BRPI0615997A8 - método para prever a sensibilidade de uma amostra de célula ou tecido, método para induzir apoptose em uma amostra de célula ou tecido e método de tratamento de uma disfunção - Google Patents

método para prever a sensibilidade de uma amostra de célula ou tecido, método para induzir apoptose em uma amostra de célula ou tecido e método de tratamento de uma disfunção

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Publication number
BRPI0615997A8
BRPI0615997A8 BRPI0615997A BRPI0615997A BRPI0615997A8 BR PI0615997 A8 BRPI0615997 A8 BR PI0615997A8 BR PI0615997 A BRPI0615997 A BR PI0615997A BR PI0615997 A BRPI0615997 A BR PI0615997A BR PI0615997 A8 BRPI0615997 A8 BR PI0615997A8
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BR
Brazil
Prior art keywords
cell
tissue sample
dysfunction
treating
predicting
Prior art date
Application number
BRPI0615997A
Other languages
English (en)
Inventor
J Ashkenazi Avi
W Wagner Klaus
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BRPI0615997A2 publication Critical patent/BRPI0615997A2/pt
Publication of BRPI0615997A8 publication Critical patent/BRPI0615997A8/pt

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Abstract

método para prever a sensibilidade de uma amostra de célula ou tecido, método para induzir apoptose em uma amostra de célula ou tecido, método de tratamento de uma disfunção e uso de apo2l/trail a presente invenção refere-se a métodos e testes que examinam expressão de um ou mais biomarcadores em uma amostra de célula ou tecido de mamífero. de acordo com os métodos e testes divulgados, a detecção da expressão de moléculas relacionadas à galnac-t, tais como galnac-t14 ou galnac-t3, é preditiva ou indicativa de que a amostra de célula ou tecido será sensível a agentes de indução de apoptose tais como apo2litrail e anticorpos agonistas de anti-dr5. kits e artigos de fabricação são também fornecidos.
BRPI0615997A 2005-08-16 2006-08-15 método para prever a sensibilidade de uma amostra de célula ou tecido, método para induzir apoptose em uma amostra de célula ou tecido e método de tratamento de uma disfunção BRPI0615997A8 (pt)

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US70867705P 2005-08-16 2005-08-16
US60/708,677 2005-08-16
US80807606P 2006-05-24 2006-05-24
US60/808,076 2006-05-24
PCT/US2006/031785 WO2007022157A2 (en) 2005-08-16 2006-08-15 Apoptosis sensitivity to ap02l/trail by testing for 'galnac-t14 expression in cells/tissues

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BRPI0615997A2 BRPI0615997A2 (pt) 2011-05-31
BRPI0615997A8 true BRPI0615997A8 (pt) 2018-05-22

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BRPI0616005-0A BRPI0616005A2 (pt) 2005-08-16 2006-08-15 método para prever a sensibilidade de uma amostra de célula ou tecido, método para induzir apoptose em uma amostra de célula ou tecido e método de tratamento de uma disfunção

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ZA200800974B (en) 2009-11-25
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JP5186372B2 (ja) 2013-04-17
RU2010144511A (ru) 2012-05-10
US20130072429A1 (en) 2013-03-21
JP2011250788A (ja) 2011-12-15
IL188874A0 (en) 2008-04-13
RU2008110078A (ru) 2009-09-27
PT1915626E (pt) 2012-02-03
WO2007022214A3 (en) 2007-08-23
EP1915625A2 (en) 2008-04-30
RU2409817C2 (ru) 2011-01-20
BRPI0615997A2 (pt) 2011-05-31
IL188874A (en) 2012-10-31
HK1115638A1 (en) 2008-12-05
ZA200800969B (en) 2009-08-26
KR100990273B1 (ko) 2010-10-26
CN101365951B (zh) 2013-09-11
EP1915626B1 (en) 2011-11-09
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US20080182277A1 (en) 2008-07-31
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CA2619842A1 (en) 2007-02-22
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JP2017129589A (ja) 2017-07-27
JP2011244824A (ja) 2011-12-08
AU2010246471A1 (en) 2010-12-16
DK1915626T3 (da) 2012-02-13
WO2007022157A2 (en) 2007-02-22
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