BRPI0213844B8 - anticorpo monoclonal humanizado purificado, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr4, para tratar um paciente com câncer, para tratar um paciente tendo uma doença inflamatória ou autoimune - Google Patents

anticorpo monoclonal humanizado purificado, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr4, para tratar um paciente com câncer, para tratar um paciente tendo uma doença inflamatória ou autoimune

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Publication number
BRPI0213844B8
BRPI0213844B8 BRPI0213844A BR0213844A BRPI0213844B8 BR PI0213844 B8 BRPI0213844 B8 BR PI0213844B8 BR PI0213844 A BRPI0213844 A BR PI0213844A BR 0213844 A BR0213844 A BR 0213844A BR PI0213844 B8 BRPI0213844 B8 BR PI0213844B8
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BR
Brazil
Prior art keywords
target cells
treat
expressing target
patient
proliferation
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BRPI0213844A
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English (en)
Other versions
BRPI0213844B1 (pt
BR0213844A (pt
Inventor
F Lobuglio Albert
J Buchsbaum Donald
P Kimberly Robert
Zhou Tong
J Koopman William
Original Assignee
Uab Research Foundation
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Publication of BR0213844A publication Critical patent/BR0213844A/pt
Publication of BRPI0213844B1 publication Critical patent/BRPI0213844B1/pt
Publication of BRPI0213844B8 publication Critical patent/BRPI0213844B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
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Abstract

"anticorpo purificado que se liga especificamente a um receptor dr-4 do trail, anticorpo monoclonal, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr-4, para tratar um paciente com câncer, e um paciente tendo uma doença inflamatória ou auto-imune, ácido nucleico isolado, vetor, celula cultivada, e polipeptídeo purificado. um anticorpo da invenção interage com a dr5 humana ou com a dr4 humana para produzir efeitos agonísticos ou antagonísticos a jusante do receptor incluindo a inibição da proliferação celular e apoptose. as seqüências de ácido nucleico e seqüências de aminoácido dos anticorpos de dr5 e dr4 foram elucidadas e vetores e células que contêm e que expressam estas seqüências foram gerados. as composições que se utilizam dos anticorpos estão detalhadas incluindo composições para o tratamento de doença relacionada com a apoptose e o tratamento do desenvolvimento celular desregulado.
BRPI0213844A 2001-11-01 2002-11-01 anticorpo monoclonal humanizado purificado, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr4, para tratar um paciente com câncer, para tratar um paciente tendo uma doença inflamatória ou autoimune BRPI0213844B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34640201P 2001-11-01 2001-11-01
PCT/US2002/035333 WO2003037913A2 (en) 2001-11-01 2002-11-01 An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

Publications (3)

Publication Number Publication Date
BR0213844A BR0213844A (pt) 2006-05-23
BRPI0213844B1 BRPI0213844B1 (pt) 2018-12-26
BRPI0213844B8 true BRPI0213844B8 (pt) 2021-05-25

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ID=23359208

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Application Number Title Priority Date Filing Date
BRPI0213844A BRPI0213844B8 (pt) 2001-11-01 2002-11-01 anticorpo monoclonal humanizado purificado, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr4, para tratar um paciente com câncer, para tratar um paciente tendo uma doença inflamatória ou autoimune

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EP (2) EP1506011B1 (pt)
JP (1) JP4371814B2 (pt)
KR (1) KR101004098B1 (pt)
CN (1) CN100482276C (pt)
AU (1) AU2002350121B2 (pt)
BR (1) BRPI0213844B8 (pt)
CA (1) CA2465040C (pt)
CO (1) CO5580833A2 (pt)
ES (1) ES2357225T3 (pt)
HU (1) HUP0700077A3 (pt)
IL (3) IL161685A0 (pt)
MX (1) MXPA04004185A (pt)
NO (1) NO338458B1 (pt)
NZ (1) NZ532591A (pt)
PL (1) PL211755B1 (pt)
RO (1) RO123115B1 (pt)
RU (1) RU2313537C2 (pt)
WO (1) WO2003037913A2 (pt)
ZA (2) ZA200403116B (pt)

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KR101004098B1 (ko) 2011-01-13
WO2003037913A3 (en) 2004-11-18
NZ532591A (en) 2008-04-30
ZA200507050B (en) 2010-03-31
EP2287285A3 (en) 2012-05-02
PL211755B1 (pl) 2012-06-29
ES2357225T3 (es) 2011-04-20
RU2004116475A (ru) 2005-04-20
IL161685A0 (en) 2004-09-27
ZA200403116B (en) 2006-06-28
EP1506011A4 (en) 2006-07-12
CN1655814A (zh) 2005-08-17
KR20040070349A (ko) 2004-08-07
MXPA04004185A (es) 2005-05-16
JP2005509414A (ja) 2005-04-14
BRPI0213844B1 (pt) 2018-12-26
RO123115B1 (ro) 2010-11-30
IL161685A (en) 2011-03-31
EP2287285A2 (en) 2011-02-23
BR0213844A (pt) 2006-05-23
PL373531A1 (en) 2005-09-05
HUP0700077A3 (en) 2012-09-28
RU2313537C2 (ru) 2007-12-27
CO5580833A2 (es) 2005-11-30
NO20042269L (no) 2004-06-30
CN100482276C (zh) 2009-04-29
CA2465040A1 (en) 2003-05-08
EP1506011B1 (en) 2015-08-19
JP4371814B2 (ja) 2009-11-25
CA2465040C (en) 2013-12-10
EP1506011A2 (en) 2005-02-16
HUP0700077A2 (en) 2007-05-02
IL196082A (en) 2011-04-28
WO2003037913A2 (en) 2003-05-08
NO338458B1 (no) 2016-08-15
AU2002350121B2 (en) 2007-09-06

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