BRPI0307837B8 - molécula de anticorpo anti-peptídeo beta-a-4, composições e seus usos - Google Patents

molécula de anticorpo anti-peptídeo beta-a-4, composições e seus usos

Info

Publication number
BRPI0307837B8
BRPI0307837B8 BRPI0307837A BR0307837A BRPI0307837B8 BR PI0307837 B8 BRPI0307837 B8 BR PI0307837B8 BR PI0307837 A BRPI0307837 A BR PI0307837A BR 0307837 A BR0307837 A BR 0307837A BR PI0307837 B8 BRPI0307837 B8 BR PI0307837B8
Authority
BR
Brazil
Prior art keywords
molecule
compositions
nucleic acid
antibody
beta
Prior art date
Application number
BRPI0307837A
Other languages
English (en)
Other versions
BR0307837A (pt
BRPI0307837B1 (pt
Inventor
Bohrmann Bernd
Nordstedt Christer
Rothe Christine
Löhning Corinna
Loetscher Hansruedi
Brockhaus Manfred
Bardroff Michael
Kretzschmar Titus
Huber Walter
Original Assignee
Hoffmann La Roche
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27741103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0307837(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Morphosys Ag filed Critical Hoffmann La Roche
Publication of BR0307837A publication Critical patent/BR0307837A/pt
Publication of BRPI0307837B1 publication Critical patent/BRPI0307837B1/pt
Publication of BRPI0307837B8 publication Critical patent/BRPI0307837B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)

Abstract

molécula de anticorpo, vetor, célula hospedeira, método para preparação da dita molécula,método composição, uso da referida molécula, kit, método para otimização da referida molécula, bem como método para preparação da dita composição. a presente invenção refere-se a moléculas de anticorpo capazes de especificamente reconhecer duas regiões do peptídeo ß-a4, em que a dita primeira região compreende a sequência de aminoácido aefrhdsgy conforme mostrado na seq id no:1 ou um seu fragmento e em que a segunda região compreende a sequência de aminoácido vhhoklvffaedvg conforme mostrado na seq id no:2 ou um seu fragmento. ainda, as moléculas de ácido nucléico codificando as moléculas de anticorpo da invenção e vetores e hospedeiros compreendendo as ditas moléculas de ácido nucléico são descritos. em adição, a presente invenção provê composições, de preferência composições farmacêuticas ou de diagnóstico, compreendendo os compostos da invenção, bem como usos específicos das moléculas de anticorpo, moléculas de acido nucléico, vetores ou hospedeiros da invenção.
BRPI0307837A 2002-02-20 2003-02-20 molécula de anticorpo anti-peptídeo beta-a-4, composições e seus usos BRPI0307837B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02003844 2002-02-20
EP02003844.4 2002-02-20
PCT/EP2003/001759 WO2003070760A2 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use

Publications (3)

Publication Number Publication Date
BR0307837A BR0307837A (pt) 2004-12-07
BRPI0307837B1 BRPI0307837B1 (pt) 2020-11-10
BRPI0307837B8 true BRPI0307837B8 (pt) 2021-05-25

Family

ID=27741103

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307837A BRPI0307837B8 (pt) 2002-02-20 2003-02-20 molécula de anticorpo anti-peptídeo beta-a-4, composições e seus usos

Country Status (27)

Country Link
US (4) US7794719B2 (pt)
EP (2) EP1481008A2 (pt)
JP (2) JP4383888B2 (pt)
KR (1) KR101038828B1 (pt)
CN (4) CN101781368B (pt)
AR (2) AR038568A1 (pt)
AU (1) AU2003218995B2 (pt)
BR (1) BRPI0307837B8 (pt)
CA (1) CA2477012C (pt)
CL (1) CL2004001122A1 (pt)
CO (1) CO5601037A2 (pt)
CY (1) CY1118037T1 (pt)
DK (1) DK2368907T3 (pt)
ES (1) ES2590684T3 (pt)
HR (1) HRP20040712B1 (pt)
HU (1) HUE030591T2 (pt)
IL (2) IL163563A0 (pt)
LT (1) LT2368907T (pt)
MX (1) MXPA04008077A (pt)
NO (2) NO336112B1 (pt)
NZ (1) NZ534522A (pt)
PL (1) PL216190B1 (pt)
PT (1) PT2368907T (pt)
RU (1) RU2341533C2 (pt)
SI (1) SI2368907T1 (pt)
WO (1) WO2003070760A2 (pt)
ZA (1) ZA200406604B (pt)

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