7705006B2 (en) 2010-04-27
AU2002321576B2 (en) 2008-09-11
MXPA04001905A (es) 2005-04-19
EP1421105A1 (en) 2004-05-26
US8552016B2 (en) 2013-10-08
EP2311850A1 (en) 2011-04-20
KR20100043294A (ko) 2010-04-28
US8063056B2 (en) 2011-11-22
US20080015206A1 (en) 2008-01-17
US8486955B2 (en) 2013-07-16
JP4328202B2 (ja) 2009-09-09
KR20040044511A (ko) 2004-05-28
EP1421105B1 (en) 2010-10-06
CY1111078T1 (el) 2015-06-11
US20040242606A1 (en) 2004-12-02
KR100983962B1 (ko) 2010-09-27
JP2005509600A (ja) 2005-04-14
US20090023760A1 (en) 2009-01-22
EP2332962A1 (en) 2011-06-15

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