BRPI0215485B8 - compostos de geranila, agente antitumoral, composição farmacêutica, e, uso de um composto de geranila - Google Patents

compostos de geranila, agente antitumoral, composição farmacêutica, e, uso de um composto de geranila

Info

Publication number
BRPI0215485B8
BRPI0215485B8 BRPI0215485A BR0215485A BRPI0215485B8 BR PI0215485 B8 BRPI0215485 B8 BR PI0215485B8 BR PI0215485 A BRPI0215485 A BR PI0215485A BR 0215485 A BR0215485 A BR 0215485A BR PI0215485 B8 BRPI0215485 B8 BR PI0215485B8
Authority
BR
Brazil
Prior art keywords
geranil
formula
image
compounds
compound
Prior art date
Application number
BRPI0215485A
Other languages
English (en)
Other versions
BRPI0215485B1 (pt
BR0215485A (pt
Inventor
Akiyama Kiyoshi
Original Assignee
Ohgen Res Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002004136A external-priority patent/JP4109453B2/ja
Priority claimed from JP2002004123A external-priority patent/JP4010814B2/ja
Priority claimed from JP2002283644A external-priority patent/JP3989808B2/ja
Application filed by Ohgen Res Laboratories Ltd filed Critical Ohgen Res Laboratories Ltd
Publication of BR0215485A publication Critical patent/BR0215485A/pt
Publication of BRPI0215485B1 publication Critical patent/BRPI0215485B1/pt
Publication of BRPI0215485B8 publication Critical patent/BRPI0215485B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/02—Thiols having mercapto groups bound to acyclic carbon atoms
    • C07C321/08—Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"compostos de geranila, derivados do ácido mevalônico, agente antitumoral, composição farmacêutica, processo de tratamento de câncer, e, uso de um composto de geranila". esta invenção fornece compostos que têm excelente atividade antitumoral, que são representados pelas fórmulas a seguir: em que r^ 1^, r^ 2^, r^ 3^, m, n e r^ 4^ têm os significados como fornecidos no relatório descritivo.
BRPI0215485A 2002-01-11 2002-12-26 compostos de geranila, agente antitumoral, composição farmacêutica, e, uso de um composto de geranila BRPI0215485B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2002004131 2002-01-11
JP2002004136A JP4109453B2 (ja) 2002-01-11 2002-01-11 ゲラニル基含有アミド誘導体
JP2002004123A JP4010814B2 (ja) 2002-01-11 2002-01-11 メバロン酸誘導体
JP2002283644A JP3989808B2 (ja) 2002-01-11 2002-09-27 ゲラニル−糖誘導体
PCT/JP2002/013615 WO2003059866A1 (en) 2002-01-11 2002-12-26 Geranyl compounds

Publications (3)

Publication Number Publication Date
BR0215485A BR0215485A (pt) 2004-12-28
BRPI0215485B1 BRPI0215485B1 (pt) 2016-07-19
BRPI0215485B8 true BRPI0215485B8 (pt) 2021-05-25

Family

ID=27482764

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0215485A BRPI0215485B8 (pt) 2002-01-11 2002-12-26 compostos de geranila, agente antitumoral, composição farmacêutica, e, uso de um composto de geranila

Country Status (12)

Country Link
US (4) US7125852B2 (pt)
EP (4) EP2399899B1 (pt)
KR (4) KR100946603B1 (pt)
CN (1) CN1307148C (pt)
AT (1) ATE519733T1 (pt)
AU (1) AU2002361126C1 (pt)
BR (1) BRPI0215485B8 (pt)
CA (4) CA2706826C (pt)
MX (1) MXPA04006636A (pt)
TW (1) TWI230162B (pt)
WO (1) WO2003059866A1 (pt)
ZA (1) ZA200404877B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008272854B2 (en) * 2007-07-03 2014-03-13 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
WO2009111648A1 (en) * 2008-03-05 2009-09-11 Vicus Therapeutics, Llc Compositions and methods for mucositis and oncology therapies
EP2280934A2 (en) 2008-04-09 2011-02-09 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Fatty acid amides and uses thereof
DE102008042421A1 (de) * 2008-09-26 2010-04-01 Symrise Gmbh & Co. Kg Geranylaminderivate der Oxalsäure
GB0902849D0 (en) 2009-02-19 2009-04-08 Givaudan Sa Organic compounds
CN104219964B (zh) 2012-03-30 2016-09-21 奇华顿股份有限公司 作为食品加香化合物的n-酰基脯氨酸衍生物
EP2830437B1 (en) 2012-03-30 2018-12-26 Givaudan SA N-acylated 1-aminocycloalkyl carboxylic acids as food flavouring compounds
CN104219966B (zh) 2012-03-30 2019-05-28 奇华顿股份有限公司 作为食品加香化合物的n-酰基-氨基酸衍生物
CN104254253B (zh) 2012-03-30 2017-12-29 奇华顿股份有限公司 作为食品加香化合物的n‑酰化甲硫氨酸衍生物
CA2867316C (en) 2012-03-30 2019-10-29 Givaudan S.A. N-acyl derivatives of gamma amino-butyric acid and beta alanine as food flavouring compounds
JP6452201B2 (ja) 2012-03-30 2019-01-16 ジボダン エス エー 食品フレーバー付与化合物としてのｎ−アシル−アミノ酸誘導体、それらを含有する粉末組成物
EP2830439B1 (en) 2012-03-30 2020-11-04 Givaudan SA N-acyl-gaba derivatives for the improvement of the flavour profile of edible compositions
WO2013157926A1 (en) * 2012-04-19 2013-10-24 Nyken Holding B.V. Geranyl geranyl acetone analogs and uses thereof
US10834950B2 (en) 2013-10-02 2020-11-17 Givaudan S.A. Organic compounds
WO2015048991A1 (en) * 2013-10-02 2015-04-09 Givaudan Sa Organic compounds having taste-modifying properties
GB201317424D0 (en) 2013-10-02 2013-11-13 Givaudan Sa Improvements in or relating to organic compounds
WO2015050535A1 (en) 2013-10-02 2015-04-09 Givaudan S.A. Organic compounds
WO2015050537A1 (en) 2013-10-02 2015-04-09 Givaudan S.A. Organic compounds
US10674755B2 (en) 2013-10-02 2020-06-09 Givaudan S.A. Organic Compounds
EP3052472B1 (en) 2013-10-02 2019-02-27 Givaudan S.A. N-acylated 2-aminoisobutyric acid compounds and flavour compositions containing them
WO2015048990A1 (en) 2013-10-02 2015-04-09 Givaudan Sa Organic compounds having taste-modifying properties
WO2016077555A1 (en) * 2014-11-12 2016-05-19 Visolis, Inc. Polymers prepared from mevalonolactone and derivatives
US9889120B2 (en) 2016-01-14 2018-02-13 Vicus Therapeutics, Llc Combination drug therapies for cancer and methods of making and using them
JP2024503174A (ja) * 2020-08-06 2024-01-25 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム リミテッド オレイルシステインアミドまたはその誘導体及び治療におけるその使用
JP7339574B2 (ja) * 2021-06-22 2023-09-06 ダイキン工業株式会社 耐油剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994981A (en) * 1971-11-04 1976-11-30 Stauffer Chemical Company Derivatives of certain geranyl phenyl ethers
JPS58177953A (ja) 1982-04-13 1983-10-18 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法
JPH04331983A (ja) * 1991-05-08 1992-11-19 Hitachi Ltd 表示装置
US5298655A (en) 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
EP0670317B9 (en) 1993-09-22 2001-03-14 Kyowa Hakko Kogyo Co., Ltd. Epoxycyclohexenedione derivative
US5571687A (en) 1994-06-07 1996-11-05 Duke University Modulators of multidrug resistance transporters
JP3631298B2 (ja) 1995-07-31 2005-03-23 長谷川香料株式会社 置換グルコサミン誘導体および持続性香料組成物
FR2783517B1 (fr) * 1998-09-22 2001-02-09 Oreal Nouveaux derives de l'acide 10-hyroxy-2-decenoique et utilisation dans une composition destinee a favoriser la desquamation de la peau, et composition le comprenant
EP1361433A3 (en) * 2002-04-09 2005-02-23 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Method for estimating therapeutic efficacy of tumor necrosis factor (TNF)

Also Published As

Publication number Publication date
US7553820B2 (en) 2009-06-30
KR100946603B1 (ko) 2010-03-09
EP1471052B1 (en) 2011-08-10
TW200302227A (en) 2003-08-01
US20060142244A1 (en) 2006-06-29
US7579376B2 (en) 2009-08-25
CA2472335A1 (en) 2003-07-24
CA2706833A1 (en) 2003-07-24
EP2404894B1 (en) 2013-09-11
WO2003059866A1 (en) 2003-07-24
US7125852B2 (en) 2006-10-24
BRPI0215485B1 (pt) 2016-07-19
CA2706832C (en) 2012-07-10
US20080113939A1 (en) 2008-05-15
EP2399900B1 (en) 2013-08-07
BR0215485A (pt) 2004-12-28
CA2706826C (en) 2013-01-15
CA2706826A1 (en) 2003-07-24
CN1612857A (zh) 2005-05-04
CN1307148C (zh) 2007-03-28
KR20090035645A (ko) 2009-04-09
AU2002361126C1 (en) 2008-08-07
AU2002361126B2 (en) 2008-01-31
US20080119556A1 (en) 2008-05-22
EP1471052A1 (en) 2004-10-27
MXPA04006636A (es) 2004-10-04
EP2399900A1 (en) 2011-12-28
TWI230162B (en) 2005-04-01
US7507765B2 (en) 2009-03-24
CA2472335C (en) 2010-09-14
CA2706833C (en) 2013-01-15
ZA200404877B (en) 2005-07-27
EP2399899A1 (en) 2011-12-28
ATE519733T1 (de) 2011-08-15
EP2404894A1 (en) 2012-01-11
KR20090036150A (ko) 2009-04-13
AU2002361126A1 (en) 2003-07-30
KR100946602B1 (ko) 2010-03-09
KR20040075072A (ko) 2004-08-26
EP2399899B1 (en) 2013-08-07
CA2706832A1 (en) 2003-07-24
US20050119474A1 (en) 2005-06-02
KR20090036149A (ko) 2009-04-13
EP1471052A4 (en) 2007-05-02
KR100908595B1 (ko) 2009-07-22
KR100900179B1 (ko) 2009-06-02

Similar Documents

Publication Publication Date Title
BRPI0215485B8 (pt) compostos de geranila, agente antitumoral, composição farmacêutica, e, uso de um composto de geranila
DE3660010D1 (en) Peptide derivatives with a polycyclic nitrogen structure, process for their preparation and pharmaceutical compositions containing them
Hanada et al. Inhibitory Activities of E–64 Derivatives on Papain
ES2331832T3 (es) Nuevo derivado de acido lipoico y su uso.
IL149008A0 (en) Stabilized liquid polypeptide-containing pharmaceutical compositions
RU2011119643A (ru) Фармацевтические композиции с уменьшенным высвобождением фенольных опиоидов
EP2130548A3 (en) Growth Hormone Releasing Peptides
AU2003264412A1 (en) Melanin extinguisher
US5359128A (en) Malic acid derivatives and compositions for the treatment of psoriasis
EP1333022A3 (fr) Compositions comprenant des dérivés du cyclopentane, et utilisation pour favoriser la desquamation
EP1043322A4 (en) DERIVATIVES OF VITAMIN E
EP1392346A2 (en) Composition and method for enhancing elasticity of tissue
AU2001275018A1 (en) Composition and method for enhancing elasticity of tissue
GB2131690A (en) Analgesic agent containing bestatin derivatives
US20220000814A1 (en) Methods for treatment of prader-willi syndrome
US5145872A (en) Peptides with pharmaceutical activity
NZ512891A (en) S-oxide lipid lowering compounds
JPWO2000064926A1 (ja) メラノサイト刺激ホルモン阻害剤
JPS6354322A (ja) 副作用の軽減されたペネム型またはカルバペネム型抗生物質製剤
DE10111161A1 (de) Neue Siderophoranaloga als 4- oder 6-zähnige Eisenchelatoren auf der Basis von Aminosäuren oder Peptiden, Verfahren zu ihrer Herstellung und ihre Anwendung
EP0249434A3 (en) Peptide derivatives and processes for their preparation
CY1106169T1 (el) Συνθεση αποτελουμενη απο προπιονυλ l-καρνιτινη και γλυκινη για την προληψη και/ή θepαπεια των κυτοτοξικων αποτελεσματων που διεγειρονται απο τη χρηση ανοσοκατασταλτικων παραγοντων
AU2008200719A1 (en) Geranyl compounds
ATE276273T1 (de) Vip-analoge

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/07/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/12/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B15V Prolongation of time limit allowed
B22B Petition not considered [chapter 22.2 patent gazette]

Free format text: NAO CONHECIDA A PETICAO NO 870210083186, DE 09/09/2021, EM VIRTUDE DO DISPOSTO NO ART. 219 , INCISO II DA LPI

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 26/12/2022